STREPTOZOTOTSIN ORQALI KELIB CHIQQAN QANDLI DIABETDA KALAMUSH AVLODLARI BUYRAKLARNING MORFOLOGIK O‘ZGARISHLARI
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morfologiya, morometriya, buyrak, koptokcha, giperglikemik nefropatiyalar, atrofiya, skleroz, streptotsiazinli qandli diabet##article.abstract##
Bolalarda, odatda, Qandi diabet(QD)ning 1-turi, ko‘proq 2-turi uchramoqda. Rivojlangan giperglikemik nefropatiyalar (GN), masalan, nefronda filtratsiya tezligi (NFT) yo‘qolishi, balog‘at yoshiga qadar sodir bo‘lmasa -da, buyrak biopsiyalari 1-turdagi QD boshlanganidan keyin 1,5-5 yil ichida GN tarkibiy o‘zgarishlarini ko‘rsatadi. GNning eng erta klinik belgisi, masalan, siydikda albumin ajralishining ko‘payishi, odatda bolalik va o‘smirlik davrida paydo bo‘ladi va erta GNni aniqlash va davolash uchun muhim imkoniyatdir. 1-turdagi diabet masalasida olib borilgan tadqiqotlar shuni ko‘rsatdiki, GN erta o‘lim xavfi yuqori bo‘lgan diabet bilan og‘rigan odamlarning bir qismiga xos, bu GNni aniqlash, oldini olish va davolashga etiborni kuchaytiradi. Dastlabki tadqiqotlar shuni ko‘rsatadiki, yoshlarda boshlangan 2-turdagi QD xavf omillarining tarqalishi yuqoriligi bilan bog‘liq. Yoshlarda boshlangan 2-turdagi QDda GN uchun xavf omillarini, asosiy mexanizmlarini va davolash variantlarni chuqurroq tushunib olish borasida ilmiy tadqiqotlarni olib borishga yordam beradi.
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