VEGF-A VASCULAR ENDOTHELIUM GROWTH FACTOR IN NEW CORONAVIRUS INFECTION COVID-19
Keywords:
COVID 19, pneumonia, inflammatory markers, vascular endothelial growth factor VEGF – AAbstract
We conducted a prospective analysis of 163 patients with the new coronavirus infection COVID-19 hospitalized at the infectious diseases hospital of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases and the Samarkand Regional Specialized Medical Center for the period 2020-2022, depending from the severity of the condition. The possibilities of using markers of vascular endothelial growth factor VEGF - A as predictors of severity in patients with COVID 19 complicated by pneumonia were studied. In selected patients with severe and moderate COVID 19, there is an increase in the level of inflammatory markers and vascular endothelial growth factor VEGF-A in the acute period and continue to remain within high values at the time of discharge in patients with severe disease. It has also been found to be associated with oxygen saturation levels, procalcitonin levels, ferritin levels, C-reactive protein (CRP) and the amount of hemoglobin in the blood. The presence of a connection between the level of VEGF-A and markers of inflammation in the blood confirms its role as a biomarker of inflammation, the development of endothelial dysfunction with disease progression in the period of early convalescence.
References
Roitman, E. V. (2021). Restoration of endothelial function during the new coronavirus infection COVID-19 (literature review). Medical Council, (14), 78-86. (in Russ).
Yupatov, E. Yu., Kurmanbaev, T. E., & Timoshkova, Yu. L. (2022). Current understanding of vascular endothelial function and dysfunction. Literature review.-2022.–2022. (in Russ).
Ackermann, M., Verleden, S. E., Kuehnel, M., Haverich, A., Welte, T., Laenger, F., ... & Jonigk, D. (2020). Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. New England Journal of Medicine, 383(2), 120-128. (in Russ).
Cao, Y. (2021, October). The impact of the hypoxia‐VEGF‐vascular permeability on COVID‐19‐infected patients. In Exploration (Vol. 1, No. 2, p. 20210051). (in Russ).
Ilchenko, L. Y., Nikitin, I. G., & Fedorov, I. G. (2020). COVID-19 and liver damage. The Russian Archives of Internal Medicine, 10(3), 188-197. (in Russ).
Статья поступила в редакцию 05.01.2024; одобрена после рецензирования 18.02.2024; принята к публикации 20.02.2024.
The article was submitted 05.01.2024; approved after reviewing 18.02.2024; accepted for publication 20.02.2024.
Информация об авторах:
Таджиева Нигора Убайдуллаевна - д.м.н., доцент, Республиканский специализированный научно-практический медицинский центр эпидемиологии, микробиологии, инфекционных и паразитарных заболеваний, кафедра инфекционных и детских инфекционных болезней Ташкентской медицинской академии; заместитель директора Республиканского специализированного научно-практического медицинского центра эпидемиологии, микробиологии, инфекционных и паразитарных заболеваний Ташкент. Узбекистан. е-mail: n.tadjieva17091073@gmail.com, ORCID: https://orcid. org/0000-0001-8739-6252
Ахмедова Халида Юлдашевна – д.м.н., Доцент, заведующая лабораторией иммунологии инфекционных заболеваний Республиканского специализированного научно-практического медицинского центра эпидемиологии, микробиологии, инфекционных и паразитарных заболеваний. Ташкент. Узбекистан. e-mail: akhmedova1957@mail.ru,
ORCID: http://orcid.org/0009-0008-4159-6564.
Самибаева Умида Хуршидовна – ассистент, Самаркандский государственный медицинский университет, Факультет последипломного образования курса
“ Инфекционные болезни”. Самарканд, Узбекистан. e-mail: umida.samibayeva@gmail.com, ORCID: https://orcid.org/0009-0006-8434-2981.
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Таджиева Н.У. — идеологическая концепция работы, написание текста; редактирование статьи;
Ахмедова Х.Ю.- статистическая обработка материала, редактирование статьи.
Самибаева У.Х.. — сбор и анализ источников литературы, написание текста.
Information about the authors:
Tadzhieva Nigora Ubaydullaevna - Doctor of Medical Sciences, Associate Professor, Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Department of Infectious and Children's Infectious Diseases of the Tashkent Medical Academy; Deputy Director of the Republican Specialized Scientific and Practical Medical Center for Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent. Uzbekistan. e-mail: n.tadjieva17091073@gmail.com, ORCID: https://orcid. org/0000-0001-8739-6252.
Khalida Yuldashevna Akhmedova – Doctor of Medical Sciences, Associate Professor, Head of the Laboratory of Immunology of Infectious Diseases of the Republican Specialized Scientific and Practical Medical Center for Epidemiology, Microbiology, Infectious and Parasitic Diseases. Tashkent. Uzbekistan. e-mail: akhmedova1957@mail.ru, ORCID: http://orcid.org/0009-0008-4159-6564.
Samibaeva Umida Khurshidovna – assistant, Samarkand State Medical University, Faculty of Postgraduate Education course “Infectious diseases”. Samarkand, Uzbekistan. e-mail: umida.samibayeva@gmail.com, ORCID: https://orcid.org/0009-0006-8434-2981.
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Tadzhieva N.U. — ideological concept of the work, writing the text; article editing;
Akhmedova Kh.Yu. - statistical processing of the material, editing the article.
Samibaeva U.Kh. - collection and analysis of literature sources, writing the text.
