COMPARISON OF THE CLINICAL AND RADIOLOGICAL EFFICACY OF EPOXY SILERS OF TRADITIONAL COMPOSITION AND WITH ADDITIVES OF QUATERNARY AMMONIUM
Keywords:
endodontic treatment, chronic apical periodontitis, epoxy siler, quaternary ammonium compounds, antimicrobial activity, clinical efficacy, X-ray healing, modified silers, root canal obturationAbstract
The success of endodontic treatment largely depends on thorough sanitation and hermetic obturation of the root canal system; however, the persistence of Enterococcus faecalis often leads to chronic apical periodontitis and relapses. Epoxy sealers provide favorable physico-chemical properties, but their antimicrobial activity is limited; the incorporation of quaternary ammonium compounds enhances the antibacterial potential of the material, which determined the relevance of this study. Objective: to compare the clinical and radiological efficacy of traditional epoxy sealers and sealers with quaternary ammonium additives in the treatment of chronic apical periodontitis. Materials and methods: the study included 20 patients divided into 2 groups (control, n=10 — traditional sealer; main, n=10 — modified sealer). Standard endodontic treatment with lateral condensation obturation was performed; clinical evaluation was carried out at 1, 3, 6, and 12 months, and radiological evaluation at 12 months; statistical analysis was performed using the χ² test (p<0.05). Results: symptoms in the main group occurred less frequently and resolved faster; after 12 months, complete healing was observed in 80% of patients compared to 50% in the control group (χ²=4.00; p=0.045). Conclusions: the use of epoxy sealer with quaternary ammonium compounds provides superior clinical and radiological outcomes compared to the traditional sealer, which is associated with its pronounced antimicrobial activity; however, further studies with larger samples and longer follow-up are required.
References
Siqueira JF, Rôças IN. Clinical implications and microbiology of bacterial persistence after treatment procedures. J Endod. 2008;34(11):1291-1301.
Stuart CH, Schwartz SA, Beeson TJ, Owatz CB. Enterococcus faecalis: Its role in root canal treatment failure and current concepts in retreatment. J Endod. 2006;32(2):93-98.
Ørstavik D. Materials used for root canal obturation: technical, biological and clinical testing. Endod Topics. 2005;12:25-38.
Schroeder A, Schilder H. Sealing ability of various obturating materials. Oral Surg Oral Med Oral Pathol. 1971;31(4):603-612.
Eldeniz AU, Erdemir A, Belli S. Evaluation of antibacterial activity of various root canal sealers. J Endod. 2006;32(2):145-149.
Beyth N, Yudovin-Farber I, Bahir R, Domb AJ, Weiss EI. Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans. Biomaterials. 2006;27(21):3995-4002.
Zhang K, Melo MAS, Cheng L, Weir MD, Bai Y, Xu HHK. Effect of quaternary ammonium and silver nanoparticle-containing adhesives on Enterococcus faecalis biofilm viability. J Dent. 2012;40(11):872-880.
Zhou H, Li F, Weir MD, Xu HH. Dental resin with quaternary ammonium and calcium phosphate nanoparticles. J Dent Res. 2013;92(10):943-949.
Silva EJNL, Carvalho NK, Zanon M, Senna PM, De-Deus G, Zaia AA. Push-out bond strength of injectable root canal sealers. Int Endod J. 2016;49(12):1195-1202.
Rizaev JA, Shodmonov AA Optimizing the Surgical Phase of Dental Implants Optimization of the Surgical Phase of Dental Implantation Based on Computer Modeling //Eurasian Medical Research Periodical. – 2022. – T. 12. – S. 84-87.
Irgashev, K. N., & Rizaev, J. A. (2025). Optimization of clinical outcomes in the rehabilitation of patients with non-caries dental lesions manifesting as pathological abrasion. Medical Research Journal, 1(1), 146–151.
Jasim, S. A., Gupta, J., Uthirapathy, S., R., R., Kazmi, S. W., & Rizaev, J. A. (2025). A comprehensive review of immunotherapy in gastrointestinal tumors with a focus on the role of combination therapy with PARP inhibitors. Naunyn-Schmiedeberg’s Archives of Pharmacology, 1–17.
Shakhanova, S. S., & Rakhimov, N. M. (2025). The role of troponin and IL-6 in immunological assessment of sarcopenia in oncological patients. Central Asian Journal of Medical and Natural Science, 6(3), 1229–1233.
Rakhimov, N. M., & Shakhanova, S. Sh. (2025). Omega-3 supplementation in combination therapy for anorexia syndrome in metastatic breast cancer. American Journal of Medicine and Medical Sciences.
