ASSESSMENT OF THE SAFETY OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY IN PATIENTS WITH HIV INFECTION
Keywords:
human immunodeficiency virus, highly active antiretroviral therapy, viral load, nucleotide and non-nucleoside reverse transcriptase inhibitorAbstract
In this study, we investigated the safety of highly active antiretroviral therapy in HIV-infected patients. It is shown that as a result of the ineffectiveness and / or as a result of side effects of this therapy in 10.6% cases discontinued therapy performed or replacement regimens. One side effects of antiretroviral drugs - anemia occurs in 20.0% of HIV-infected patients and is often encountered when using regimens, containing azidotividin (AZT). In 8.5% of cases, the procedure has been changed due to the development of diarrheal syndrome. In addition, as the side effects of antiretroviral drugs developed lipodystrophy, peripheral neuropathy, and an increase of alanineaminotransferase activity.
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Статья поступила в редакцию 03.03.2024; одобрена после рецензирования 20.04.2024; принята к публикации 26.04.2024.
The article was submitted 03.03.2024; approved after reviewing 20.04.2024; accepted for publication 26.04.2024.
Информация об авторах:
Ачилова Матлюба Мирхамзаевна ассистент кафедры инфекционных болезней. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: achilovamatlyuba.88@mail.ru; https://orcid.org/0000-0002-5255-684X
Шодиева Дилафруз Абдужалоловна ассистент кафедры инфекционных болезней. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail:
dilafruzshodieva1985@gmail.com; https://orcid.org/0000-0003-2646-5036
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Ачилова М.М.— идеологическая концепция работы, написание текста;
Шодиева Д.А. — сбор и анализ источников литературы, написание текста.
Information about the authors:
Achilova Matlyuba Mirkhamzaevna assistant of the department of infectious diseases. Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: achilovamatlyuba.88@mail.ru; https://orcid.org/0000-0002-5255-684X
Shodieva Dilafruz Abdujalolovna assistant of the department of infectious diseases. Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: dilafruzshodieva1985@gmail.com; https://orcid.org/0000-0003-2646-5036
Sources of funding: The work did not have special funding.
Conflict of interest: The authors declare that there are no obvious or potential conflicts of interest related to the publication of this article.
Contribution of the authors:
Achilova M.M. - ideological concept of the work, writing the text;
Shodieva D.A. — collection and analysis of literature sources, writing text.
