PATHOMORPHOFUNCTIONAL STATE OF THE LARRYNGE UNDER NORMAL AND PATHOLOGICAL CONDITIONS IN EXPERIMENTAL LARINGITIS
Keywords:
experiment, larynx, laryngitis, mucous membrane, rabbit.Abstract
Purpose: To study inflammatory processes in the larynx in the dynamics of their development under experimental conditions.
Methods: To assess the morphofunctional state of the larynx under normal and pathological conditions, the organ was studied in 86 adult rabbits weighing 2.0-2.5 kg. All animals were kept under identical conditions on a standard diet with free access to water.
Results obtained: The acute phase of inflammation is observed on days 1-14 of the experiment. On the 1st day of modeling laryngitis, alterative changes are detected in the larynx. On the 7th day of the experiment, an increase in changes was observed in the larynx with a predominance of the exudative phase of inflammation over the alterative one. On the 14th day of the study, the mucous membrane with MPE and MRE was thickened, especially significantly with MRE (almost 1.4 times). Thickening of both the epithelium and the lamina propria underneath them was noted. On the 30th and 60th days of the study, the thickness of the mucous membrane with MPE increases (1.8-1.7 times), and with MRE - by 1.1 and 1.4 times, respectively, compared to the norm. A study of the larynx in the long term after modeling laryngitis (120-180 days) showed the progression of proliferative processes in its wall.
Conclusions: The thickness of the layers of the laryngeal mucosa is not the same in rabbits of different sexes. The stratified squamous and multirow ciliated epithelium in females is thinner, and the lamina propria under the multirow epithelium is thicker than in males.
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Статья поступила в редакцию 12.05.2024; одобрена после рецензирования 21.06.2024; принята к публикации 29.06.2024.
The article was submitted 12.05.2024; approved after reviewing 21.06.2024; accepted for publication 29.06.2024.
Информация об авторах:
Хамидова Фарида Муиновна - д.м.н., доцент. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: xamidova.m.05@mail.ru, https://orcid.org/0000-0001-6084-7025
Исмоилов Жасур Мардонович – к.м.н., ассистент. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: ismoilov-jasur@bk.ru, https://orcid.org/0000-0002-0428-1984
Сулаймонова Мария Жолдасбай кизы – клинический ординатор. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: ismoilov-jasur@bk.ru, https://orcid.org/0000-0002-0428-1984
Information about the authors:
Khamidova Farida Muinovna - candidate of medical sciences, associate professor. Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: xamidova.m.05@mail.ru, https://orcid.org/0000-0001-6084-7025
Ismoilov Jasur Mardonovich - Assistant. Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: ismoilov-jasur@bk.ru, https://orcid.org/0000-0002-0428-1984
Sulaimonova Maria Zholdasbay kizy – clinical resident. Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: ismoilov-jasur@bk.ru, https://orcid.org/0000-0002-0428-1984
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Хамидова Ф.М. — идеологическая концепция работы, провидения эксперимента, написание текста; редактирование статьи;
Исмоилов Ж.М. — сбор и анализ источников литературы, участвуя при провидения эксперимента, написание текста.
Сулайманова М.Ж. - анализ источников литературы.
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Authors' contributions:
Khamidova F.M. — ideological concept of the work, the providence of the experiment, writing the text; article editing;
Ismoilov Zh.M. - collection and analysis of literature sources, participating in the experiment, writing the text.
Sulaymanova M.Zh. - analysis of literature sources.
