INFLUENCE OF CHRONIC INTOXICATION WITH THE ORGANOPHOSPHORUS PESTICIDE ANTIO ON THE ACTIVITY OF RAT LYMPHOCYTE ACETYLCHOLINESTERASE
Keywords:
organophosphate pesticides, chronic poisoning, rat lymphocytes, acetylcholinesterase activity, acetylcholinesterase inhibitionAbstract
Chronic poisoning of rats with the organophosphate pesticide antio at doses of 3.5 mg/kg/day and 17.5 mg/kg/day (1/100 and 1/20 LD50, respectively) in the experiment revealed the presence of acetylcholinesterase activity in their lymphocytes. The results of the experiment showed that the activity of acetylcholinesterase is not the same in different subpopulations of lymphoid cells. The revealed dose-dependent inhibition of acetylcholinesterase in rat lymphocytes during chronic administration of the organophosphorus pesticide antio suggests that there may be a previously unknown mechanism of the immunosuppressive effect of organophosphorus compounds, implemented through the interference of these drugs in the processes of neurotransmitter regulation of the functions of lymphoid cells.
References
Анучина А.В. Токсическое действие пестицидов на организм человека и животных // Международный студенческий научный вестник. – 2019. – № 1.
Герунов Т.В., Редькин Ю.В., Герунова Л.К. Иммунотоксичность пестицидов: роль в патологии животных и человека // Успехи современной биологии. – 2011. – Т. 131,
№ 5. – С. 474–482.
Забродский П.Ф. Иммунотоксикология фосфорорганических соединений. - Саратов. Издательство «Саратовский источник». - 2016. - 289 с.
Калоянова-Симеонова Ф. Пестициды. Токсическое действие и профилактика. – Москва: Медицина, 1980. – 304 с.
Розенгарт В.И., Шерстобитов О.Е. Избирательная токсичность фосфорорганических инсектоакарицидов. Сравнительно-биохимические аспекты. - Л.: Наука 1978. - 173 с.
Yuldashev Zhovlon, Abdukhalilov Majid, Rakhimov Nodir, Enikeeva Zulfiya, Ibragimov Shavkat. Study of the antitumor activity of the drug colhametin (k-2) on 2 solid tumors of mice in comparison with a number of cytostatics. // Journal of Biomedicine and Practice. 2022, vol. 7,issue 2, pp.230-235
Ellman, G. L., Courtney, K. D., Anders, V. & Featherstone, R. M. A new and rapid colorometric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7, 88–95 (1961).
Singh, K.D., Labala, R.K., Devi, T.B. et al. Biochemical efficacy, molecular docking and inhibitory effect of 2, 3-dimethylmaleic anhydride on insect acetylcholinesterase. Sci Rep 7, 12483 (2017)
Wang X., Anadón A., Wu Q. et al. Mechanism of Neonicotinoid Toxicity: Impact on Oxidative Stress and Metabolism // Annu. Rev. Pharmacol. Toxicol. – 2018. – Vol. 58. – P. 471–507.
