АЁЛЛАРДА ҚИН МИКРОФЛОРАСИДАГИ ЎЗГАРИШЛАРНИНГ ХУСУСИЯТЛАРИ
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Микрофлора, Колонизация микроорганизма, нормоциноз, биоциноз, менапауза, лактобаццилы, патоген микроорганизм, пептострептококки, бактероиды, стафилококки, стрептококки, гарднереллы, кандида##article.abstract##
Бизнинг организмимизда кўплаб микроорганизмлар яшайди. Улар тери, оғиз ва бурун шиллиқ қаватларида, ичакларда, аёлларда эса қинда ҳам яшайдилар.
Қин девори кўп қаватли мугузланмайдиган ясси эпителий билан қопланган бўлиб ўзида безлар тутмайди.
Ҳимоя функциясини бажарадиган қин эпителияси патоген моддалар (бактериялар, вируслар, замбуруғлар) таъсирига чидамлилигини таъминлайди. Қин эпителия резистентлигиниг муҳим кўрсаткичи асосан юза ҳужайраларида мавжуд бўлган гликоген миқдори ҳисобланади. Ушбу ҳужайралар доимо алмашиниб, парчаланиб кетганлиги сабабли, гликоген нормал микрофлора учун озиқлантирувчи субстрат билан таъминланади. Аёлларда қин эпителия ҳужайраларида гликоген миқдори ҳаёт давомида алмашиниб, ҳайз даврининг босқичига қараб фарқ қилади. Гликогеннинг максимал тўпланиши овулятция вақтида содир бўлади. Қин микрофлоралар қатъий индивидуалдир ва ҳатто норма ҳолатида ҳам ҳайз даврининг турли босқичларида ўзгариши мумкин. Бундан ташқари, меъёр тушунчаси турли ёш, этник гуруҳлар ва ҳатто географик ҳудудлар учун фарқ қилиши мумкин. Шу муносабат билан қиннинг нормал микробиосенози (нормотсеноз) вариантлари мавжуд
Библиографические ссылки
Analysis of the course of pregnancy in women infected with Ur.urealyticum, depending on the degree of colonization of the genital tract T.A. Melnikova, M.M. Padrul, E.S. Horowitz, G.I. Rabotnikova Perm Medical Journal. - 2017.- Vol. 34, No.2. - pp. 26-30.
Karapetyan, T.E. Aerobic vaginitis and pregnancy T. E.Karapetyan, V. V.Muravyeva, A. S.Ankirskaya Obstetrics and gynecology. - 2013.- No. 4.- pp. 25-28.
Kostin, I.N. Significance and results of the international research project "Human Microbiome" I.N.Kostin,L.Yu.Kuvankina, H.Yu. Simonovskaya StatusPraesens. – 2013. – №5(16). – P.9-15
Kuzmin, V.N.The place and role of mycoplasma infection in the structure of inflammatory diseases of the pelvic organs V.N.
Kuzmin Gynecology. - 2015.- No. 2.- pp. 21-26 Laboratory diagnostics of bacterial vaginosis:methodological recommendations A.M. Savicheva, M.A. Bashmakova, T.V. Krasnoselskikh [et al.]. - St. Petersburg: Publishing House N-L, 2011.-28 p.
Tavo, V. Prevalence of Mycoplasma hominis and Ureaplasma urealyticum among women of reproductive age in Albania V. Tavo Med. Arch. - 2013. - Vol. 67, No. 1. - pp. 25-26. doi:10.5455/medarch.2013.67.25-26
Temporal and spatial changes in the human microbiota during pregnancy / D.B. DiGiulio, B.J. Callahan, P.J. Mcmurdy [et al.] PNAS.-2015. - vol. 112, No. 35. - pp.11060-11065. doi:10.1073 pnas.150287511
The composition and stability of the vaginal microbiota of normal pregnant women differ from the composition and stability of non-pregnant women R. Romero, S.S. Hassan, P. Hajer [et al.] Microbiome. - 2014. - Vol.2, No. 1. - p.4. doi:10.1186/2049-2618-2
Interaction between the microbiota of the vagina, the length of the cervix and treatment with vaginal progesterone to reduce the risk of premature birth L.M. Kindinger, P.R.Bennett, Y.S. Lee [et al.] Microbiome. - 2017. - Vol. 5, 1. - p.6.doi:10.1186 40168-016-0223
The role of infection in miscarriage S. Giakoumelou, N. Wheelhouse, K. Cuschieri [et al.] Hum. Reprod. Update. – 2016. – Vol. 22, № 1. – P.116-133. doi:10.1093/humupd/dmv041
The vaginal microbiome and preterm birth J.M. Fettweis, M.G.Serrano, J.P. Brooks [et al.] Nat. Med. - 2019. - Vol. 25, No. 6. - P.1012-1021. doi:10.1038/s41591-019-0450
Aldunate, M., Srbinowski, D., Herps, A.S., Latham, K.F., Ramsland, P.A., Gugasyan, R. and Tachejian, G... "Antimicrobial and immunomodulatory effects of lactic acid and short-chain fatty acids produced by the vaginal microbiota are associated with eubiosis and bacterial vaginosis" Frontiers of Physiology 6 issue, (2015 d). p.164.
Balkus J. E. i , , Richardson B.A., Rabe L.K., Taha T.E., Mgodi N., Casaro M.P.. "Bacterial vaginosis and the risk of infection with Trichomonas vaginalis in HIV-1-negative women". Sexually transmitted diseases. Vol. 41. No. 2. (2014). p. 123.
Bjartling S., Osser S., Persson K. "The relationship between Mycoplasma genitalium and pelvic inflammatory diseases after termination of pregnancy." International Journal of Obstetrics and Gynecology. Vol. 117. No. 3. (2010). pp. 361-364.
Borgdorf H. and Armstrong S. D., Xia D., Ndayisaba G. F. "Dysbiosis of the cervicovaginal microbiome is associated with proteome changes associated with changes in the cervicovaginal mucosal barrier". Immunology of the mucous membrane. Vol. 9. No. 3. (2016). pp. 621-633.
Bradford L.L., Ravel J. "Vaginal mycobioma: a modern view of fungi in women's health and diseases" Virulence. Vol. 8. No. 3. (2017). pp. 342-351.
Brotman R.M. "Bacterial vaginosis assessed by Gram staining and reduced colonization resistance to accidental gonococcal, chlamydial and trichomonas genital infections". Journal of Infectious Diseases. Vol. 202. No. 12. (2010). pp. 1907-1915.
Bradshaw S.S. Morton A.N., Hawking J., Garland S.M., Morris M.B., Moss L.M. "High recurrence rate of bacterial vaginosis within 12 months after oral metronidazole therapy and factors associated with relapses." Journal of Infectious Diseases. -Vol. 193. No. 11. (2006). pp. 1478-1486.
Brotman, R. M., Shardell, M. D., Gajer, P., Fadrosh, D., Chang, K., Silver, M., & Gravitt, P. E. "Association between vaginal microbiota, menopause status and signs of vulvovaginal atrophy".Menopause (New York, New York). Vol. 21. No. 5. (2014). p. 450.
Karlsson I., Breding K. and Larsson, P.G. "Complications associated with artificial abortion: a combined retrospective and longitudinal follow-up study." Women's Health BMC. 18 (1), (2018). pp. 1-9.
Kazanav, K., L.E. Manhart and K. Beber. "Mycoplasma genitalium, a new sexually transmitted pathogen." Médecine et maladies Infectieuses 42.9. (2012) pp. 381-392.
Chen, K., Song, X., Wei, W., Zhong, H., Dai, J., Lan, Z. and Jia, H. "The microbiota continuum along the female genital tract and its relation to uterine diseases". Connections of nature. (2017). 8 (1) pp. 1-11.
Han, Yiwen, Zhaoxia Liu and Tingtao Chen. "The role of vaginal microbiota dysbiosis in gynecological diseases and possible interventions". Boundaries of microbiology. 12.(2021): Page 1538.
Chi, Yugan. "Transdermal estrogen gel and oral combination therapy with aspirin improve fertility prognosis by increasing endometrial susceptibility with moderate and severe intrauterine adhesion." Reports on Molecular Medicine 17.5 (2018): pp. 6337-6344.
Ризаев Ж.А., Назаров О.Ж., Гайбуллаева Ю.Х., Юнусханова К.Ш. РЕВМАТОИД АРТРИТ ВА ОСТЕОАРТРИТ КАСАЛЛИКЛАРИДА ОҒИЗ БЎШЛИҒИНИНГ МИКРОБИОМИ// Журнал биомедицины и практики, 2020, №6(5) 252-257
