IMPROVEMENT OF ANTI-INFLAMMATORY THERAPY FOR PATIENTS AFTER CORONARY ARTERY BYPASS GRAFTING
Keywords:
coronary heart disease, coronary artery bypass grafting, cardiopulmonary bypass, cytokines, ulinastatin, systemic inflammatory reaction syndromeAbstract
An inflammatory response is likely to develop in all cardiac surgical patients operated on with or without cardiopulmonary bypass (CPB). With prolonged cardiac surgery and CPB, clinical manifestations develop in the form of increased capillary permeability, resulting in widespread edema, impaired gas exchange, cerebral, renal and hepatic dysfunctions.In this study, patients were divided into two groups, depending on the use of ulinastatin: group 1 (main) n= 35 patients who used ulinastatin in the intraoperative and early postoperative periods; Group 2 (control) – n = 30 patients who did not use ulinastatin in the intraoperative and early postoperative periods. In the complex of postoperative anti-inflammatory therapy to prevent organ damage and multiple organ dysfunction, it is necessary to include the use of a broad-spectrum protease inhibitor ulinastatin at a dose of 100,000 IU in 500 ml of 5% glucose solution or 0.9% sodium chloride intravenously drip for 1-2 hours on the 1st, 3rd day. Against the background of the use of ulinastatin, there was a decrease in the number of proinflammatory cytokines, in particular IL-6, in patients of the main group by 8±1.6 pg/ml (p<0.05), and in the control group there was an increase in the content of IL-6 by 15±3.6 pg/ml (p>0.05). Thus, the analysis shows a beneficial effect of ulinastatin on mortality, the frequency of postoperative complications, or the duration of stay in the intensive care unit after coronary artery bypass surgery.
References
Matlubov, M. M., Yusupov, J. T., Mallayev, S. S., & Khamrayev, K. H. (2020). Optimization of anesthesiological assistance in women with arterial hypertension in hysterectomy. Достижения науки и образования, (5), 82-86.
Matlubov, M., Khamdamova, E., & Yusupov, J. (2020). Tactics of intensive therapy and anesthesia in pregnant women and women in labor infected and sick with covid-19. Journal of Cardiorespiratory Research, 1(SI-1), 66-67. (in Russ).
Mallaev, C., Matlubov, M., & Yusupov, J. (2020). Nutritional support for patients with covid-19 in the intensive care unit. Journal of Cardiorespiratory Research, 1(SI-1), 63-64 (in Russ).
Pardaev, S. K., Sharipov, I. L., & Yusupov, J. T. (2021). Use of combined spinal-epidural anesthesia in gynecological simultaneous operations. Academicia: an international multidisciplinary research journal, 11(2), 1508-1513.
Sharipov, I. L., Pardaev, S. K., & Yusupov, J. T. (2023). Features of the anesthesiological aid for gynecological operations. The journal "The Luminary of Science", 5 (4), 216-222 (in Russ).
Shakhanova Sh. Sh., Rakhimov M. N. Aspects of sarcopenia syndrome in oncological practice: diagnosis and treatment (literature review) // Journal of Biomedicine and Practice. 2023, vol. 8, issue 3, pp. 406-417
Matlubov, M. M., Yusupov, J. T., Saidov, M. A., Zhoniev, S. S., & Mollaev, I. U. (2022). The role of artificial blood circulation in the development of postoperative cognitive dysfunction. Journal of Cardiorespiratory Research, 1(4), 15-20. (in Russ).
Matlubov, M. M., Khamdamova, E. G., & Yusupov, J. T. (2022). The choice of the method of anesthesia in women with concomitant hypertension during hysterectomies. Journal of Integrated Education and Research, 1(5), 49-54. (in Russ).
Rakhimov, A., Negmadzhanov, B., Yusupov, J., Ganiev, F., & Akramov, B. (2018). Simultaneous operations in women. Journal Bulletin of the doctor, 1(4), 116-123. (in Russ).
Muratovich, M. M., Abduvakilovich, M. A., & Tolibovich, Y. J. (2021). Assessment of the degree of preservation of coronary reserves in pregnant women with mitral stenosis. Central Asian Journal of Medical and Natural Science, 2(1), 20-23.
Matlubov, M. M., Yusupov, J. T., & Mukhamedieva, N. U. (2020). Preoperative Preparation Of Elderly Patients With Concomitant Hypertension In The Practice Of Ophthalmic Surgery. The American Journal of Medical Sciences and Pharmaceutical Research, 2(11), 8-15.
Matlubov, M. M., Yusupov, J. T., Mallayev, S. S., & Khamrayev, K. H. (2020). Optimization of anesthesiological assistance in women with arterial hypertension in hysterectomy. Достижения науки и образования, (5), 82-86.
Статья поступила в редакцию 06.01.2024; одобрена после рецензирования 18.02.2024; принята к публикации 20.02.2024.
The article was submitted 06.01.2024; approved after reviewing 18.02.2024; accepted for publication 20.02.2024.
Информация об авторах:
Юсупов Жасур Толибович- ассистент кафедры. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: jasur_brave_1991@mail.ru, https://orcid.org/0000-0001-7289-7601
Матлубов Мансур Муратович - д.м.н., профессор, заведующей кафедрой анестезиологии, реанимации и неотложной медицины. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: mansur.matlubov@gmail.com, https://orcid.org/0000-0001-8596-1430
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Матлубов М.М. — идеологическая концепция работы, написание текста; редактирование статьи;
Юсупов Ж.Т. — сбор и анализ источников литературы, написание текста.
Information about the authors:
Yusupov Zhasur Tolibovich - assistant of the department. Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: jasur_brave_1991@mail.ru , https://orcid.org/0000-0001-7289-7601
Mansur Muratovich Matlubov - MD, Professor, Head of the Department of Anesthesiology, Intensive Care and Emergency Medicine. Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: mansur.matlubov@gmail.com , https://orcid.org/0000-0001-8596-1430
Sources of funding: The work did not have special funding.
Conflict of interest: The authors declare the absence of obvious and potential conflicts of interest related to the publication of this article.
Contribution of the authors:
Matlubov M.M. — the ideological concept of the work, writing the text; editing the article;
Yusupov J.T. — collection and analysis of literature sources, writing a text.
