MORPHOLOGICAL AND MORPHOMETRIC CHARACTERISTICS OF BONE TISSUE IN ALLOXAN-INDUCED OSTЕOPATHY AND ITS CORRECTION
Keywords:
morphometry, osteoblasts, osteoclasts, trabecular structure, diabetic osteopathyAbstract
The article presents the results of morphological and morphometric analysis of bone tissue in rats with alloxan-induced diabetes and evaluates the effectiveness of various correction methods (calcium gluconate, sulfated glycosaminoglycans, and their combination). The study examined the trabecular bone structure, osteoblast and osteoclast activity, osteocyte density, trabecular thickness, and trabecular area. The findings demonstrate pronounced structural disturbances of bone tissue in diabetic osteopathy and partial restoration under monotherapy, with the most significant effect observed in combined treatment.
References
Петров С.В., Михайлова Е.А. Аллоксановая модель диабета у лабораторных животных: патогенетические особенности // Проблемы эндокринологии. – 2020. – Т.66, №3. – С.35–42.
Лебедев А.П., Лукьянова Н.Н. Метаболические изменения костной ткани при сахарном диабете // Вестник экспериментальной и клинической медицины. – 2019. – Т.12, №4. – С.45–49.
Shadmanova L.A., Mirdjuraev E.M. Morphological changes in bone tissue under experimental diabetes // Medical Morphology. – 2023. – Vol.7, No.2. – P.21–28.
Calvi L.M., Adams G.B. Osteoimmunology and endocrine cross-talk in bone metabolism // Journal of Bone and Mineral Research. – 2022. – Vol.37, No.5. – P.880–894.
Rizaev, J. A., Vohidov, E. R., & Nazarova, N. S. (2024). The importance of the clinical picture and development of the condition of periodont tissue diseases in pregnant women. Central Asian Journal of Medicine, 85–90.
Khazratov, A. I., Rizaev, J. A., & Ganiev, A. A. (2024). Epidemiological assessment of the incidence and mortality of oral cancer. Eurasian Journal of Medical and Natural Sciences, 4(12), 99–103.
Shakhanova, S. S., & Rakhimov, N. M. (2025). The role of troponin and IL-6 in immunological assessment of sarcopenia in oncological patients. Central Asian Journal of Medical and Natural Science, 6(3), 1229–1233.
Makhammatkulovich, R. N., Shavkatovna, S. S., & Abdugofurovich, P. O. (2023). Primary multiple skin melanomas. Central Asian Journal of Medical and Natural Science, 4(3), 392–399.
Rizaev, J. A., Rahimov, N. M., & Kadirov, X. X. (2023). Oncoepidemiological assessment of the incidence and mortality of prostate cancer for the period 2015–2020 in the cross section of the Republic of Uzbekistan and individual regions. Open Access Repository, 4(3), 1108–1113.
Kim J.H., Kim K., Kim I.R. Effects of calcium supplementation on bone metabolism in diabetic rats // Metabolism. – 2021. – Vol.116. – P.154700.
