TO THE QUESTION OF THE RISK OF POSTMATECTOMIC LYMPHEDEMA IN BREAST CANCER PATIENTS AND ITS RELATIONSHIP WITH CONCOMITANT VASCULAR PATHOLOGY
Keywords:
Polychemotherapy (PCT), breast cancer (BC), radical mastectomy (RM), secondary postmastectomy lymphedema (PL)Abstract
Investigation results of influence of radical mastectomy (RME) combined with lymphatic-venous anastomosis (RМЭ+ЛВА) to the 5-year survival of patients with breast cancer (BC), to current of BC, and to the risk of development secondary postmastectomy limphedema (ВЛ), and to its link with symptoms of atherosclerosis, ischemic illness of heart, coronary sclerosis, stenocardia, vascular diseases of brain, neyrocirculatory dystonia and hypertensive disease (HD) are presented. It is shown that RME+LVA effectively reduces risk SL at patients with BC, not influencing current РМЖ, their 5-year-old дожитие, and that, probably, risk ВЛ is linked to the factors which prevent development of HD.
References
Zalutsky I.V., Antonenkova N.N., Zhukovets A.G. Complex treatment of patients with postmastectomy lymphedema of the limb using lymphatic drainage operations / I.V. // Annals of plastic, reconstructive and aesthetic surgery. - 2002. - No. 4. - P. 50-51(in Russ).
Ivanov O.A. Method for processing a database of cancer patients (survival): Method. Recommendations. – M. – 1997. – p. 97(in Russ).
Kolomiets E. A., Kurmukov I. A., Sandomirskaya A. P., Kashiya Sh. R. Comorbidity in oncology: results of preoperative examination of patients in a specialized oncology clinic / Abstracts of the XXI Russian Oncology Congress. // Malignant tumors. – 2017, T.7, No. 3, 1p. – P.171-172 (in Russ).
Lakin G.F. Biometrics. – M.: Higher. school. – 1990. – 352 p (in Russ).
Magomedov O.M., Magomedova P.O., Magomedov G.M. Cardivascular complications in the treatment of breast cancer // Russian Journal of Cardiology 2010. - No. 1 (81). -– pp. 73-76(in Russ).
Mamedov M.N., Badeinikova K.K., Karimov A.K. Targets for the prevention of comorbidity of cardiovascular diseases and cancer // Russian Journal of Cardiology 2022;27(11): 5235. P.115-120; doi:10.15829/1560-4071-2022-5235; https://russjcardiol.elpub.ru(in Russ).
Collection of standards and clinical protocols for the diagnosis and treatment of malignant cancer / Team of compilers, ed. prof., doctor of medical sciences M.N. Tillyashaikhova. - Tashkent. - 2017. – 254 p.(in Russ).
Strelkov R.B. Statistical tables for express calculations of the standard error and confidence limits at zero or one hundred percent value of experimental and clinical data indicators/MZSSSR, AMNSSSR, Scientific Research Institute of Med. Radiol. - Obninsk, 1982. – 45 p (in Russ).
Uzakov S.M., Dzhuraev M.D., Karimova M.N. Modern ideas about post-matectomy lymphedema, methods of its treatment and prevention (literature review) // Journal of Biomedicine and Practice - No. 1 (2022) – P. 179-188.(in Russ).
Allegra C. Morphologic and functional changes of the microlymphatic network in patients with advancing stages of primary lymphedema / C. Allegra, R. Sarcinella, M. J. Bartolo // Lymphology. - 2002. - Vol. 35. № 3.- P. 114-120.
Asdourian M.S., Skolny M.N., Brunelle C. e.a. Precautions for breast cancer-related lymphoedema: Risk from air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and cellulitis. Lancet Oncol 2016; 17: e392-405.
Aspelund A., Robciuc M.R., Karaman S. e.a. Lymphatic System in Cardiovascular Medicine. Circ. Res. 2016, 118, 515–530.
Cormier J.N., Askew R.L., Mungovan K.S. e.a. Lymphedema beyond breast cancer: A systematic review and meta-analysis of cancer-related secondary lymphedema. Cancer 2010, 116, 5138–5149.
DiSipio T., Rye S., Newman B. e.a. Incidence of unilateral arm lymphoedema after breast cancer: A systematic review and meta-analysis. Lancet Oncol 2013;14:500-15.
Ferguson C.M., Swaroop M.N., Horick N. e.a. Impact of ipsilateral blood draws, injections, blood pressure measurements, and air travel on the risk of lymphedema for patients treated for breast cancer. J Clin Oncol 2016;34:691-8.
Gillespie T.C., Sayegh H.E., Brunelle C.L. e.a. Breast cancer-related lymphedema: risk factors, precautionary measures, and treatments. Gland Surg 2018;7(4):379-403.
Grada A.A., Phillips T.J. (December 2017). "Lymphedema: Diagnostic workup and management". Journal of the American Academy of Dermatology. 77 (6): 995-1006.
Kim M., Kim S.W., Lee S.U. e.a. A model to estimate the risk of breast cancer-related lymphedema: Combinations of treatment-related factors of the number of dissected axillary nodes, adjuvant chemotherapy, and radiation therapy // Int.J.Radiat.Oncol.Biol.Phys., 2013;86:498-503.
Lim H.Y., Thiam C.H., Yeo K.P. e.a. Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL. // Cell Metab., 2013, 17, 671–684.
Lymfo-Veneuse Anastomosen Ter Preventie Van Lymphoedem. University Hospital, Ghent.: https://ichgcp.net/ru/clinical-trials-registry/NCT05601037
Martel C., Li W., Fulp B. e.a. Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice. J. Clin. Investing. 2013, 123, 1571–1579.
Mortimer P.S., Rockson S.G. New developments in clinical aspects of lymphatic disease. J. Clin. Investig. 2014, 124, 915–921.
Parkin D., Hakulinen T. Analysis of survival. In: Jensen O.M., Parkin D.M., MacLennan R., Muir C.S. and Skeet R.G. (eds) Cancer Registration, Principles and Methods. IARC Sci. Publ. №95. IARC Press, Lyon, 1991; pp 159–176.
Randolph G.J.; Miller N.E. Lymphatic transport of high-density lipoproteins and chylomicrons. J. Clin. Investig. 2014, 124, 929–935.
Sayegh H.E., Asdourian M.S., Swaroop M.N. e.a. Diagnostic methods, risk factors, prevention, and management of breast cancer-related lymphedema: Past, present, and future directions. Curr Breast Cancer Rep 2017;9:111-21.
Shah C., Vicini F.A. Breast cancer-related arm lymphedema: Incidence rates, diagnostic techniques, optimal management and risk reduction strategies. Int J Radiat Oncol Biol Phys 2011; 81: 907-14.
Siegel R., Naishadham D., Jemal A. Cancer Statistics, 2013 // CA Cancer J. Clin. - 2013; 63:11-30.
Small D.M., Bond M.G., Waugh D. e.a. Physicochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis. J. Clin. Investig. 1984, 73, 1590–1605.
Swaminathan R., Brenner H. Stastistical methods for cancer survival analysis // IARC Scientific Publications volume 162, ISBN 978-92-832-2162-3, Lyon, International Agency for Research on Cancer, 2011.
Shakhanova Sh. Sh., Rakhimov M. N. Aspects of sarcopenia syndrome in oncological practice: diagnosis and treatment (literature review) // Journal of Biomedicine and Practice. 2023, vol. 8, issue 3, pp. 406-417
Telinius N., Hjortdal V.E. Role of the lymphatic vasculature in cardiovascular medicine. Heart 2019, 105, 1777–1784.
Tsai R.J., Dennis L.K., Lynch C.F. e.a. The risk of developing arm lymphedema among breast cancer survivors: A meta-analysis of treatment factors. Ann Surg Oncol 2009;16:1959-72.
Vuorio T., Nurmi H., Moulton K. e.a. Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis. Arter. Thromb. Vasc. Biol. 2014, 34, 1162–1170.
Wang X., Rader D.J. Molecular regulation of macrophage reverse cholesterol transport. Curr. Opin. Cardiol. 2007, 22, 368–372.
Статья поступила в редакцию 30.10.2023; одобрена после рецензирования 21.12.2023; принята к публикации 25.12.2023.
The article was submitted 30.10.2023; approved after reviewing 21.12.2023; accepted for publication 25.12.2023.
Информация об авторах:
Джураев Миржалол Дехканович - д.м.н., профессор Республиканского специализированного научно-практического медицинского центра онкологии и радиологии Е-mail: Dr.djuraev@list.ru, ORCID:0000-0001-6988-6143
Узаков Сохиб Максудович – заведующий отделение онкомаммологии Самаркандского филиала Республиканского специализированного научно-практического медицинского центра онкологии и радиологии, сомостоятельный соискатель кафедры онкологии Самаркандского государственного медицинского университета, Самарканд, Узбекистан. Е-mail: soxib.uzokov@mail.ru, ORCID:0009-0005-9942-8000
Кутлумуратов Атабек Бекжанович - д.м.н., кафедры онкологии Самаркандского государственного медицинского университета. Е-mail: atabekb@yahoo.com, ORCID: 0009-0006-9783-1418
Каримова Мавлуда Нематовна - к.м.н., доцент кафедры онкологии Самаркандского государственного медицинского университета. Е-mail:mavluda.negmatovna@gmail.com, ORCID:0000-0003-2367-4318
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Джураев М.Д. - идеологическая концепция работы, написание текста; редактирование статьи; Узаков С.М. - сбор и анализ источников литературы, написание текста.
Кутлумуратов А.Б. - идеологическая концепция работы, написание текста; редактирование статьи;
Каримова М.Н. - сбор и анализ источников литературы, написание текста.
Information about the authors:
Mirzhalol Dehkanovich Juraev - MD, Professor of the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology E-mail: Dr.djuraev@list.ru , ORCID:0000-0001-6988-6143
Uzakov Sohib Maksudovich is the head of the Department of Oncomammology of the Samarkand branch of the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology, a wealthy candidate for the Department of Oncology of the Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: soxib.uzokov@mail.ru , ORCHID:0009-0005-9942-8000
Kutlumuratov Atabek Bekzhanovich - MD, Department of Oncology, Samarkand State Medical University. E-mail: atabekb@yahoo.com , ORCHID: 0009-0006-9783-1418
Mavluda Nematovna Karimova - PhD, Associate Professor of the Department of Oncology at Samarkand State Medical University. Е-mail:mavluda.negmatovna@gmail.com , ORCAD:0000-0003-2367-4318
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Juraev M.D. - ideological concept of work, text writing; article editing;
Uzakov S.M. - collection and analysis of literature sources, writing text.
Kutlumuratov A.B. - ideological concept of work, text writing; article editing;
Karimova M.N. - collection and analysis of literature sources, writing text.
