FEATURES OF PATHOMORPHOLOGY AND IMMUNOHISTOCHEMISTRY IN RECURRENT MARRIAGE IN THE FIRST TRIMESTER OF PREGNANCY
Keywords:
recurrent miscarriage in the first trimester, immunohistochemistry, pathomorphology, receptors, endometriumAbstract
The problem of miscarriage continues to occupy one of the first places among the most important tasks of obstetrics and gynecology and is of great medical and social importance. Immunohistochemical and ultrastructural features of the endometrium during miscarriage are important for diagnosis in gynecological practice. Data on the expression of steroid receptors and proteins regulating the cell cycle are important diagnostic signs of miscarriage. Immunohistochemistry makes it possible to more accurately diagnose and monitor the effectiveness of hormonal treatment, provides an individual approach to the patient and, therefore, allows optimizing hormonal therapy regimens. The established morphological and immunohistochemical features of chronic endometritis emphasize the importance and need for a comprehensive study of scrapings and biopsies in the algorithm for examining patients with infertility and miscarriage. Thus, with habitual miscarriage, the index CD34, Ki62 expression of proteins involved in the formation of intercellular channels that control proliferation and differentiation of fibroblast-like cells of the endometrial stroma into predecidual ones. Structural and functional disorders in recurrent miscarriage result in endometrial insufficiency, which contributes to early termination of pregnancy.
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Статья поступила в редакцию 05.11.2023; одобрена после рецензирования 22.12.2023; принята к публикации 25.12.2023.
The article was submitted 05.11.2023; approved after reviewing 22.12.2023; accepted for publication 25.12.2023.
Информация об авторах:
Матризаева Гулнара Джуманиязовна- к.м.н., доцент, заведующий кафедрой Акушерства и гинекологии Ургенчского филиала Ташкентской медицинской академии, Ургенч, Узбекистан. Е-mail: gmatrizayeva@gmail.com; https://orcid.org/0009-0001-2796-8041
Ихтиярова Гулчехра Акмаловна- д.м.н., профессор, заведующий кафедрой Акушерства и гинекологии Бухарского Государственного медицинского института, Бухара, Узбекистан E-mail: ixtiyarova7272@mail.ru; https://orcid.org/0000-0002-2398-3711
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Матризаева Г.Д. - сбор и анализ источников литературы, написание текста;
Ихтиярова Г.А. - идеологическая концепция работы, написание текста; редактирование статьи.
Information about the authors:
Matrizaeva G. D. - Candidate of Medical Sciences, Associate Professor, Head of the Department of Obstetrics and Gynecology, Urgench Branch of the Tashkent Medical Academy, Urgench, Uzbekistan. E-mail: gmatrizayeva@gmail.com; https://orcid.org/0009-0001-2796-8041
Ikhtiyarova G. A. - Doctor of Medical Sciences, Professor, Head of the Department of Obstetrics and Gynecology, Bukhara State Medical Institute, Bukhara, Uzbekistan. E-mail: ixtiyarova7272@mail.ru; https://orcid.org/0000-0002-2398-3711
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Matrizayeva G.D.— collection and analysis of literature sources, writing the text;
Ixtiyarova G.A. — ideological concept of the work, writing the text; editing the article.
