VIRUS ETIOLOGIYALI B VA C JIGAR SIRROZIDA IL-17 A GENI - RS2275913 POLIMORFIZMI ASSOSIASIYASI
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Virus etiologiyali jigar sirrozi, gen polimorfizmi, allel, surunkali gepatit##article.abstract##
Butun dunyo Sog`liqni Saqlash tashkilotining ma`lumotiga ko`ra hozirgi kunda 58 million kishi surunkali gepatit C bilan hasta bo`lib, ulardan taxminan 1,5 millioni yangi aniqlangan infeksiya hisoblanadi va har yili 300 000ga yaqin o`lim holati kuzatiladi. Bundan tashqari 3,2 millionga yaqin o`smirlar va bolalar surunkali gepatit C bilan infitstirlangan. Butun dunyoda jigar kasalliklari tufayli o`lim ko`rsatkichi yiliga taxminan 2 millionga to`g`ri keladi, ulardan 1 millionga yaqini jigar sirrozi asoratlari va 1 millionga yaqini virusli gepatit va gepatoselyulyar karsinoma tufayli sodir bo`ladi. Hozirgi davrda virusli gepatitlar tufayli jigar sirrozining tarqalish ko`rsatkichi 28,7 % ga ko`tarildi. Hozirgi davrda bizning mintaqamizda ham virusli gepatitlarga bog`liq, jigar sirrozining sezilarli darajada oshganligi aniqlandi.
Tadqiqotning maqsadi IL-17 A geni polimorfizmini sog`lom kishilar va virus etiologiyali B jigar sirrozi hamda virus etiologiyali C jigar sirrozi bilan hastalangan bemorlarda aniqlash;
Ilmiy tadqiqot materiali sifatida virus etiologiyali B jigar sirrozi bilan hastalangan 40 nafar, virus etiologiyali C jigar sirrozi bilan hastalangan 32 nafar bemorlar va 28 nafar sog`lom shaxslar olindi.
Tadqiqotda ilk bor sog`lom kishilar va virus etiologiyali B va C jigar sirrozi bilan hastalanganlarda IL-17 A genining polimorfizmi, ko`p uchraydigan allellari va gaplotipik assosiasiyalari aniqlandi
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