PATHOGENETIC ROLE OF VITAMIN D SYNTHESIS IN THE BODY ON SOMATIC AND DENTAL PATHOLOGY
Keywords:
vitamin D deficiency, osseointegration, dental implants, regeneration, periodontium, caries.Abstract
Vitamin D deficiency is usually caused by insufficient synthesis of the vitamin in the body due to insufficient sun exposure and/or a decrease in the synthetic properties of the skin with age. Persistent, severe vitamin D deficiency leads to bone demineralization with the clinical picture of rickets in children or osteomalacia in adults. In addition to the effects on bone, there is extensive experimental and epidemiological evidence that low levels of vitamin D are associated with numerous extraosseous effects. The role of vitamin D in the regulation of the expression of insulin receptors and insulin secretion has been experimentally proven, and a positive effect on the central nervous, endocrine and immune systems, as well as on cell differentiation and growth, has been established. The positive effects of vitamin D on the cardiovascular and respiratory systems remain largely controversial. A correlation between the severity of periodontitis and low levels of 25(OH)-vitamin D has been proven. This suggests a connection between low levels of vitamin D and the pathogenesis of periodontal diseases and its progression. D-hypovitaminosis can cause loss of dental implants.
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Статья поступила в редакцию 05.01.2024; одобрена после рецензирования 18.02.2024; принята к публикации 20.02.2024.
The article was submitted 05.01.2024; approved after reviewing 18.02.2024; accepted for publication 20.02.2024.
Информация об авторах:
Бекжанова Ольга Есеневна- д.м.н., профессор, Заведующая кафедрой факультетской терапевтической стоматологии, Ташкентский государственный стоматологический институт, Ташкент, Узбекистан. Е-mail: olga.bekjanova@gmail.com, https://orcid.org/ 0000-0002-1686-1820
Маннанов Жавлонбек Жамолиддинович- Старший преподаватель кафедры ирургической стоматологии и дентальной имплантологии, Ташкентский государственный стоматологический институт, Ташкент, Узбекистан. Е-mail: dr.javlonbek77@gmail.com, https://orcid.org/ 0009-0008-7395-8734
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Бекжанова О.Е. — идеологическая концепция работы, написание текста; редактирование статьи;
Мананов Ж.Ж. — сбор и анализ источников литературы, написание текста.
Information about the authors:
Bekjhanova Olga Esenovna - DSc, Professor, Head of the Department of Faculty Therapeutic Dentistry, Tashkent State Dental Institute, Tashkent, Uzbekistan. E-mail: olga.bekjanova@gmail.com , https://orcid.org / 0000-0002-1686-1820
Mannanov Javlonbek Jamoliddinovich Senior lecturer at the Department of Surgical Dentistry and Dental Implantology, Tashkent State Dental Institute, Tashkent, Uzbekistan. E-mail: dr.javlonbek77@gmail.com, https://orcid.org / 0009-0008-7395-8734
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Bekjanova OE — ideological concept of the work, writing the text; editing the article;
Mananov JJ — collection and analysis of literature sources, writing the text.
