THE SIGNIFICANCE OF MUTATIONS IN THE INTERLEUKIN-1B GENE IN THE DEVELOPMENT OF ATONIC POSTPARTUM HEMORRHAGE
Keywords:
T-31C polymorphism, IL1B gene, genetic markers, autoamplification, atonic postpartum hemorrhageAbstract
In our study the association of T-31C polymorphism in the IL1B gene and risk of atonic postpartum hemorrhage in women of Uzbek nationality were identified. 101 women with postpartum atonic bleeding were studied. An association with the T-31C polymorphism in the IL1B gene was identified. Carriers of the heterozygous genotype T/C tend to develop atonic PPH, which has not statistical significance.
References
Bateman BT, Berman MF, Riley LE, Leffert LR. The epidemiology of postpartum hemorrhage in a large, nationwide sample of deliveries. Anesth Analg 2010;110:1368–73. doi: 10.1213/ ANE.0b013e3181d74898 [PubMed: 20237047].
Girard T, Mörtl M, Schlembach D. New approaches to obstetric hemorrhage: the postpartum hemorrhage consensus algorithm. Curr Opin Anaesthesiol 2014;27:267–74. doi: 10.1097/ ACO.0000000000000081
Bingham D, Melsop K, Main E. CMQCC Obstetric hemorrhage hospital level implementation guide. Stanford University; 2010
Bochner, B.S.; Luscinskas, F.W.; Gimbrone, M.A., Jr.; Newman, W.; Sterbinsky, S.A.; Derse-Anthony, C.P.; Klunk, D.; Schleimer, R.P. Adhesion of human basophils, eosinophils, and neutrophils to interleukin-1 activated endothelial cells: Contributions of endothelial adhesion molecules. J. Exp. Med. 2021, 173, 1553–1557.
Dinarello, C.A. Biologic basis for interleukin-1 in disease. Blood 2016, 87, 2095–2147.
Yang, Y.; Wu, W.; Wang, L.; Ding, Y. Lack of association between interleukin-1β receptor antagonist gene 86-bp VNTR polymorphism and ischemic stroke: A meta-analysis. Medicine 2018, 97, e11750.
Lynch, M.A. Neuroinflammatory changes negatively impact on LTP: A focus on IL-1beta. Brain Res. 2015, 1621, 197–204.
Goracy I, Kaczmarczyk M, Ciechanowicz A et al. Polymorphism of Interleukin 1B May Modulate the Risk of Ischemic Stroke in Polish Patients. Medicina 2019, 55, 558; doi:10.3390/medicina55090558.
Rakhimov M. Nodir, Shakhanova Sh. Shakhnoza Abdurakhmonov A. Jurabek, Talibova A. Nilufar, Sulimova G. Olga. The effectiveness of treatment of ascites due to recurrence of platinum-refractory ovarian cancer using metronomic chemotherapy. Journal of reproductive health and uro-nephrology research 2024 vol 5 issue 1, pp.37-41
Shakhanova Shakhnoza Shavkatovna, Rakhimov Nodir Makhammatkulovich , ., & Murodov Shakhzod Tokhirjon Ugli , . (2024). ASPECTS OF SARCOPENIA SYNDROME IN ONCOLOGICAL PRACTICE: DIAGNOSIS AND TREATMENT. The American Journal of Medical Sciences and Pharmaceutical Research, 6(02), 16–25. https://doi.org/10.37547/TAJMSPR/Volume06Issue02-03
Sh.Sh.Shakhanova, ., J.A. Abdurakhmonov, ., & N.M.Rakhimov, . (2023). TARGETED THERAPY IN THE PALLIATIVE TREATMENT OF PLATINUM-RESISTANT RECURRENT OVARIAN CANCER COMPLICATED BY ASCITES. The American Journal of Medical Sciences and Pharmaceutical Research, 5(08), 77–81.
Schmid M, Haslinger P, Stary S, Leipold H, Egarter C, Grimm C. Interleukin-1 beta gene polymorphisms and preterm birth. Eur J Obstet Gynecol Reprod Biol 2012; 165:33–36.
Kim JO, Lee WS, Lee BE, Jeon YJ, Kim YR, Jung SH, Chang SW, Kim NK. Interleukin-1beta -511T>C genetic variant contributes to recurrent pregnancy loss risk and peripheral natural killer cell proportion. Fertil Steril. 2014;102:206–212.e5.
Статья поступила в редакцию 27.05.2024; одобрена после рецензирования 22.06.2024; принята к публикации 29.06.2024.
The article was submitted 27.05.2024; approved after reviewing 22.06.2024; accepted for publication 26.06.2024.
Информация об авторах
Ашурова Умида Алишеровна- PhD, докторант. Ташкентская медицинская академия Ташкент, Узбекистан. email: umida.ashurova@gmail.com. https://orcid.org/0009-0004-3379-2822
