MORPHOLOGICAL CHANGES OF THE KIDNEYS OF RATS IN DIABETES INDUCED BY STREPTOZOTOCIN
Keywords:
morphology, morometry, kidney, ball, hyperglycemic nephropathies, atrophy, sclerosis, diabetes mellitus with streptothiazineAbstract
Type 1 diabetes mellitus (DM), more often type 2, is found in children. Although advanced hyperglycemic nephropathies (GN), such as loss of nephron filtration rate (NFT), do not occur until adulthood, renal biopsies show structural GN within 1.5–5 years after initiation of type 1 QD. shows changes. The earliest clinical sign of GN, such as increased urinary albumin excretion, usually appears in childhood and adolescence and is an important opportunity for early GN detection and
treatment. Research in type 1 diabetes has shown that GN is characteristic of a subset of people with diabetes who are at high risk of premature death, which increases the focus on detection, prevention, and treatment of GN. Preliminary studies suggest that youth-onset type 2 diabetes is associated with a higher prevalence of risk factors. Research will help to better understand the risk factors, underlying mechanisms, and treatment options for GN in youth-onset type 2 diabetes.
References
Pettitt DJ, Talton J, Dabelea D, Divers J, Imperatore G, Lawrence JM, Liese AD, Linder B, MayerDavis EJ, Pihoker C, Saidah SH, Standiford DA, Hamman RF for SfDiYSG. Prevalence of diabetes in US youth in 2009: looking for diabetes in youth. Caring for diabetes. 2014;37:402–408.
Imperatore G, Boyle JP, Thompson TJ, Case D, Dabelea D, Hamman RF, Lawrence JM, Liese AD, Liu LL, Mayer-Davis EJ, Rodriguez BL, Standiford D. Predictors of type 1 and type 2 burden. diabetes. . The US population under 20 years of age to 2050: dynamic modeling of incidence, mortality, and population growth. Caring for diabetes. 2012;35:2515–2520.
Groop PH, Thomas MC, Moran JL, Waden J, Thorn LM, Makinen VP, Rosengard-Barlund M, Saraheimo M, Hietala K, Heikkila O, Forsblom C, FinnDiane Study G. Predictors of presence and severity of chronic kidney disease. doers does. All-cause mortality in type 1 diabetes. Diabetes.
;58:1651–1658.
Orchard TJ, Secrest AM, Miller RG, Costacou T. In the absence of kidney disease: 20-year risk of death in type 1 diabetes compared with the general population: a report from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes. 2010;53:2312–2319.
Afkarian M, Sachs MC, Kestenbaum B, Hirsch IB, Tuttle KR, Himmelfarb J, de Boer IH. It increases the risk of death from kidney disease and type 2 diabetes. J Am Soc Nephrol. 2013;24:302– 308.
Amin R, Widmer B, Prevost AT, Schwarze P, Cooper J, Edge J, Marcovecchio L, Neil A, Dalton RN, Dunger DB. Microalbuminuria and risk of progression to macroalbuminuria in a cohort with childhood type 1 diabetes: a prospective observational study. BMJ (Journal of Clinical Research) 2008; 336: 697-701.
Katz A, Caramori ML, Sisson-Ross S, Groppoli T, Basgen JM, Mauer M. Increased cortical interstitial cellular component precedes interstitial fibrosis in type 1 diabetic patients. Kidney Int. 2002;61:2058–2066.
