CHANGES IN ANTITHROMBIN INDICATORS IN ATRIAL FIBRILLATION

Authors

  • AKHMEDOVA Nilufar Sharipovna
  • RIZAYEVA Malika Jamolovna

Keywords:

Coronary heart disease, atrial fibrillation, thromboembolism, antithrombin, complications

Abstract

Atrial fibrillation (AF) is a very common heart rhythm disorder, which represents a pressing problem in modern arrhythmology. The incidence of AF has increased by 13% over the past 20 years. AF is associated with a high incidence of adverse outcomes, the main ones being thromboembolic complications, the onset of chronic heart failure and other adverse outcomes. Currently, the cause of the formation of blood clots, with the support of anticoagulants, in the cavities of the heart is not reliably known.

References

Kazanova P.V., Basieva M.A., Schwartz V.A. Immune remodeling in the pathogenesis of atrial fibrillation. Annals of arrhythmology. 2023; 20(2): 119-130. (in Russ)

Schnabel R.B., Yin X., Gona P. et al. 50-year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study. Lancet. 2015; 386: 154–62. DOI: 10.1016/S0140-6736(14)61774-8.

Allessie M.A., Ausma J., Schotten U. Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovasc. Res. 2002; 54 (2): 230–46. DOI: 10.1016/s0008-6363 (02)00258-4.

Kazanova P.V., Basieva M.A., Schwartz V.A. Immune remodeling in the pathogenesis of atrial fibrillation. Annals of arrhythmology. 2023; 20(2): 119-130. (in Russ)

Korkushko O.V., Kovalenko A.N. Fibrinolytic blood system in healthy people and elderly patients with coronary heart disease.// Ter. archive./1980./ №8./С.15-19. (in Russ)

Lishnevskaya V.Yu. The role of destabilization of hemovascular homeostasis in the development of myocardial ischemia in patients with coronary heart disease of older age groups.// Ukrainian Therapeutic Journal./2004./№1./ С.98 -103. (in Russ)

Gebekova Z.A., Ivanov I.I., Kudryavtseva A.A., Kolpachkova E.V., Sokolova A.A., Sedov V.P., Napalkov D.A. Possibilities of assessing the hemostasis system in atrial fibrillation and thrombosis of the left auricle. Atherothrombosis. 2022;12(2):103–112. https://doi.org/10.21518/2307-1109-2022-12-2-103-112. (in Russ)

Balandina A.N., Koltsova E.M., Shibekoet A.M., Kuprash A., Ataullakhanov F. Thrombodynamics: a new method to the diagnosis of hemostasis system disorders. Pediatric Hematology/Oncology and Immunopathology. 2018;17(4):114–126. https://doi.org/10.24287/1726-1708-2018-17-4-114-126. (In Russ.)

Vuimo T., Belikov E., Litinskaya O. Efficiency of Thrombodynamics for Analysis of Hemostasis in Case of Transitory Ischemic Attack after Radio-frequency Ablation in a Patient with Paroxysmal Atrial Fibrillation. Am J Med Case Rep. 2015;3(10):333–337. https://doi.org/10.12691/ajmcr-3-10-8.

Boltaev, K. J., & Rizaeva, M. J. (2023). The risk of thromboembolism in atrial fibrillation (review article). Central Asian Journal of Medical and Natural Science, 4(3), 451-454. (In Russ.)

Sh, A. N., & Rizaeva, M. J. (2023). Problems of hemostasis in patients with persistent atrial fibrillation on the background of coronary heart disease. Eurasian Research Bulletin, 21, 1-6.

Статья поступила в редакцию 07.03.2024; одобрена после рецензирования 24.04.2024; принята к публикации 26.04.2024.

The article was submitted 07.03.2024; approved after reviewing 24.04.2024; accepted for publication 26.04.2024

Сведения об авторах:

Ахмедова Нилуфар Шариповна, д.м.н., доцент кафедры «Гематологии и клинической лабораторной диагностики» Бухарского государственного медицинского института, +998 91 409 78 27, https://orcid.org/0009-0002-3864-3987

Ризаева Малика Жамоловна, ассистент кафедры «Анестезиология и реаниматология, детская анестезиология и реаниматология» Бухарского государственного медицинского института malikarizaev1990@gmail.com +998914001230 https://orcid.org/0009-0008-6649-4708

Источники финансирования: Работа не имела специального финансирования.

Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.

Вклад авторов:

Ахмедова Н.Ш. — идеологическая концепция работы, написание текста; редактирование статьи;

Ризаева М.Ж. — сбор и анализ источников литературы, написание текста.

Information about authors:

Akhmedova Nilufar Sharipovna, MD, Associate Professor of the Department of Hematology and Clinical Laboratory Diagnostics, Bukhara State Medical Institute, +998 91 409 78 27, https://orcid.org/0009-0002-3864-3987

Rizaeva Malika Zhamolovna, assistant at the Department of Anesthesiology and Reanimatology, Pediatric Anesthesiology and Resuscitation, Bukhara State Medical Institute malikarizaev1990@gmail.com +998914001230 https://orcid.org/0009-0008-6649-4708

Sources of funding: The work did not have special funding.

Conflict of interest: The authors declare that there are no obvious or potential conflicts of interest related to the publication of this article.

Authors' contributions:

Akhmedova N.Sh. — ideological concept of the work, writing the text; article editing;

Rizaeva M.J. — collection and analysis of literature sources, writing text.

Published

2024-06-03