MORPHOMETRIC CHARACTERIZATION OF THE PALATINE TONSIL IN CLINICALLY HEALTHY CHILDREN OF THE SECOND PERIOD OF CHILDHOOD (8–12 YEARS)
Keywords:
palatine tonsil, morphometry, histology, second period of childhood, lymphoid follicles, germinal centers, lymphoepithelial organ, Waldeyer's ring, mucosal immunityAbstract
The aim of the study was to determine the morphometric parameters of the palatine tonsil in clinically healthy children of the second period of childhood (boys aged 8–12, girls aged 8–11). In parallel, the work sought to assess whether sex-related differences exist in the indices of the lymphoepithelial apparatus at the final stage of its functional maturation. The palatine tonsils of 23 children were examined — 13 boys and 10 girls. None of the participants showed signs of inflammatory pathology. The sections were stained with hematoxylin and eosin. Analysis of the data showed that by the age of 8–12 years the palatine tonsil is already close to its final structural maturity. The crypts grow deeper, the germinal centers become larger, and the B-cells continue to divide actively. The stroma, meanwhile, shows almost no inflammation.
References
Богомильский М. Р. Гипертрофия нёбных миндалин у детей: современные подходы к диагностике и лечению / М. Р. Богомильский, Т. И. Гаращенко // Российская оториноларингология. – 2020. – Т. 19, № 2. – С. 8–15.
Быкова В. П. Лимфоэпителиальные органы в системе местного иммунитета слизистых оболочек / В. П. Быкова // Архив патологии. – 2019. – Т. 81, № 1. – С. 70–76.
Палатина тонзилла : гистологическое строение и иммунологическая функция / Я. А. Накатис [и др.] // Российская оториноларингология. – 2019. – Т. 18, № 4. – С. 86–94.
Сапин М. Р. Иммунная система человека / М. Р. Сапин, Л. Е. Этинген. – М. : Медицина, 2017. – 304 с.
Цыплаков Д. Э. Гистофизиология иммунной системы человека / Д. Э. Цыплаков, С. В. Бойчук // Казанский медицинский журнал. – 2018. – Т. 99, № 6. – С. 938–947.
Юнусов А. С. Морфометрический анализ лимфоидной ткани кольца Пирогова–Вальдейера у детей в норме и при патологии / А. С. Юнусов, Ю. Ю. Русецкий // Вестник оториноларингологии. – 2021. – Т. 86, № 3. – С. 64–70.
Accelerated involution of germinal center in palatine tonsils in IgA nephropathy / Y. Sato [et al.] // PLoS One. – 2024. – Vol. 19, № 5. – e0303257.
Adenoid hypertrophy in children: a narrative review of pathogenesis and clinical relevance / A. Niedzielski [et al.] // BMJ Paediatrics Open. – 2023. – Vol. 7, № 1. – e001710.
Anatomy, Head and Neck, Palatine Tonsil (Faucial Tonsils) / J. M. Arambula [et al.] // StatPearls [Электронный ресурс]. – Treasure Island (FL): StatPearls Publishing, 2023. – URL: https://www.ncbi.nlm.nih.gov/books/NBK538296/
Brandtzaeg P. Immunology of tonsils and adenoids: everything the ENT surgeon needs to know / P. Brandtzaeg // International Journal of Pediatric Otorhinolaryngology. – 2003. – Vol. 67, Suppl. 1. – P. S69–S76.
Brandtzaeg P. Morphology and immunology of the human palatine tonsil / P. Brandtzaeg, K. Kett // Acta Otolaryngologica Supplementum. – 1988. – Vol. 454. – P. 64–69.
Mapping Human Immunity and the Education of Waldeyer’s Ring / C. Domínguez-Conde [et al.] // Annual Review of Genomics and Human Genetics. – 2024. – Vol. 25. – P. 121–147.
Perry M. Immunology of the tonsils / M. Perry, A. Whyte // Immunology Today. – 1998. – Vol. 19, № 9. – P. 414–421.
Plasma cells, plasmablasts, and AID+/CD30+ B lymphoblasts inside and outside germinal centres: details of the basal light zone and the outer zone in human palatine tonsils / H.-J. Radbruch [et al.] // Histochemistry and Cell Biology. – 2020. – Vol. 154, № 1. – P. 55–75.
Tonsillar tissue dynamics across the lifespan: structural and immunological changes / S. K. Howie [et al.] // Frontiers in Immunology. – 2023. – Vol. 14. – Article 1156738.
