MORPHOLOGICAL CRITERIA OF AGGRESSIVENESS IN PHYLLODES TUMORS OF THE BREAST IN THE CONTEXT OF PREDICTING CLINICAL OUTCOMES
Keywords:
phyllodes tumors, morphology, aggressiveness, Ki-67, prognosis, mitoses, hypercellularity, immunohistochemistryAbstract
This review article analyzes the morphological and immunohistochemical criteria of aggressiveness in phyllodes tumors of the breast. Key prognostic parameters-including cellular atypia, mitotic activity, stromal hypercellularity, Ki-67, and p53 expression-are examined in relation to clinical outcomes. Differences in interpretation among authors are highlighted, emphasizing the need for standardized diagnostic criteria and prognostic assessment strategies.
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