LARINGEAL PAPILLOMATOZ: ZAMONAVIY DIAGNOSTIKA VA DAVOLASH USULLARINING SHARHI
##article.subject##:
Laringeal papillomatoz, inson papillomavirusi (IPV), lezerli jarrohlik##article.abstract##
Laringeal papillomatoz inson papillomavirusi (IPV) infektsiyasidan kelib chiqadi, birinchi navbatda, genital siğillarning rivojlanishi uchun mas'ul bo'lgan 6 va 11 turlari. HPV turli yo'llar bilan, jumladan vertikal va perinatal aloqa orqali yuqishi mumkin, bu bolalarda LP rivojlanishini tushuntiradi. Klinik jihatdan kasallik ovoz xirillash, stridor, yo'tal va og'ir holatlarda nafas olish etishmovchiligi bilan namoyon bo'ladi. Asosan 5 yoshgacha bo'lgan bolalarda aniqlangan balog'atga etmagan shakl yanada tajovuzkor kursga ega va tez-tez jarrohlik aralashuvni talab qiladi. Kasallikning asosiy sababi HPV turi 6 va 11. Virus nafas yo'llarining epiteliysini yuqtirib, hujayralar ko'payishi va papilloma shakllanishiga olib keladi. Virusli oqsillar E6 va E7 hujayra siklini tartibga solishni buzadi, yaxshi o'smalarning rivojlanishiga yordam beradi. Tananing immunitet reaktsiyasi infektsiyani nazorat qilishda asosiy rol o'ynaydi va immunitetni tartibga solishning buzilishi tez-tez qaytalanishlar va kasallikning rivojlanishi bilan bog'liq. Tashxis papillomatoz o'simtalarni vizualizatsiya qilish, biopsiya materialini gistologik tekshirish va HPV turlarini aniqlash uchun molekulyar diagnostika (PCR) bilan laringoskopiya bilan belgilanadi.
Библиографические ссылки
Удосконалення методик ендоскопічної мікроларингохірургії із застосуванням високочастотної електрохірургії / Б.І. Павлик, Д.І. Безбах, Є.І. Клочков, Зінченко Ю.М., Багірова І.М. // ЖУРНАЛ ВУШНИХ, НОСОВИХ І ГОРЛОВИХ ХВОРОБ : Науково-практичний двомісячний журнал. - 2013. - N3. - С. 41-45 : фото.цв. . - ISSN 0044-4650
Derkay, C. S., & Bluher, A. E. (2023). Pharmacotherapy for recurrent respiratory papillomatosis: Update January 2023. University of Iowa Health Care. https://medicine.uiowa.edu/iowaprotocols/pharmacotherapy-recurrent-respiratory-papillomatosis-update-january-2023
Broussard, K. C., & Derkay, C. S. (2024). Recurrent respiratory papillomatosis: Current and emerging therapies. Respiratory Research, 25(1), 24. https://doi.org/10.1186/s12931-024-03057-w
Simonyan, K., & Sataloff, R. T. (2024). Recurrent respiratory papillomatosis: A review of current and emerging therapies. International Journal of Pediatric Otorhinolaryngology, 173, 111423. https://doi.org/10.1016/j.ijporl.2023.111423
Smith, R. J. H., & Montone, K. T. (2024). Recurrent respiratory papillomatosis: Pathogenesis and molecular mechanisms. Immunologic Research, 72(3), 297–308. https://doi.org/10.1080/08830185.2024.2425428
Formánek, M., Šteffek, L., & Vojtek, R. (2024). Clinical features and immune dysregulation in recurrent respiratory papillomatosis. European Archives of Oto-Rhino-Laryngology, Advance online publication. https://pubmed.ncbi.nlm.nih.gov/38685530/
Rusan, M., Murer, C., & Rahbar, R. (2023). HPV vaccination and recurrent respiratory papillomatosis: A systematic review. The Laryngoscope, 133(6), 1325–1332. https://doi.org/10.1002/lary.31368
Hartley, B. E., & Hamilton, J. R. (2022). Surgical and adjuvant management of juvenile-onset recurrent respiratory papillomatosis. Pediatric Otolaryngology Clinics of North America, 15(2), 187–203. https://doi.org/10.1016/j.pedoto.2022.01.005
Gelinas, J., & Chadha, N. K. (2022). Role of bevacizumab in the treatment of recurrent respiratory papillomatosis: A meta-analysis. Otolaryngology–Head and Neck Surgery, 167(4), 726–735. https://doi.org/10.1177/01945998221106025
Павлик Б. І., Безбах Д. І., Клочков Є. І., Зінченко Ю. М., Багірова І. М. (2013) Удосконалення методик ендоскопічної мікроларингохірургії із застосуванням високочастотної електрохірургії. Журнал вушних, носових і горлових хвороб. - 2013. - № 3. - С. 41-45
Rizaev JA, Shodmonov AA Optimizing the Surgical Phase of Dental Implants Optimization of the Surgical Phase of Dental Implantation Based on Computer Modeling //Eurasian Medical Research Periodical. – 2022. – T. 12. – S. 84-87.
Irgashev, K. N., & Rizaev, J. A. (2025). Optimization of clinical outcomes in the rehabilitation of patients with non-caries dental lesions manifesting as pathological abrasion. Medical Research Journal, 1(1), 146–151.
Jasim, S. A., Gupta, J., Uthirapathy, S., R., R., Kazmi, S. W., & Rizaev, J. A. (2025). A comprehensive review of immunotherapy in gastrointestinal tumors with a focus on the role of combination therapy with PARP inhibitors. Naunyn-Schmiedeberg’s Archives of Pharmacology, 1–17.
Shakhanova, S. S., & Rakhimov, N. M. (2025). The role of troponin and IL-6 in immunological assessment of sarcopenia in oncological patients. Central Asian Journal of Medical and Natural Science, 6(3), 1229–1233.
