PROGNOSTIC VALUE OF ADHESION MOLECULES AND INFLAMMATORY MEDIATORS IN THE ACUTE PERIOD OF ISCHEMIC STROKE
Keywords:
Ischemic stroke, ICAM-1, systemic immunoinflammation, neutrophil-lymphocyte ratio, prognosisAbstract
Currently, stroke is one of the most important socio-medical problems. To date, one of the priority areas of research in the field of neurology is the use of biological markers of blood plasma during the development of cerebral ischemia, reflecting various parts of its pathogenesis. Most studies show that inflammation plays a very important role in the development of AIS. Neutrophil-to-lymphocyte (NLN) ratio, lymphocyte-to-monocyte (LMN) ratio, and systemic immunoinflammatory index (UII) are calculated based on platelet, neutrophil, monocyte, and lymphocyte counts and reflect the relationship between innate and adaptive immunity. This study involved 105 patients with acute ischemic stroke; ICAM-1, ys-SRO, UR, NLN and LMN were determined in their blood and it was found that there was a correlation between their concentrations and the 3-month prognosis after ischemic stroke.
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Статья поступила в редакцию 10.09.2023; одобрена после рецензирования 21.10.2023; принята к публикации 25.10.2023.
The article was submitted 10.09.2023; approved after reviewing 21.10.2023; accepted for publication 25.10.2023.
Информация об авторах:
Абдурахмонова Қутлибика Бахтиёр қизи. Докторант кафедры неврологии, Ташкентская Медицинская Академия, Ташкент, Узбекистан. Е-mail: doctor.abdurakhmonova@gmail.com https://orcid.org/0009-0006-2415-8218
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Абдурахмонова Қ.Б. — идеологическая концепция работы, написание текста, сбор и анализ источников литературы.
Information about the authors:
Abdurakhmonova Kutlibika Bakhtiyor kizi. PhD researcher of the Neurology Department, Tashkent Medical Academy, Tashkent, Uzbekistan. Е-mail: doctor.abdurakhmonova@gmail.com https://orcid.org/0009-0006-2415-8218
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Abdurakhmonova K.B. — ideological concept of the work, writing the text, collection and analysis of literature sources.
