DRUG THERAPY FOR ECHINOCOCCOSIS
Keywords:
chemotherapy for echinococcosis, albendazole, pulmonary echinococcosis, liver echinococcosisAbstract
Purpose of the study. To improve the results of drug therapy for echinococcosis.
Material and methods. In order to prevent relapse, 81 patients (26 with pulmonary echinococcosis, 45 with liver echinococcosis and 8 patients with combined pulmonary and liver echinococcosis received 3 courses of therapy) operated on for echinococcosis were given chemotherapy with mebendazole. 197 patients (69 with pulmonary echinococcosis, 107 with liver echinococcosis and 21 patients with combined pulmonary and liver echinococcosis) received chemotherapy with albendazole at a dose of 12 mg/kg per day for 30 days (3 courses). Albendazole was used for therapeutic purposes in 38 patients.
Results. All patients with echinococcosis received chemotherapy in the postoperative period. 79 patients took mebendazole in an amount of 40 ml/kg body weight for 30–35 days. 197 patients took albendazole at a dose of 12 ml/kg body weight for 30 days.
The anthelmintic effectiveness of the drugs mebendazole and albendazole was assessed on the basis of dynamic ultrasonography and x-ray control.
To evaluate the pharmacotherapy carried out, we used the parameters proposed by WHO experts (good and excellent results; satisfactory results; unsatisfactory results).
The effectiveness of treatment with albendazole for hydatid echinococcosis of the liver and lungs ranged from 58.37% to 82.23%, relapses were noted on average in 17.77% of patients.
Conclusions. Today, with traditional and minimally invasive interventions, subsequent preventive chemotherapy with albendazole is urgently needed.
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