ALLOKSAN OSTЕOPATIYASIDA VA UNING KORREKSIYASIDA MORFOLOGIK VA MORFOMETRIK XARAKTERISTIKASI
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morfometriya, osteoblastlar, osteoklastlar, trabekulyar tuzilma, diabetik osteopatiya##article.abstract##
Maqolada alloksan bilan induksiya qilingan diabet modeli bo‘yicha kalamushlarda suyak to‘qimasining morfologik va morfometrik tahlili natijalari hamda turli korreksiya usullarining (kalsiy glyukonat, sulfatlangan glikozaminoglikanlar va ularning kombinatsiyasi) samaradorligi keltirilgan. Tadqiqotda suyakning trabekulyar tuzilmasi, osteoblastlar va osteoklastlar faolligi, osteotsitlar zichligi, suyak balkalari qalinligi hamda trabekulalar maydoni baholandi. Olingan natijalar diabetik osteopatiya sharoitida suyak to‘qimasi tuzilmasining jiddiy buzilishlarini va monoterapiya holatida qisman tiklanishini, eng yuqori ta’sir esa kombinatsiyalangan muolajada kuzatilishini ko‘rsatadi.
Библиографические ссылки
Петров С.В., Михайлова Е.А. Аллоксановая модель диабета у лабораторных животных: патогенетические особенности // Проблемы эндокринологии. – 2020. – Т.66, №3. – С.35–42.
Лебедев А.П., Лукьянова Н.Н. Метаболические изменения костной ткани при сахарном диабете // Вестник экспериментальной и клинической медицины. – 2019. – Т.12, №4. – С.45–49.
Shadmanova L.A., Mirdjuraev E.M. Morphological changes in bone tissue under experimental diabetes // Medical Morphology. – 2023. – Vol.7, No.2. – P.21–28.
Calvi L.M., Adams G.B. Osteoimmunology and endocrine cross-talk in bone metabolism // Journal of Bone and Mineral Research. – 2022. – Vol.37, No.5. – P.880–894.
Rizaev, J. A., Vohidov, E. R., & Nazarova, N. S. (2024). The importance of the clinical picture and development of the condition of periodont tissue diseases in pregnant women. Central Asian Journal of Medicine, 85–90.
Khazratov, A. I., Rizaev, J. A., & Ganiev, A. A. (2024). Epidemiological assessment of the incidence and mortality of oral cancer. Eurasian Journal of Medical and Natural Sciences, 4(12), 99–103.
Shakhanova, S. S., & Rakhimov, N. M. (2025). The role of troponin and IL-6 in immunological assessment of sarcopenia in oncological patients. Central Asian Journal of Medical and Natural Science, 6(3), 1229–1233.
Makhammatkulovich, R. N., Shavkatovna, S. S., & Abdugofurovich, P. O. (2023). Primary multiple skin melanomas. Central Asian Journal of Medical and Natural Science, 4(3), 392–399.
Rizaev, J. A., Rahimov, N. M., & Kadirov, X. X. (2023). Oncoepidemiological assessment of the incidence and mortality of prostate cancer for the period 2015–2020 in the cross section of the Republic of Uzbekistan and individual regions. Open Access Repository, 4(3), 1108–1113.
Kim J.H., Kim K., Kim I.R. Effects of calcium supplementation on bone metabolism in diabetic rats // Metabolism. – 2021. – Vol.116. – P.154700.
