CLINICAL - ORGANIZATIONAL ASPECTS OF ARTERIAL HYPERTENSION PREVENTION IN THE PRIMARY OUTPATIENT CARE SYSTEM
Keywords:
arterial hypertension, gender differences, screening, primary healthcare, metabolic syndromeAbstract
Arterial hypertension (AH) remains the leading modifiable risk factor for cardiovascular diseases. The aim of the study is to identify gender characteristics of hypertension phenotypes in the working-age population and to develop a screening algorithm for primary healthcare.
The cross-sectional study included 1,798 patients with newly detected hypertension (704 men, 1094 women) from 4 clinics in the Navoi region (Uzbekistan). Analysis of clinical-anamnestic, anthropometric, laboratory data, and quality of life was conducted. A screening algorithm questionnaire with weighting coefficients has been developed.
"Rejuvenation" of hypertension was identified: 30.1% of patients were aged 25-44. Men were characterized by behavioral risk factors (31.5% smoking, 36.2% alcohol consumption), while women were characterized by metabolic risk factors (42.5% obesity, 68.6% dyslipidemia, 38.8% chronic kidney disease). Depression (HADS ≥8) is associated with obesity (OR=2.22; 95% CI 1.78–2.77) and dyslipidemia. An 11-factor screening algorithm has been developed with risk thresholds: low (0–4), moderate (5–9), high (10–14), and very high (≥15).
Two gender phenotypes of hypertension were identified: "behavioral" (men) and "metabolic-psycho-emotional" (women). The proposed screening algorithm is adapted for primary care conditions and requires prospective validation.
References
NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a combined analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021; 398 (10304):957-980. doi:10.1016/S0140-6736 (21) 01330-1
World Health Organization. Hypertension fact sheet. Geneva: WHO; 2023. Available at: https://www.who.int/news-room/fact-sheets/detail/hypertension
Agababyan I. R. et al. Rational hypotensive therapy in the prevention of chronic heart failure in patients with hypertension // Bulletin of Science and Education. – 2020. - No. 24-3 (102). – P. 63-67.
Agababyan I. R., Yusupova Z. K. Opportunities for Effective Control of Arterial Hypertension in Overweight Individuals // Research Focus. - 2023. – Vol. 2. - No. 6. – P. 269-274.
Azirar A., Al-Avdi Yu. M., Gonim E. A. Arterial Hypertension: Modern Approaches to Diagnosis and Measurement // Bulletin of Science. – 2025. – Vol. 4. - No. 5 (86). – P. 1904-1911.
Akhmedjanov N. M. et al. Consensus of Russian experts on the problem of metabolic syndrome in the Russian Federation: definition, diagnostic criteria, primary prevention, and treatment // Cardiovascular therapy and prevention. – 2010. – Vol. 9. - No. 5. – P. 4-11.
Akhmedova D.T., Boynazarova A., Shukurjanova S.M. Study of the prevalence of smoking and arterial hypertension in clinical settings. *Dissertation*. Dushanbe; 2022. 120 p.
Boitsov S. A. et al. Ways to improve outpatient medical care for cardiovascular diseases // National Healthcare. - 2021. – Vol. 2. - No. 4. – P. 5-11.
Burlova N. G., Karaseva L. A. Personalized Approach to Assessing the Risk of Hypertension Development // Modern Problems of Healthcare and Medical Statistics. - 2021. - No. 3. – P. 281-289.
Verbova A.F., Pashentseva A.V., Verbova N.I., et al. Modern approaches to managing cardiovascular risk factors in patients with type 2 diabetes mellitus // Therapeutic Archive. — 2018. - T. 90. - No. 8. - P. 113-117. doi: https://doi.org/10.26442/terarkh2018908113-117
AlRamadneh, T. N., Abdulsahib, W. K., Gajjar, T. B., Hanumanthayya, M., Shukla, S. K., Panigrahi, R., ... & Polatova, D. (2026). Multi-omic biomarkers in cardiovascular disease: Discovery to clinical translation. Clinica Chimica Acta, 121182.
Rizaev , Zh. A., Aghababyan , I. R., Yarasheva , Z. Kh., & Mukhamedova , M. G. (2022). The importance of comorbid conditions in the development of chronic heart failure in elderly and senile patients. Achievements of science and education, (1 (81)), 75-79.
JA Rizaev , I. R. Agababyan , YAIsmoilova ACTIVITIES OF CLINICS
SPECIALIZING IN THE TREATMENT OF PATIENTS WITH CHRONIC HEART DISEASE IN THE WORLD (REFERENCES). Journal of Biomedicine and Practice. 2021, vol. 6, issue 6, pp. 184-191
Makhmonov L.S., Rizaev Zh.A., Gadaev A.G. HELICOBACTER PYLORI AND ITS IMPORTANCE IN THE DEVELOPMENT OF ANEMIA ASSOCIATED WITH IRON DEFICIENCY AND VITAMIN B12 // Problems of biology and medicine. - 2021. No. 5. Volume . 130. - S. 215-218.
Rizaev A. Jhasur , Makhmonov S. Lutfulla , Gadaev G. Abdugaffor , Turakulov I. Rustam. Assessment of external factors involved in prediction of iron deficiency anemia associated with Helicobacter Pylori. Journal of Biomedicine and Practice. 2022, vol.7, issue 4, pp. 436-446
Rizaev , Zh ., & Yunuskhanova , K. (2021). Pathobiological interactions of rheumatoid arthritis and periodontal disease. Medicine and Innovation, 1(2), 37–40.
Alimdjanovich , Rizayev Jasur , Agababyan Irina Rubenovna , and Ismoilova Yulduz Abduvokhidovna . "SPECIALIZED CENTER FOR THE PATIENTS WITH CHRONIC HEART FAILURE-EXTENSION OF LIFE." Questions Sciences And Education 22 (147) (2021): 14-24.
