MOLECULAR AND REGENERATIVE INNOVATIONS IN GYNECOLOGY: INTEGRATION PERSPECTIVES IN THE POST-COVID ERA

Authors

  • RIZAEVA Malika Abdumanonovna
  • KATTAXODJAEVA Makhmuda Khamdamovna
  • RIZAEV Jasur Alimdjanovich

Keywords:

exosomes, mesenchymal stem cells, gynecologic oncology, artificial intelligence, COVID-19, epigenetics, digital pathology, reproductive health

Abstract

This review explores the convergence of molecular, regenerative, and digital technologies in gynecology following the COVID-19 pandemic. Emphasis is placed on exosome-based liquid biopsy, mesenchymal stem cell therapy, AI-driven diagnostics, and epigenetic impacts. These advances present significant potential for improving cancer detection, fertility restoration, and personalized gynecologic care. The article also highlights the need for ethical governance, data security, and regulatory oversight to ensure safe integration into clinical practice.

References

Akazawa, M., & Hashimoto, K. (2021). Artificial intelligence in gynecologic cancers: Current status and future challenges - A systematic review. Artificial intelligence in medicine, 120, 102164. https://doi.org/10.1016/j.artmed.2021.102164

Alvero R. (2022). Do I really need to see my doctor? A changing paradigm in the physician-patient relationship in the time of COVID-19 and telehealth. Fertility and sterility, 117(4), 688–689. https://doi.org/10.1016/j.fertnstert.2022.02.002

Anderson, K. L., Coskun, R., Martin, C. E., Jimenez, P. T., & Omurtag, K. (2021). PATIENT SATISFACTION WITH TELEMEDICINE VISITS FOR REPRODUCTIVE ENDOCRINOLOGY PATIENTS IN THE ERA OF COVID-19. Fertility and Sterility, 116(3), e33–e34. https://doi.org/10.1016/j.fertnstert.2021.07.099

Anderson, K., Coskun, R., Jimenez, P., & Omurtag, K. (2022). Satisfaction with new patient telehealth visits for reproductive endocrinology patients in the era of COVID-19. Journal of assisted reproduction and genetics, 39(7), 1571–1576. https://doi.org/10.1007/s10815-022-02539-4

Balough, J. L., & Moalli, P. (2024). Regenerative Medicine in Gynecology. Obstetrics and gynecology, 143(6), 767–773. https://doi.org/10.1097/AOG.0000000000005590

Brandão, M., Mendes, F., Martins, M., Cardoso, P., Macedo, G., Mascarenhas, T., & Mascarenhas Saraiva, M. (2024). Revolutionizing Women’s Health: A Comprehensive Review of Artificial Intelligence Advancements in Gynecology. Journal of Clinical Medicine, 13(4), 1061. https://doi.org/10.3390/jcm13041061

Brownell, D., Chabaud, S., & Bolduc, S. (2022). Tissue Engineering in Gynecology. International Journal of Molecular Sciences, 23(20), 12319. https://doi.org/10.3390/ijms232012319

Cantor, A. G., Nelson, H. D., Pappas, M., Atchison, C., Hatch, B., Huguet, N., Flynn, B., & McDonagh, M. (2023). Telehealth for Women's Preventive Services for Reproductive Health and Intimate Partner Violence: a Comparative Effectiveness Review. Journal of general internal medicine, 38(7), 1735–1743. https://doi.org/10.1007/s11606-023-08033-6

Cao, X., Li, W., Wang, T., Ran, D., Davalos, V., Planas-Serra, L., Pujol, A., Esteller, M., Wang, X., & Yu, H. (2022). Accelerated biological aging in COVID-19 patients. Nature communications, 13(1), 2135. https://doi.org/10.1038/s41467-022-29801-8

Chao, L., Lin, E., & Kho, K. (2022). Enhanced Recovery After Surgery in Minimally Invasive Gynecologic Surgery. Obstetrics and gynecology clinics of North America, 49(2), 381–395. https://doi.org/10.1016/j.ogc.2022.02.014

Chatzianagnosti, S., Dermitzakis, I., Theotokis, P., Kousta, E., Mastorakos, G., & Manthou, M. E. (2024). Application of Mesenchymal Stem Cells in Female Infertility Treatment: Protocols and Preliminary Results. Life, 14(9), 1161. https://doi.org/10.3390/life14091161

Dhombres, F., Bonnard, J., Bailly, K., Maurice, P., Papageorghiou, A. T., & Jouannic, J. M. (2022). Contributions of Artificial Intelligence Reported in Obstetrics and Gynecology Journals: Systematic Review. Journal of medical Internet research, 24(4), e35465. https://doi.org/10.2196/35465

Dilday, E. A., Douglas, C. R., & Al-Safi, Z. A. (2022). Telehealth provider experience in reproductive endocrinology and infertility clinics during the COVID-19 pandemic and beyond. Journal of assisted reproduction and genetics, 39(7), 1577–1582. https://doi.org/10.1007/s10815-022-02549-2

Hoang, D. M., Pham, P. T., Bach, T. Q., Ngo, A. T. L., Nguyen, Q. T., Phan, T. T. K., Nguyen, G. H., Le, P. T. T., Hoang, V. T., Forsyth, N. R., Heke, M., & Nguyen, L. T. (2022). Stem cell-based therapy for human diseases. Signal transduction and targeted therapy, 7(1), 272. https://doi.org/10.1038/s41392-022-01134-4

Jiang, Y., Wang, C., & Zhou, S. (2023). Artificial intelligence-based risk stratification, accurate diagnosis and treatment prediction in gynecologic oncology. Seminars in cancer biology, 96, 82–99. https://doi.org/10.1016/j.semcancer.2023.09.005

Kaneko, S., Takasawa, K., Asada, K., Shinkai, N., Bolatkan, A., Yamada, M., Takahashi, S., Machino, H., Kobayashi, K., Komatsu, M., & Hamamoto, R. (2021). Epigenetic Mechanisms Underlying COVID-19 Pathogenesis. Biomedicines, 9(9), 1142. https://doi.org/10.3390/biomedicines9091142

Kgatle, M. M., Lawal, I. O., Mashabela, G., Boshomane, T. M. G., Koatale, P. C., Mahasha, P. W., Ndlovu, H., Vorster, M., Rodrigues, H. G., Zeevaart, J. R., Gordon, S., Moura-Alves, P., & Sathekge, M. M. (2021). COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks. Frontiers in immunology, 12, 752380. https://doi.org/10.3389/fimmu.2021.752380

Liao, Z., Liu, C., Wang, L., Sui, C., & Zhang, H. (2021). Therapeutic Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Female Reproductive Diseases. Frontiers in endocrinology, 12, 665645. https://doi.org/10.3389/fendo.2021.665645

Lin, B., Lei, Y., Wang, J., Zhu, L., Wu, Y., Zhang, H., Wu, L., Zhang, P., & Yang, C. (2021). Microfluidic-Based Exosome Analysis for Liquid Biopsy. Small methods, 5(3), e2001131. https://doi.org/10.1002/smtd.202001131

Lin, M., Lu, Y., & Chen, J. (2022). Tissue-engineered repair material for pelvic floor dysfunction. Frontiers in bioengineering and biotechnology, 10, 968482. https://doi.org/10.3389/fbioe.2022.968482

Maher, M., & Owens, L. (2023). SARS-CoV-2 infection and female reproductive health: A narrative review. Best practice & research. Clinical endocrinology & metabolism, 37(4), 101760. https://doi.org/10.1016/j.beem.2023.101760

Mei, Q., Mou, H., Liu, X., & Xiang, W. (2021). Therapeutic Potential of HUMSCs in Female Reproductive Aging. Frontiers in cell and developmental biology, 9, 650003. https://doi.org/10.3389/fcell.2021.650003

Mennella, C., Maniscalco, U., De Pietro, G., & Esposito, M. (2024). Ethical and regulatory challenges of AI technologies in healthcare: A narrative review. Heliyon, 10(4), e26297. https://doi.org/10.1016/j.heliyon.2024.e26297

Miao, M., Miao, Y., Zhu, Y., Wang, J., & Zhou, H. (2022). Advances in Exosomes as Diagnostic and Therapeutic Biomarkers for Gynaecological Malignancies. Cancers, 14(19), 4743. https://doi.org/10.3390/cancers14194743

Mikhael, S., Gaidis, A., & Gavrilova-Jordan, L. (2021). Regional disparities in access to assisted reproductive technology: assessment of patient satisfaction when employing modern technology to close the gap. Journal of assisted reproduction and genetics, 38(4), 889–894. https://doi.org/10.1007/s10815-020-02027-7

Mongelli, A., Barbi, V., Gottardi Zamperla, M., Atlante, S., Forleo, L., Nesta, M., Massetti, M., Pontecorvi, A., Nanni, S., Farsetti, A., Catalano, O., Bussotti, M., Dalla Vecchia, L. A., Bachetti, T., Martelli, F., La Rovere, M. T., & Gaetano, C. (2021). Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors. International Journal of Molecular Sciences, 22(11), 6151. https://doi.org/10.3390/ijms22116151

Moro, F., Ciancia, M., Zace, D., Vagni, M., Tran, H. E., Giudice, M. T., Zoccoli, S. G., Mascilini, F., Ciccarone, F., Boldrini, L., D'Antonio, F., Scambia, G., & Testa, A. C. (2024). Role of artificial intelligence applied to ultrasound in gynecology oncology: A systematic review. International journal of cancer, 155(10), 1832–1845. https://doi.org/10.1002/ijc.35092

Oliva, A., Grassi, S., Vetrugno, G., Rossi, R., Della Morte, G., Pinchi, V., & Caputo, M. (2022). Management of Medico-Legal Risks in Digital Health Era: A Scoping Review. Frontiers in medicine, 8, 821756. https://doi.org/10.3389/fmed.2021.821756

Parry, J. P., Chen, S. H., Ku, L., Anderson, K., Keller, S. L., Omurtag, K., & Alvero, R. (2022). Is telehealth a valuable resource in reproductive endocrinology and infertility?. Fertility and sterility, 117(4), 690–695. https://doi.org/10.1016/j.fertnstert.2022.02.001

Ra, K., Park, S. C., & Lee, B. C. (2023). Female Reproductive Aging and Oxidative Stress: Mesenchymal Stem Cell Conditioned Medium as a Promising Antioxidant. International Journal of Molecular Sciences, 24(5), 5053. https://doi.org/10.3390/ijms24055053

Rajak, P., Roy, S., Dutta, M., Podder, S., Sarkar, S., Ganguly, A., Mandi, M., & Khatun, S. (2021). Understanding the cross-talk between mediators of infertility and COVID-19. Reproductive biology, 21(4), 100559. https://doi.org/10.1016/j.repbio.2021.100559

Rodríguez-Eguren, A., Gómez-Álvarez, M., Francés-Herrero, E., Romeu, M., Ferrero, H., Seli, E., & Cervelló, I. (2022). Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine. International Journal of Molecular Sciences, 23(24), 15942. https://doi.org/10.3390/ijms232415942

Rakhimov, N. M., & Shakhanova, S. Sh. (2025). Omega-3 supplementation in combination therapy for anorexia syndrome in metastatic breast cancer. American Journal of Medicine and Medical Sciences.

Roy, M., Yang, Y.-P., Bosquet, O., Deo, S. K., & Daunert, S. (2022). Understanding the Role and Clinical Applications of Exosomes in Gynecologic Malignancies: A Review of the Current Literature. Cancers, 14(1), 158. https://doi.org/10.3390/cancers14010158

Saad-Naguib, M. H., Kenfack, Y., Sherman, L. S., Chafitz, O. B., & Morelli, S. S. (2024). Impaired receptivity of thin endometrium: therapeutic potential of mesenchymal stem cells. Frontiers in endocrinology, 14, 1268990. https://doi.org/10.3389/fendo.2023.1268990

Saha, S., Roy, P., Corbitt, C., & Kakar, S. S. (2021). Application of Stem Cell Therapy for Infertility. Cells, 10(7), 1613. https://doi.org/10.3390/cells10071613

Seval, M. M., & Varlı, B. (2023). Current developments in artificial intelligence from obstetrics and gynecology to urogynecology. Frontiers in medicine, 10, 1098205. https://doi.org/10.3389/fmed.2023.1098205

Shrestha, P., Poudyal, B., Yadollahi, S., E Wright, D., V Gregory, A., D Warner, J., Korfiatis, P., C Green, I., L Rassier, S., Mariani, A., Kim, B., Laughlin-Tommaso, S. K., & L Kline, T. (2022). A systematic review on the use of artificial intelligence in gynecologic imaging - Background, state of the art, and future directions. Gynecologic oncology, 166(3), 596–605. https://doi.org/10.1016/j.ygyno.2022.07.024

Skryabin, G. O., Komelkov, A. V., Zhordania, K. I., Bagrov, D. V., Vinokurova, S. V., Galetsky, S. A., Elkina, N. V., Denisova, D. A., Enikeev, A. D., & Tchevkina, E. M. (2022). Extracellular Vesicles from Uterine Aspirates Represent a Promising Source for Screening Markers of Gynecologic Cancers. Cells, 11(7), 1064. https://doi.org/10.3390/cells11071064

Tran, H. P., Nguyen, N. N., Ho, N. T., Tran, T. T., Ly, L. T., Hoang, T. T., Le, D. T., Tzeng, C. R., Vo, V. T., & Tran, L. G. (2024). The impacts of telemedicine on assisted reproduction: a systematic review and meta-analysis. Reproductive biomedicine online, 48(5), 103752. https://doi.org/10.1016/j.rbmo.2023.103752

Valencia, K., & Montuenga, L. M. (2021). Exosomes in Liquid Biopsy: The Nanometric World in the Pursuit of Precision Oncology. Cancers, 13(9), 2147. https://doi.org/10.3390/cancers13092147

Wang, Y. L., Gao, S., Xiao, Q., Li, C., Grzegorzek, M., Zhang, Y. Y., Li, X. H., Kang, Y., Liu, F. H., Huang, D. H., Gong, T. T., & Wu, Q. J. (2024). Role of artificial intelligence in digital pathology for gynecological cancers. Computational and structural biotechnology journal, 24, 205–212. https://doi.org/10.1016/j.csbj.2024.03.007

Wei, Z., Hu, Y., He, X., Ling, W., Yao, J., Li, Z., Wang, Q., & Li, L. (2022). Biomaterializing the advances in uterine tissue engineering. iScience, 25(12), 105657. https://doi.org/10.1016/j.isci.2022.105657

Yu, D., Li, Y., Wang, M., Gu, J., Xu, W., Cai, H., Fang, X., & Zhang, X. (2022). Exosomes as a new frontier of cancer liquid biopsy. Molecular cancer, 21(1), 56. https://doi.org/10.1186/s12943-022-01509-9

Yu, X., Xu, J., Song, B., Zhu, R., Liu, J., Liu, Y. F., & Ma, Y. J. (2024). The role of epigenetics in women's reproductive health: the impact of environmental factors. Frontiers in endocrinology, 15, 1399757. https://doi.org/10.3389/fendo.2024.1399757

Zheng, F., Wang, J., Wang, D., & Yang, Q. (2023). Clinical Application of Small Extracellular Vesicles in Gynecologic Malignancy Treatments. Cancers, 15(7), 1984. https://doi.org/10.3390/cancers15071984

Zhu, J.W., Charkhchi, P. & Akbari, M.R. Potential clinical utility of liquid biopsies in ovarian

Раза, М., Ризаев, Ж., & Джурабекова, А. (2025). Организационно-адаптационные стратегии улучшения социально-психологической интеграции зарубежных учащихся медицинских вузов. Наука и инновация, 3(15), 37–39.

Jasur Rizayev Alimjanovich , Larisa Rubenovna Agababyan , Anvar Ibragimovich Kamalov . AYOLLARDA TUG'RUQDAN KEYINGI QON KETISHLARNI OLDINI OLISH VA ULARGA QARSHI KURASHISH BO'YICHA KO'RSATILAYOTGAN XIZMATLAR SIFATINING MONITORINGINI TASHKIL ETISH // Oriental Renaissance: Innovative, educational, natural and social sciences Volume 1_ ISSUE 10 202 1 p.m. 166-169

Alimjanovich JR, Agababyan LR, Kamalov AI Prevention and Treatment of Postpartum Hemorrhage //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2021. – T. 2. – No. 4. – S. 204-209.

Rizaev Jasur Alimjanovich , Agababyan Larisa Rubenovna , Davlatova Aziza, Ahmedova Aziza Tayirovna , Rasulova Feruza Golibovna , The state of the oral cavity in pre-pregnant women, Journal of reproductive health and uronephrology research 2023, vol. 4, issue 4, pp7-11

Rizaev J. A., Nazarova N. S., Vohidov E. R. HOMILADOR AYOLLARDA PARODONT KASALLIKLARI RIVOJLANISHINING PATOGENETIK JIHATLARI //Журнал гуманитарных и естественных наук. – 2024. – №. 11 [2]. – С. 104-107.

Shavkatovna, S. S., Makhammatkulovich, R. N., & Ugli, M. S. T. (2024). Aspects of sarcopenia syndrome in oncological practice: Diagnosis and treatment. The American Journal of Medical Sciences and Pharmaceutical Research, 6(2).

Shakhanova, S. S., & Rakhimov, N. M. (2025). The role of troponin and IL-6 in immunological assessment of sarcopenia in oncological patients. Central Asian Journal of Medical and Natural Science, 6(3), 1229–1233.

Published

2025-10-31