LARYNGEAL PAPILLOMATOSIS: A REVIEW OF MODERN METHODS OF DIAGNOSIS AND TREATMENT
Keywords:
Laryngeal papillomatosis, human papillomavirus (HPV), lesional surgeryAbstract
Laryngeal papillomatosis is caused by HPV infection, primarily types 6 and 11, which are also responsible for the development of genital warts. HPV can be transmitted through various routes, including vertical and perinatal contact, which explains the development of LP in children. Clinically, the disease presents with hoarseness, stridor, cough, and, in severe cases, respiratory failure. The juvenile form, detected primarily in children under 5 years of age, has a more aggressive course and requires frequent surgical interventions. The primary cause of the disease is HPV types 6 and 11. The virus infects the respiratory epithelium, causing cell proliferation and papilloma formation. Viral proteins E6 and E7 disrupt cell cycle regulation, promoting the development of benign tumors. The body's immune response plays a key role in controlling infection, and impaired immune regulation is associated with frequent relapses and disease progression. The diagnosis is established by laryngoscopy with visualization of papillomatous growths, histological examination of biopsy material, and molecular diagnostics (PCR) to determine HPV types.
References
Удосконалення методик ендоскопічної мікроларингохірургії із застосуванням високочастотної електрохірургії / Б.І. Павлик, Д.І. Безбах, Є.І. Клочков, Зінченко Ю.М., Багірова І.М. // ЖУРНАЛ ВУШНИХ, НОСОВИХ І ГОРЛОВИХ ХВОРОБ : Науково-практичний двомісячний журнал. - 2013. - N3. - С. 41-45 : фото.цв. . - ISSN 0044-4650
Derkay, C. S., & Bluher, A. E. (2023). Pharmacotherapy for recurrent respiratory papillomatosis: Update January 2023. University of Iowa Health Care. https://medicine.uiowa.edu/iowaprotocols/pharmacotherapy-recurrent-respiratory-papillomatosis-update-january-2023
Broussard, K. C., & Derkay, C. S. (2024). Recurrent respiratory papillomatosis: Current and emerging therapies. Respiratory Research, 25(1), 24. https://doi.org/10.1186/s12931-024-03057-w
Simonyan, K., & Sataloff, R. T. (2024). Recurrent respiratory papillomatosis: A review of current and emerging therapies. International Journal of Pediatric Otorhinolaryngology, 173, 111423. https://doi.org/10.1016/j.ijporl.2023.111423
Smith, R. J. H., & Montone, K. T. (2024). Recurrent respiratory papillomatosis: Pathogenesis and molecular mechanisms. Immunologic Research, 72(3), 297–308. https://doi.org/10.1080/08830185.2024.2425428
Formánek, M., Šteffek, L., & Vojtek, R. (2024). Clinical features and immune dysregulation in recurrent respiratory papillomatosis. European Archives of Oto-Rhino-Laryngology, Advance online publication. https://pubmed.ncbi.nlm.nih.gov/38685530/
Rusan, M., Murer, C., & Rahbar, R. (2023). HPV vaccination and recurrent respiratory papillomatosis: A systematic review. The Laryngoscope, 133(6), 1325–1332. https://doi.org/10.1002/lary.31368
Hartley, B. E., & Hamilton, J. R. (2022). Surgical and adjuvant management of juvenile-onset recurrent respiratory papillomatosis. Pediatric Otolaryngology Clinics of North America, 15(2), 187–203. https://doi.org/10.1016/j.pedoto.2022.01.005
Gelinas, J., & Chadha, N. K. (2022). Role of bevacizumab in the treatment of recurrent respiratory papillomatosis: A meta-analysis. Otolaryngology–Head and Neck Surgery, 167(4), 726–735. https://doi.org/10.1177/01945998221106025
Павлик Б. І., Безбах Д. І., Клочков Є. І., Зінченко Ю. М., Багірова І. М. (2013) Удосконалення методик ендоскопічної мікроларингохірургії із застосуванням високочастотної електрохірургії. Журнал вушних, носових і горлових хвороб. - 2013. - № 3. - С. 41-45
Rizaev JA, Shodmonov AA Optimizing the Surgical Phase of Dental Implants Optimization of the Surgical Phase of Dental Implantation Based on Computer Modeling //Eurasian Medical Research Periodical. – 2022. – T. 12. – S. 84-87.
Irgashev, K. N., & Rizaev, J. A. (2025). Optimization of clinical outcomes in the rehabilitation of patients with non-caries dental lesions manifesting as pathological abrasion. Medical Research Journal, 1(1), 146–151.
Jasim, S. A., Gupta, J., Uthirapathy, S., R., R., Kazmi, S. W., & Rizaev, J. A. (2025). A comprehensive review of immunotherapy in gastrointestinal tumors with a focus on the role of combination therapy with PARP inhibitors. Naunyn-Schmiedeberg’s Archives of Pharmacology, 1–17.
Shakhanova, S. S., & Rakhimov, N. M. (2025). The role of troponin and IL-6 in immunological assessment of sarcopenia in oncological patients. Central Asian Journal of Medical and Natural Science, 6(3), 1229–1233.
