ASSOCIATION OF RS2275913 IL-17 A-GENE POLYMORPHISM IN CIRRHOSIS OF VIRAL ETIOLOGY B AND C
Keywords:
Вирусный этиологический цирроз печени, полиморфизм генов, аллель, хронический гепатитAbstract
According to the World Health Organization, 58 million people have chronic hepatitis C, of which about 1.5 million are newly identified infections and there are about 300,000 deaths each year. About 3.2 million adolescents and children are infected with chronic hepatitis C. Worldwide, mortality from liver disease is about 2 million per year, of which about 1 million are caused by cirrhosis of the liver and about 1 million are caused by complications of viral hepatitis and hepatocellular carcinoma. Currently, the prevalence of cirrhosis as a complication of viral hepatitis has increased to 28.7%. In recent years and in our region, there has been a significant increase in liver cirrhosis due to viral hepatitis. The aim of the study is to identify the polymorphism of the IL-17 A gene in healthy individuals and in patients with viral cirrhosis B and C.
Study materials: 40 patients with liver cirrhosis with the etiology of viral hepatitis B and 32 with the etiology of viral hepatitis C were included in the study. The control group consisted of 28 healthy persons. For the first time, the study identified polymorphism, multiple alleles, and haplotypic associations of the IL-17 A gene in healthy individuals and cirrhotic liver patients with the etiology of viral hepatitis B and C.
References
Mohebbi SR et al. Molecular epidemiology of hepatitis B virus in Iran. Clin Microbiol Infect. 2008 Sep;14(9):858-66.
Xi XE et al. Interleukin-17A and interleukin-17F gene polymorphisms and hepatitis B virus-related hepatocellular carcinoma risk in a Chinese population. Med Oncol. 2015 Jan;32(1):355.
Ge J, Yu YZ, et al. IL-17A G197A gene polymorphism contributes to susceptibility for liver cirrhosis development from patients with chronic hepatitis B infection in Chinese population. Int J Clin Exp Med. 2015 Jun 15;8(6):9793-8.
Ren W, Wu Z, Ma R, Liu Z, Wang Y, Wu L, Liu S, Wang Z. Polymorphisms in the IL-17 Gene (rs2275913 and rs763780) Are Associated with Hepatitis B Virus Infection in the Han Chinese Population. Genet Test Mol Biomarkers. 2017 May;21(5):286-291.
Khanizadeh S. et al. Polymorphisms within the Promoter Region of the Gamma Interferon (IFN-γ) Receptor1 Gene are Associated with the Susceptibility to Chronic HBV Infection in an Iranian Population. Hepat Mon. 2012 Nov;12(11):e7283.
Al Kadi M, Monem F. Polymorphism of IFN-γ (+874 T/A) in Syrian patients with chronic hepatitis B. Gastroenterol Hepatol Bed Bench. 2017 Winter;10(1):34-38.
Xu T, Sun M, Wang H. Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection. Biomed Res Int. 2017;2017:9679843.
Behelgardi A, Hosseini SM, Mohebbi SR, Azimzadeh P, Derakhshani S, Karimi K, Sharifian A, Zali MR. A Study on Genetic Association of Interleukin-16 Single Nucleotide Polymorphism (rs1131445) With Chronic Hepatitis B Virus Infection in Iranian Patients. Jundishapur J Microbiol. 2015 Nov 14;8(11):e23411.
Romani S, Hosseini SM, et al. Interleukin-16 gene polymorphisms are considerable host genetic factors for patients' susceptibility to chronic hepatitis B infection. Hepat Res Treat. 2014;2014:790753. doi: 10.1155/2014/790753. Epub 2014 Nov 26.
Zhu S, Zhang H, et al. The correlation between T helper type 17 cells and clinical characters in Chinese paediatric patients with chronic hepatitis B. Clin Exp Immunol. 2013 Mar;171(3):307-12
