INFLUENCE OF CONTRICAL AND CLEXANE ON SEX HORMONE VALUES IN EARLY PREGNANCY IN THE ABSENCE OF GENITAL INFECTIONS
Keywords:
interleukins, protease inhibitors, sex hormones, early pregnancy, miscarriage, contrical, clexane.Abstract
The work studied the effect of the complex contrical and heparin on changes in sex hormones in women in the early stages of pregnancy in the absence of genital infections and in the presence of an excessive immune reaction. It was concluded that in women in the early stages of pregnancy, in the absence of genital infections, but in the presence of an excessive pro-inflammatory immune reaction, an imbalance of sex hormones is observed. As well as the potential for unfavorable pregnancy and miscarriages before 12 weeks of pregnancy. The use of preconception treatment with a complex of contrical and clexane helps to reduce the excessive pro-inflammatory immune reaction in the early pregnancy, which can help restore the imbalance of sex hormones, as well as the favorable course of pregnancy in the early stages and the development of a full pregnancy.
References
Call D. R., Remick D. G. Low molecular weight heparin is associated with greater cytokine production in a stimulated whole blood model //Shock. – 1998. – Т. 10. – №. 3. – С. 192-197.
Lever R., Page C. P. Non-anticoagulant effects of heparin: an overview //Heparin-A century of progress. – 2012. – С. 281-305.
Lima M., Rudd T., Yates E. New Applications of Heparin and Other Glycosaminoglycans //Molecules (Basel, Switzerland). – 2017. – Т. 22. – №. 5. – С. E749-E749.
Litov, L., Petkov, P., Rangelov, M., Ilieva, N., Lilkova, E., Todorova, N., ... & Nacheva, G. Molecular mechanism of the anti-inflammatory action of heparin //International Journal of Molecular Sciences. – 2021. – Т. 22. – №. 19. – С. 10730 -10730.
Negri, E. M., Piloto, B. M., Morinaga, L. K., Jardim, C. V. P., Lamy, S. A. E. D., Ferreira, M. A., ... & Deheinzelin, D. Heparin therapy improving hypoxia in COVID-19 patients–a case series //Frontiers in physiology. – 2020. – Т. 11. – С. 573044.
Page C. Heparin and related drugs: beyond anticoagulant activity //ISRN Pharmacology. – 2013. – Т. 2013. – С. 910743-910743.
Soeparwata, R., Hartman, A. R., Frerichmann, U., Stefano, G. B., Scheld, H. H., & Bilfinger, T. V. Aprotinin® diminishes inflammatory processes //International journal of cardiology. – 1996. – Т. 53. – С. S55-S63.
Shakhanova Sh. Sh., Rakhimov M. N. Aspects of sarcopenia syndrome in oncological practice: diagnosis and treatment (literature review) // Journal of Biomedicine and Practice. 2023, vol. 8, issue 3, pp. 406-417
Tassani, P., Augustin, N., Barankay, A., Braun, S. L., Zaccaria, F., & Richter, J. A. High-dose aprotinin modulates the balance between proinflammatory and anti-inflammatory responses during coronary artery bypass graft surgery //Journal of cardiothoracic and vascular anesthesia. – 2000. – Т. 14. – №. 6. – С. 682-686.
Taylor K. M. Antiinflammatory effects of aprotinin //Transfusion Alternatives in Transfusion Medicine. – 2004. – Т. 6. – С. 39-46.
Veraldi, N., Hughes, A. J., Rudd, T. R., Thomas, H. B., Edwards, S. W., Hadfield, L., ... & Yates, E. A. Heparin derivatives for the targeting of multiple activities in the inflammatory response //Carbohydrate polymers. – 2015. – Т. 117. – С. 400-407.
Yan, Y., Ji, Y., Su, N., Mei, X., Wang, Y., Du, S., ... & Xing, X. H. Non-anticoagulant effects of low molecular weight heparins in inflammatory disorders: A review //Carbohydrate polymers. – 2017. – Т. 160. – С. 71-81.
Статья поступила в редакцию 05.01.2024; одобрена после рецензирования 18.02.2024; принята к публикации 20.02.2024.
The article was submitted 05.01.2024; approved after reviewing 18.02.2024; accepted for publication 20.02.2024.
Информация об авторах:
Мухитдинова Камола Ойбековна, PhD, ассистент кафедры «Акушерство и гинекология-2» Андижанский государственный медицинский институт, Андижан, Узбекистан kamosha.muhitdinova@mail.ru (ORCID: 0000-0003-1322-4292) +998(91) 479 40 90
Алейник Владимир Алексеевич д.м.н., профессор, Директор Андижанского филиала НИИ иммунологии и геномики человека Академии наук Республики Узбекистан aleynik.vladimir@mail.ru (ORCID:007-0741-7804-4687) +998(90) 211 63 21
Бабич Светлана Михайловна к.м.н., доцент кафедры «Социальная гигиена и менеджмент здоровья» Андижанский государственный медицинский институт, Андижан bsm959@mail.ru (ORCID: 0000-0002-9811-9055)
Негматшаева Хабиба Набиевна к.м.н., доцент, заведующая кафедрой «Акушерство и гинекология-2» Андижанский государственный медицинский институт, Андижан negmatshaeva-@inbox.ru (ORCID: 0000-0002-3146-4954)+998(91) 612 33 36
Юлдашева Aзада Собировна к.м.н., доцент кафедры «Акушерство и гинекология-2» Андижанский государственный медицинский институт, Андижан yuldasheva_azada@inbox.ru (ORCID: 0000-0003-2613-5782) +998(90) 258 01 09
Джураев Бобуржон Мукумжон Ўгли младший научный сотрудник Андижанского филиала НИИ иммунологии и геномики человека Академии наук Республики Узбекистан
mirzo-bobur91@mail.ru (ORCID: 0000-0003-3706-2865)
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Мухитдинова К.О. — идеологическая концепция работы, написание текста
Алейник В.А. — написание текста, редактирование статьи;
Бабич С.М. - анализ источников
Негматшаева Х.Н. - сбор литературы.
Юлдашева А.С. – сбор материала
Джураев Б.М. – анализ материала
Information about the authors:
Mukhitdinova Kamola Oybekovna, PhD, assistant of the department of “Obstetrics and Gynecology-2” Andijan State Medical Institute, Andijan, Uzbekistan (hidden) (ORCID: 0000-0003-1322-4292) +998(91) 479 40 90
Aleynik Vladimir Alekseevich Doctor of Medical Sciences, Professor, Director of the Andijan branch of the Research Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan (hidden) (ORCID:007-0741-7804-4687) +998(90) 211 63 21
Babich Svetlana Mikhailovna Candidate of Medical Sciences, Associate Professor of the Department of Social Hygiene and Health Management, Andijan State Medical Institute, Andijan (hidden) (ORCID: 0000-0002-9811-9055)
Negmatshaeva Habiba Nabievna Candidate of Medical Sciences, Associate Professor, Head of the Department of Obstetrics and Gynecology-2 Andijan State Medical Institute, Andijan (hidden) (ORCID: 0000-0002-3146-4954)+998(91) 612 33 36
Yuldasheva Azada Sobirovna Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics and Gynecology-2. Andijan State Medical Institute, Andijan (hidden) (ORCID: 0000-0003-2613-5782) +998(90) 258 01 09
Juraev Boburjon Mukumjon Ўgli junior researcher of the Andijan branch of the Research Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan
(hidden) (ORCID: 0000-0003-3706-2865)
Sources of funding: The work did not have special funding.
Conflict of interest: The authors declare that there are no obvious or potential conflicts of interest related to the publication of this article.
Authors' contributions:
Mukhitdinova K.O. — ideological concept of work, text writing
Aleynik V.A. — writing the text, editing the article;
Babich S.M. - analysis of sources
Negmatshaeva Kh.N. - collection of literature.
Yuldasheva A.S. – collection of material
Dzhuraev B.M. – material analysis
