GENETIC ASPECTS AND DIAGNOSIS OF CONGENITAL MALFORMATIONS OF THE GENITALS

Authors

  • NEGMADJANOV Bakhodur Boltayevich
  • MAKHMUDOVA Sevara Erkinovna

Keywords:

congenital anomalies of genital development, bicornuate uterus, genetics, diagnosis, aplasia of uterus and vagina

Abstract

Infertility is often caused by congenital anomalies of sexual development and is associated with an unfavorable reproductive prognosis. In recent years, the development of assisted reproductive technologies has significantly improved the reproductive prognosis of infertile patients. Improvement of reproductive prognosis in congenital anomalies of sexual development largely depends on timely diagnosis of anomalies and rational management of patients

References

Dietrich J.E., Millar D.M., Quint E.H. Obstructive reproductive tract anomalies // J. Pediatr. Adolesc. Gynecol. 2014. Vol. 27, N 6. P. 396–402. DOI: https://doi.org/10.1016/j.jpag.2014.09.001 Epub 2014 Sep 11. PMID: 25438708.

Deans R., Berra M., Creighton S.M. Management of vaginal hypoplasia in disorders of sexual development: surgical and non-surgical options // Sex Dev. 2020. Vol. 4. P. 292-299.

Di Spiezio Sardo A., Florio P., Nazzaro G., Spinelli M., Paladini D., Di Carlo C. et al. Hysteroscopic outpatient metroplasty to expand dysmorphic uteri (HOME-DU technique): a pilot study // Reprod. Biomed. Online. 2015. Vol. Тридцать, N 2. P. 166– 174.

Fedele L., Frontino G., Restelli E., Ciappina N., et al. Creation of a neovagina by Davydov’s laparoscopic modified technique in patients with Rokitansky syndrome// Am. J. Obstet. Gynecol. 2020. Vol. 202, N 1. P. 33.e1–e6.

Fedele L., Motta F., Frontino G., Restelli E., et al. Double uterus with obstructed hemivagina and ipsilateral renal agenesis: pelvic anatomic variants in 87 cases // Hum. Reprod. 2013 Jun. Vol. 28, N 6. P. 1580–1583.

Heinonen P. Pregnancies in women with uterine malformation, treated obstruction of hemivagina and ipsilateral renal agenesis // Arch. Gynecol. Obstet. 2013. Vol. 287, N 5. P. 975–978

Keser A., Bozkurt N., Taner O.F. et al. Treatment of vaginal agenesis with modified Abbe-McIndou technique: long-term follow-up in 22 patients // Eur. J. Obstet. Gynecol. Reprod. Biol. 2015. Vol. 121. P. 110.

Toublanc J.E., Roger M., Chaussain J.L. Etiologies of late puberty. 2021. -Vol. 36. — P.136-140.

Vetter U., Fedarko N.S., Yong M.F. et al. Biglycan sythesis in fibroblasts of patients with Turner syndrome and other sex chromosome anomalies//1.: Basicand clinical approach to Turner syndrome. - Amsterdam: Elsevier Science Pub, 2023.-P. 143-146.

Warming L., Raun P., Nielsen T. Safety and aficacy of drospirenone in a continuous combination with 17b-estradiol for prevention of osteoporosis. -Climacteric. 2014. - №7. - P. 103-107.

Wattiez A. et. al. Laparoscopic operations for stress incontinence. Endoscopy for diagnosis and treatment of uterine pathology. Moscow. -2017. - P. 165.

Wilson J.D. The Role of Androgens in Male Gender Role Behavior // Endocr. Rev. 2019. - Vol.Двадцатый, №5.- P. 726-737.

Ziyadullaev , S., Elmamatov , O., Raximov , N., & Raufov , F. (2020). Cytogenetic and immunological alterations of recurrent bladder cancer. European Journal of Molecular & Clinical Medicine , 7 (2), 1877-1883.

Ziyadullaev SK et al. MARKER TNF α -308G/A IN PATIENTS WITH RELATIVE BLADDER CANCER //Oriental renaissance: Innovative, educational, natural and social sciences. – 2021. – T. 1. – No. 8. – pp. 926-93.

Ziyadullaev Sh., Rakhimov N., Elmamatov O. Immunocytogenetic aspects of bladder cancer // Journal of the Doctor's Bulletin. – 2020. – T. 1. – No. 4.

Published

2025-02-11