MORPHOLOGICAL CHANGES OF THE KIDNEYS OF RATS IN DIABETES INDUCED BY STREPTOZOTOCIN
Keywords:
morphology, morometry, kidney, ball, hyperglycemic nephropathies, atrophy, sclerosis, diabetes mellitus with streptothiazineAbstract
Type 1 diabetes mellitus (DM), more often type 2, is found in children. Although advanced hyperglycemic nephropathies (GN), such as loss of nephron filtration rate (NFT), do not occur until adulthood, renal biopsies show structural GN within 1.5–5 years after initiation of type 1 QD. shows changes. The earliest clinical sign of GN, such as increased urinary albumin excretion, usually appears in childhood and adolescence and is an important opportunity for early GN detection and treatment. Research in type 1 diabetes has shown that GN is characteristic of a subset of people with diabetes who are at high risk of premature death, which increases the focus on detection, prevention, and treatment of GN. Preliminary studies suggest that youth-onset type 2 diabetes is associated with a higher prevalence of risk factors. Research will help to better understand the risk factors, underlying mechanisms, and treatment options for GN in youth-onset type 2 diabetes.
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Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Tilyabov Ikram - Basic doctoral student Tashkent Medical Academy, ORCID 0009-0005-1365-9474, tilyabovi@gmail.com— ideological concept of the work, writing the text; editing the article;
Usmanov Ravshan Doctor of Medical science, professorTashkent Medical Academy ORCID 0000-0002-2459-9084 r.usmanov.54@mail.ru— collection and analysis of literature sources, writing the text.
Avtorlar to’g’risida ma’lumot:
Tilyabov Ikrom Tayanch doktorant Toshkent Tibbiyot Akademiyasi
tilyabovi@gmail.com ORCID 0009-0005-1365-9474 – maqolani matnini yozish; maqolani tahrirlash;
Usmanov Ravshan tibbiyot fanlari doktori, professor, Toshkent Tibbiyot Akademiyasi r.usmanov.54@mail.ru,ORCID: 0000-0002-2459-9084 adabiyot manbalarini to‘plash va tahlil qilish, matn yozish.
