«ДИАБЕТИЧЕСКАЯ НЕФРОПАТИЯ: ПРОБЛЕМЫ ПАТОГЕНЕЗА ЗАБОЛЕВАНИЯ. ОБЗОР ЛИТЕРАТУРЫ»
Ключевые слова:
сахарный диабет 2 типа, хроническая болезнь почек, биохимические показателиАннотация
Цель исследования – выполнить обзор литературы по вопросам патогенеза дитабетической нефропатии.
Материал и методы исследования. С целью анализа литературы был выполнен поиск, по ключевым словам, в Pubmed, Google Scholar, Scopus и др. сайты за последние 5-10 лет.
Результаты исследования. Патогенез ДН очень сложен и до сих пор до конца не изучен, что приводит к плохим терапевтическим результатам. Было показано, что стандартная терапия со строгим контролем уровня сахара в крови и артериального давления не способна остановить прогрессирование ДН до ТХПН и смертность, связанную с ДН. Улучшение понимания и изучение патогенетических механизмов ДН важно для разработки новых стратегий лечения ДН. Существует множество путей и медиаторов, участвующих в развитии и прогрессировании ДН , включая окислительный стресс, ангиотензин II (Ang-II) и воспалительные процессы, которые, как недавно считается, играют важную роль.
Выводы. Обзор литературы показал, что существует острая необходимость улучшить понимание механизма ДН, а затем разработать новые и эффективные терапевтические подходы для замедления развития ДН
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