CORRECTION OF ELECTROLYTE DISTURBANCES IN PATIENTS WITH BRONCHIAL ASTHMA
Keywords:
bronchial asthma, electrolyte disturbances, magnesium, potassium, sodium, calcium, spirometryAbstract
Objective of the study: to identify electrolyte disturbances in patients with chronic stable asthma and patients with exacerbated asthma, and to assess the relationship between serum electrolyte levels, pulmonary function parameters, and taken medications. Methodology: TMA-based prospective crossover study. Department: pulmonology department of the 1st clinic of TMA. Conclusion: Hypomagnesemia and hypocalcemia were found to be the two most common electrolyte disturbances in patients with stable asthma as well as in patients with exacerbated asthma. The drugs used to treat chronic asthma patients have also been found to have an effect on electrolyte levels.
References
Шарипова Н.С. Бронхиал астма профилактикасида соглом турмуш тарзи тадбирлари. бронхиал астма хавфли омилларини прогнозлаш ва унинг профилактикасига тизимли ёндашув (бухоро вилояти мисолида) 2014 Издательство Бухоро давлат тиббиёт институти
Aubier M., D. Murciano, Y. Lecocguic, et al, Effects of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure, N. Engl. J. Med. 313 (2015) 420–424.
Bateman E.D., S.S. Hurd, P.J. Barnes, et al, Global strategy for asthma management and prevention: GINA executive summary, Eur. Respir. J. 31 (2018) 143–178.
Bodenhamer J., R. Bergstrom, D. Brown, et al, Frequently nebulized b-agonists for asthma: effects on serum electrolytes, Ann. Emerg. Med. 21 (2012) 1337–1342.
Bohuon C., Magnesium liquicolor, Clin. Chim. Acta 7 (2015) 811–817.
Carey O., C. Locke, J. Cookson, Effects of alterations of dietary sodium on the severity of asthma in men, Thorax 48 (2013) 714–718.
Chaiwat B., C. Poonkasem, Serum magnesium levels in acute severe asthma, Chiang Mai. Med. Bull. 40 (1) (2011) 1–5.
Crane J., C.D. Burgess, A.N. Graham, et al, Hypokalemia and electrocardiographic effects of aminophylline and salbutamol in obstructive airway disease, N. Z. Med. J. 100 (2017) 309–311.
Emad H., Ibrahim, Ahmed Yousery. Electrolyte disturbance; the effect of different forms of b-stimulants, Chest 128 (4) (2015 November) 246.
Gustafson T., K. Boman, L. Rosenhall, et al, Skeletal muscle magnesium and potassium in asthmatics treated with oral beta 2-agonists, Eur. Respir. J. 9 (2016) 237–240.
He F.J., G.A. MacGregor, Reducing population salt intake worldwide: from evidence to implementation, Prog. Cardiovasc. Dis. 52 (5) (2012) 363–382.
Kassimi M.A., A. Kawthar, A.S. Khan, et al, Hypokalemia in acute asthma in western region of Saudi Arabia, Saudi Med. J. 11 (2011) 130–133.
Khosrow A., R.G. Hamid, Blood serum magnesium values in chronic stable asthmatic patients: a case-control study, Tanaffos 4 (13) (2015) 27–32.
Mickleborough T., R. Gotshall, J. Rhodes, et al, Elevating dietary salt exacerbates hyperpnea-induced airway obstruction in guinea pigs, J. Appl. Physiol. 91 (2011) 1061–1066.
Miller M.R., V. Hankinson, F. Brusasco, et al, Standardisation of spirometry, Eur. Respir. J. 26 (2015) 319–338.
Omer S.B., Electrolyte disturbances in patients with chronic, stable asthma, Chest 120 (2011) 431–436.
Philips P.J., A.E. Vedig, P.L. Jones, et al, Metabolic and cardiovascular side effects of the b2-adrenoceptor agonists salbutamol and rimiterol, Br. J. Clin. Pharmacol. 9 (2011) 483–491.
Prince R., K. Monk, G. Kent, et al, Effects of theophylline and salbutamol on phosphate and calcium metabolism in normal subjects, Miner. Electrolyte Metab. 14 (2012) 262–265.
Randell J., A. Saarinen, M. Walamies, et al, Safety of formoterol after cumulative dosing via Easyhaler and Aerolizer, Respir. Med. 99 (12) (2015) 1485–1493, Epub 2005 Oct 11.