JIGARNING ALKOGOLSIZ YOG'LI KASALLIGINI ZAMONAVIY DAVOLASHNING DOLZARB MASALALARI
##article.subject##:
jigar steatozi, AYJK, ASG, insulinga rezistentlik, diabetga qarshi dorilar, NGKT2 ingibitori.##article.abstract##
Jigarning alkogolsiz yog'li kasalligi (AYJK) metabolik sindrom (MS) omillaridan biri sifatida hozirgi vaqtda butun dunyoda eng keng tarqalgan jigar kasalligi hisoblanadi. Hozirgi vaqtda ushbu holat uchun maxsus dori terapiyasi ishlab chiqilmagan, uni davolash asosiy xavf omillarini davolashga asoslangan. Jigar parenximasida triglitseridlarning dastlabki to'planishi, yallig'lanish jarayonlari, mitoxondriyal disfunktsiya, lipotoksiklik, glyukoza toksikligi va oksidlovchi stress mavjud bo'lganda, alkogolsiz steatohepatit rivojlanishi mumkin. Asosiy maqsad bu evolyutsiyaga hissa qo'shadigan omillarni aniqlashdir, chunki davolanmagan AYJK fibrozdan sirozga o'tishi va oxir oqibatda gepatotsellyulyar karsinoma bilan yakunlanishi mumkin. Bir necha dori guruhlari AYJK uchun maxsus terapiya sifatida foydalanish uchun klinik sinovlardan o'tdi; ularning ko'pchiligi AYJK rivojlanishining asosiy xavf omillaridan biri bo'lgan 2-tip qandli diabet (QD2) ni davolashda qo”llaniladigan dorilar. Ulardan eng ko'p o'rganilganlari orasida PPAR-g agonistlari, tiazolidinedionlar (pioglitazon), glyukagonga o'xshash peptid-1 retseptorlari agonistlari (GLP-1aR) va dipeptidil peptidaz-4 ingibitorlari (DPP-4i) mavjud. Aslida, eng istiqbolli toifa - natriy-glyukoza kotransporter 2 inhibitorla258ri (NGKT2i). Biz NGKT2 ingibitorlaridan foydalanishga alohida e'tibor berib, AYJKni davolashning asosiy patogenetik mexanizmlari va zamonaviy usullarini ko'rib chiqamiz.
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