OIV INFEKTSIYASIDA IMMUNOLOGIK FAOLLASHISHNING MOLEKULAR MEXANIZMLARI
##article.subject##:
OIV, OITS, CD4+, replikatsiya, interferonlar, TLR, CLR, RLR, interferon bilan rag‘batlantirilgan genlar ISG##article.abstract##
OIV infektsiyasiga javob reaktsiyalarining hosil bo’lishida tug'ma immun tizimining roli, patternlarni tanishda ishtirok etadigan retseptorlar, TLR, CLR va RLR roli ma'lumdir. Ushbu retseptorlarning faollashishi I turdagi interferonlarni sintezlanishiga olib keladi, bu infektsiyaning dastlabki bosqichlarida virusli replikatsiyani cheklashga yordam beradi. Shu bilan birga, OIVning immunitet tizimi bilan surunkali o'zaro ta'siri bu yo'llarning uzoq vaqt faollashishiga, yallig'lanish va immun gomeostazining buzilishiga olib kelishi mumkin. Interferon stimulyashgan genlar ISG mihim bo’lib, ular organizmni himoya qilishda asosiy rol o'ynaydi, ammo OIV evolyutsiyasi bu mexanizmlarni bostirish uchun mexanizmlarni ishlab chiqgan, uning organizmda uzoq vaqt saqlanib qolishiga imkon beradi. Ushbu maqolada immun himoyaning turli molekulalari va mexanizmlari, jumladan, interferonlar va ularning retseptorlari, shuningdek, virusga qarshi faollikda ishtirok etadigan va terapevtik yondashuvlar uchun potentsial bo’lgan APOBEC3G va ISG15 genlarining roli ko'rib chiqiladi.
Библиографические ссылки
Anderson, B. D., & Harris, R. S. (2015). Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-beta/RUNX axis. Science Advances, 1, e1500296.
Bagheri-Hosseinabadi, Z., Zarandi, E. R., Mirabzadeh, M., Amiri, A., & Abbasifard, M. (2022). mRNA expression of toll-like receptors 3, 7, 8, and 9 in the nasopharyngeal epithelial cells of coronavirus disease 2019 patients. BMC Infectious Diseases, 22, 448.
Barnea, E., Melamed Kadosh, D., Haimovich, Y., et al. (2017). The human leukocyte antigen (HLA)-B27 peptidome in vivo, in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of Erap1 deletion. Molecular & Cellular Proteomics, 16(4), 642–662. https://doi.org/10.1074/mcp.M116.066241
Bermejo-Jambrina, M., Eder, J., Helgers, L. C., et al. (2018). C-Type Lectin Receptors in Antiviral Immunity and Viral Escape. Frontiers in Immunology, 9, 590. https://doi.org/10.3389/fimmu.2018.00590
Binning, J. M., et al. (2018). Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors. PLOS Pathogens, 14, e1006830.
Brennan, C. A., Ibarrondo, F. J., Sugar, C. A., et al. (2012). Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression. Journal of Virology, 86(19), 10505-10516. https://doi.org/10.1128/JVI.00102-12
Burdick, R. C., et al. (2020). HIV-1 uncoats in the nucleus near sites of integration. Proceedings of the National Academy of Sciences of the United States of America, 117, 5486–5493.
Caputo, V., Libera, M., Sisti, S., et al. (2023). The initial interplay between HIV and mucosal innate immunity. Frontiers in Immunology, 14, 1104423.
Carrington, M., & Alter, G. (2012). Innate immune control of HIV. Cold Spring Harbor Perspectives in Medicine, 2(7), a007070. https://doi.org/10.1101/cshperspect.a007070
Christensen, D. E., Ganser-Pornillos, B. K., Johnson, J. S., et al. (2020). Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro. Science, 370, eabc8420.
Diao, B., Du, J., Liu, Y., Luo, F., & Hou, W. (2014). The association of HLA-DRB1 alleles and drug use with HIV infection in a Chinese Han cohort. The Brazilian Journal of Infectious Diseases, 18(1), 82–87. https://doi.org/10.1016/j.bjid.2013.04.007
Geijtenbeek, T., & Gringhuis, S. (2016). C-type lectin receptors in the control of T helper cell differentiation. Nature Reviews Immunology, 16(7), 433–448.
German Advisory Committee Blood (Arbeitskreis Blut), Subgroup ‘Assessment of Pathogens Transmissible by Blood’. (2016). Human Immunodeficiency Virus (HIV). Transfusion Medicine and Hemotherapy, 43(3), 203–222.
Horsburgh B. A., Lee, E., Hiener B., Eden, J. S., Schlub T. E., von Stockenstrom S., Odevall L., Milush J. M., Liegler T., Sinclair E., Hoh R., Boritz E. A., Douek D. C., Fromentin R., Chomont N., Deeks S. G., Hecht F. M., & Palmer S. (2020). High levels of genetically intact HIV in HLA-DR+ memory T cells indicates their value for reservoir studies. AIDS, 34(5), 659–668. https://doi.org/10.1097/QAD.0000000000002465
Li, S. S., Gilbert P. B., Tomaras G. D., Kijak G., Ferrari G., Thomas R., Pyo C. W., Zolla-Pazner S., Montefiori D., Liao H. X., Nabel G., Pinter A., Evans D. T., Gottardo R., Dai J. Y., Janes H., Morris D., Fong Y., Edlefsen P. T., Li F., Frahm N., Alpert M. D., Prentice H., Rerks-Ngarm S., Pitisuttithum P., Kaewkungwal J., Nitayaphan S., Robb M. L., O'Connell R. J., Haynes B. F., Michael N. L., Kim J. H., McElrath M. J., & Geraghty D. E. (2014). FCGR2C polymorphisms associate with HIV-1 vaccine protection in RV144 trial. Journal of Clinical Investigation, 124(9), 3879–3890. https://doi.org/10.1172/JCI75539
Li Y. L., Langley C. A., Azumaya C. M., et al. (2023). The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 728–733. https://doi.org/10.1038/s41586-023-05779-1
Liu, J., Ghneim, K., Sok, D., Bosche, W. J., Li, Y., Chipriano, E., Berkemeier, B., Oswald, K., Borducchi, E., Cabral, C., Peter, L., Brinkman, A., Shetty, M., Jimenez, J., Mondesir, J., Lee, B., Giglio, P., Chandrashekar, A., Abbink, P., Colantonio, A., Gittens, C., Baker, C., Wagner, W., Lewis, M. G., Li, W., Sekaly, R. P., Lifson, J. D., Burton, D. R., Barouch, D. H. (2016). Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus. Science, 353(6303), 1045–1049.
Manches, O., Frleta, D., & Bhardwaj, N. (2014). Dendritic cells in progression and pathology of HIV infection. Trends in Immunology, 35(3), 114–122. https://doi.org/10.1016/j.it.2013.10.003
Murugaiah, V., Yasmin, H., Pandit, H., Ganguly, K., Subedi, R., Al-Mozaini, M., Madan, T., & Kishore, U. (2021). Innate immune response against HIV-1. Advances in Experimental Medicine and Biology, 1313, 23–58. https://doi.org/10.1007/978-3-030-67452-6_3
Nasr, N., Alshehri, A. A., Wright, T. K., Shahid, M., Heiner, B. M., Harman, A. N., Botting, R. A., Helbig, K. J., Beard, M. R., Suzuki, K., Kelleher, A. D., Hertzog, P., & Cunningham, A. L. (2017). Mechanism of interferon-stimulated gene induction in HIV-1-infected macrophages. Journal of Virology, 91(20), e00744-17. https://doi.org/10.1128/JVI.00744-17
Nyamweya, S., Hegedus, A., Jaye, A., Rowland-Jones, S., Flanagan, K. L., & Macallan, D. C. (2013). Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis. Reviews in Medical Virology, 23(4), 221–240. https://doi.org/10.1002/rmv.1739
Okoye, A. A., & Picker, L. J. (2013). CD4(+) T-cell depletion in HIV infection: Mechanisms of immunological failure. Immunological Reviews, 254(1), 54–64. https://doi.org/10.1111/imr.12047
Parham, P. (2014). The immune system (4th ed.). Garland Science.
Perng, Y. C., & Lenschow, D. J. (2018). ISG15 in antiviral immunity and beyond. Nature Reviews Microbiology, 16(7), 423–439. https://doi.org/10.1038/s41579-018-0020-5
Pollpeter, D., et al. (2018). Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G. Nature Microbiology, 3, 220–233. https://doi.org/10.1038/s41564-018-0032-0
Raftery, N., & Stevenson, N. J. (2017). Advances in anti-viral immune defence: Revealing the importance of the IFN JAK/STAT pathway. Cellular and Molecular Life Sciences, 74(14), 2525–2535. https://doi.org/10.1007/s00018-017-2520-2
Roff, S. R., Noon-Song, E. N., & Yamamoto, J. K. (2014). The significance of interferon-γ in HIV-1 pathogenesis, therapy, and prophylaxis. Frontiers in Immunology, 4, 498. https://doi.org/10.3389/fimmu.2013.00498
Schoofs, T., Klein, F., Braunschweig, M., Kreider, E. F., Feldmann, A., Nogueira, L., Oliveira, T., Lorenzi, J. C., Parrish, E. H., Learn, G. H., West, A. P., Bjorkman, P. J., Schlesinger, S. J., Seaman, M. S., Czartoski, J., McElrath, M. J., Pfeifer, N., Hahn, B. H., Caskey, M., & Nussenzweig, M. C. (2016). HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1. Science, 352(6288), 997–1001. https://doi.org/10.1126/science.aaf0972
Sok, D., Laserson, U., Laserson, J., Liu, Y., Vigneault, F., Julien, J. P., Briney, B., Ramos, A., Saye, K. F., Le, K., Mahan, A., Wang, S., Kardar, M., Yaari, G., Walker, L. M., Simen, B. B., St John, E. P., Chan-Hui, P. Y., Swiderek, K., Kleinstein, S. H., Alter, G., Seaman, M. S., Chakraborty, A. K., Koller, D., Wilson, I. A., Church, G. M., Burton, D. R., Poignard, P. (2013). The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. PLoS Pathogens, 9(11), e1003754. https://doi.org/10.1371/journal.ppat.1003754
Telesnitsky, A., & Wolin, S. L. (2016). The host RNAs in retroviral particles. Viruses, 8(8), 235. https://doi.org/10.3390/v8080235
Рахимов Н. М. и др. ЭФФЕКТИВНОСТЬ ЛЕЧЕНИЯ АСЦИТА ОБУСЛОВЛЕННЫЙ РЕЦИДИВОМ ПЛАТИНОРЕФРАКТЕРНОГО РАКА ЯИЧНИКА С ИСПОЛЬЗОВАНИЕМ МЕТРОНОМНОЙ ХИМИОТЕРАПИИ //ЖУРНАЛ РЕПРОДУКТИВНОГО ЗДОРОВЬЯ И УРО-НЕФРОЛОГИЧЕСКИХ ИССЛЕДОВАНИЙ. – 2024. – Т. 5. – №. 1.
Abdurakhmonov Jurabek , Rahimov Nodir , Shakhanova Shakhnoza . Modern view on ascite in ovarian cancer. Journal of Biomedicine and Practice . 2022, vol . 7, issue 4, pp . 130-139
Alimjanovich JR, Agababyan LR, Kamalov AI Prevention and Treatment of Postpartum Hemorrhage //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2021. – T. 2. – No. 4. – S. 204-209.
Rizaev Jasur , Rakhimov Nodir , Kodyrov Khamidullo , Shakhanova Shakhnoza . Study of prostate cancer death by regions of the republic of Uzbekistan.Journal of Biomedicine and Practice. 2022, vol . 7, issue 5, pp.202-210
van Montfoort, N., van der Aa, E., & Woltman, A. M. (2014). Understanding MHC class I presentation of viral antigens by human dendritic cells as a basis for rational design of therapeutic vaccines. Frontiers in Immunology, 5, 182. https://doi.org/10.3389/fimmu.2014.00182
Wibmer, C. K., Moore, P. L., & Morris, L. (2015). HIV broadly neutralizing antibody targets. Current Opinion in HIV and AIDS, 10(3), 135-143. https://doi.org/10.1097/COH.0000000000000153
Wieczorek, M., Abualrous, E. T., Sticht, J., Álvaro-Benito, M., Stolzenberg, S., Noé, F., & Freund, C. (2017). Major histocompatibility complex (MHC) class I and MHC class II proteins: Conformational plasticity in antigen presentation. Frontiers in Immunology, 8, 292. https://doi.org/10.3389/fimmu.2017.00292
World Health Organization. (n.d.). HIV and AIDS. https://www.who.int/news-room/fact-sheets/detail/hiv-aids
Xu, X., Wan, H., & Nie, L. et al. (2018). RIG-I: A multifunctional protein beyond a pattern recognition receptor. Protein & Cell, 9(3), 246-253. https://doi.org/10.1007/s13238-017-0431-5
УДК: 615.89
