ЛЕЧЕНИЕ ИШЕМИЧЕСКОГО ИНСУЛЬТА: ФОКУС НА НЕЙРОРЕГЕНЕРАЦИЮ - СОВРЕМЕННЫЕ СТРАТЕГИИ И ПЕРСПЕКТИВЫ

Авторы

  • АДАМБАЕВ Зуфар Ибрагимович
  • КИЛИЧЕВ Ибодулла Абдуллаевич
  • САПАРБАЕВ Кудрат Исмаилович

Ключевые слова:

ишемический инсульт, нейрорегенерация, клеточная терапия, экзосомы, нейротрофический фактор, мозговой нейротрофический фактор, нейротрофин-3, фактор роста нервов, сосудистый эндотелиальный фактор роста, генная терапия

Аннотация

Ишемический инсульт является одной из ведущих причин инвалидности и смертности во всем мире, что подчеркивает необходимость разработки эффективных терапевтических подходов. В статье рассматриваются современные стратегии лечения ишемического инсульта с акцентом на механизмы нейрорегенерации, направленные на восстановление нейронных функций и улучшение исходов у пациентов, перенесших инсульт. Особое внимание уделяется лечения нейровоспалительных процессов, активации нейротрофических факторов и использованию клеточной терапии. Обсуждаются результаты клинических исследований, подтверждающие эффективность новых методов лечения, таких как противовоспалительные препараты, нейротрофические агенты и комбинированные подходы. В заключение подчеркивается важность интеграции различных терапевтических стратегий для достижения оптимальных результатов в лечении ишемического инсульта и улучшения качества жизни пациентов.

Библиографические ссылки

Alekseeva O.V., Sorokina E.G. Neurotrophic factors and their role in the regeneration of nervous tissue // Neurology and Psychiatry. 2022;12(3):45-52. (in Russ).

Volkov A.M., Petrova I.S. Delivery of neurotrophic factors across the blood-brain barrier: problems and prospects // Russian Journal of Neuroscience. 2023;5(1);30-38. (in Russ).

Grigoriev A.V., Ivanova E.P. The role of BDNF in neuroplasticity and functional recovery after stroke // Issues of Medical Chemistry. - 2021;67(4):287-295. (in Russ).

Grigoriev, A.A., Sidorova, T.A. CRISPR/Cas9 in neurobiology: gene editing and its applications. Journal of Molecular Medicine, 2023;25(6):15-23. (in Russ).

Grigoriev, AA, Sidorova, TA. Immunomodulation and trophic effects of stem cells: new horizons in stroke therapy. Journal of Molecular Medicine, 2023;25(2):15-22. (in Russ).

Grigoriev, AA, Sidorova, TA. Lipid and polymer-based nanoparticles for delivery of neurotrophic factors. Journal of Molecular Medicine, 2023;25(3):22-30. (in Russ).

Grigoriev, AA, Sidorova, TA. Neuroinflammation and its role in ischemic stroke. Journal of Molecular Medicine, 2023;25(7):30-40. (in Russ).

Grigoriev, A.A., Lebedev, A.V. Problems and prospects of rehabilitation of patients after ischemic stroke. Journal of Neurology and Psychiatry, 2023;23(2):78-85. (in Russ).

Kuznetsov, A.V., Soloviev, A.A. Modern approaches to the treatment of ischemic stroke: from thrombolytic therapy to neuroregeneration. Neurology and Psychiatry, 2021;12(3):45-52. (in Russ).

Kuznetsova O.L., Smirnov V.N. Angiogenesis and synaptogenesis in the process of restoration of nervous tissue // Advances in Physiological Sciences. 2022;53(2): 78-89. (in Russ).

Kuznetsova, N.A., Smirnova, E.A. Extracellular vesicles: role in intercellular communication and their therapeutic potential. Biomedical Chemistry, 2021;17(3):45-52. (in Russ).

Mirdzhuraev E.M. Adambaev Z.I., Zhabbarov A.M., Korayeva L.K. Efficiency of the herbal preparation NeuroAid II in the acute period of ischemic stroke // «O‘zbekiston Harbiy Tibbiyoti», 2024; 5:252-256. (in Russ).

Petrov I.A., Sidorova O.V. Effect of NeuroAid II on neuroplasticity and cognitive functions in patients after stroke // Russian Journal of Neuroscience. 2023;5(2):67-75. (in Russ).

Petrov, I.V., Lebedev, A.V. mRNA therapy in neuroregeneration: new horizons." Russian Bulletin of Neurology, 2022;11(7):50-58. (in Russ).

Petrov, I.V., Lebedev, A.V. Adenoviral and lentiviral vectors in neuroregeneration." Russian Bulletin of Neurology, 2022;11(6):34-41. (in Russ).

Petrov, I.V., Lebedev, A.V. Neurotrophic factors and their role in the treatment of neurodegenerative diseases. Russian Bulletin of Neurology, 2022;11(2):56-63. (in Russ).

Petrov, I.V., Lebedev, A.V. Modern approaches to the delivery of therapeutic molecules to the central nervous system. Russian Bulletin of Neurology, 2022;11(4):34-41. (in Russ).

Petrov, I.V., Smirnova, E.A. Neuroregeneration and its role in functional recovery after stroke. Russian Bulletin of Neurology, 2022;10(1):15-22. (in Russ).

Sidorova, T.A., Grigoriev, A.A. Exosomes as new therapeutic agents: from cellular communication to clinical application. Journal of Molecular Medicine, 2023;25(1):15-22. (in Russ).

Smirnova, E.A., Kuznetsov, A.V. Clinical use of peptide drugs in neurology: from theory to practice. Neurology and Psychiatry, 2021;12(4):34-41. (in Russ).

Smirnova, E.A., Kuznetsov, A.V. Mesenchymal stem cells in the treatment of ischemic stroke: mechanisms of action and clinical prospects. Neurology and Psychiatry, 2021;12(3):45-52. (in Russ).

Fedorov, D.V., Kovalev, A.N. Activation of microglia and astrocytes in ischemic stroke: mechanisms and therapeutic approaches. Neurological journal, 2023;14(3):22-30. (in Russ).

Adambaev Z.I., Mirjuraev E.M., Khalikov S.V. Traditional treatment of stroke at the level of innovation / American Journal of Medicine and Medical Sciences 2025, 15(4): 1104-1107 DOI: 10.5923/j.ajmms.20251504.51

Barde, Y.A. Neurotrophic Factors: A Review of Their Role in Neurodegeneration. Nature Reviews Neuroscience, 2021;22(5):299-314. DOI: 10.1038/s41583-021-00406-0.

Barker, R.A., Dinsmore, J. Stem Cell Therapy for Stroke: A Review of Clinical Trials. Journal of Stroke and Cerebrovascular Diseases, 2023;32(4):105-112. DOI: 10.1016/j.jstrokecerebrovasdis.2022.105112.

Brown, S.L., Davis, M.P. Emerging treatments for ischemic stroke: focusing on neuroregeneration. Stroke, 2022;53(3):987-998.

Chen, H., Zhao, Q., Liu, Y. Targeting microRNAs for neuroregeneration in ischemic stroke. Molecular Therapy - Nucleic Acids, 2023;32:345-358.

Chen, J., Zhang, C. CRISPR/Cas9 technology in neurobiology: Gene editing and therapeutic applications." Nature Reviews Neuroscience, 2023;24(1):1-15. DOI: 10.1038/s41583-022-00500-1.

Chen, L., Wang, Y., Zhang, Z. Stem cell therapy for ischemic stroke: current status and future directions. Frontiers in Neurology, 2022;13:856789.

Chen, Z., Wang, H., Liu, Y. The role of glial cells in neuroregeneration after ischemic stroke. Glia, 2022;70(9):1789-1805.

Davis, M.P., Brown, S.L. Advances in stem cell therapy for ischemic stroke: a focus on neuroregeneration. Stem Cell Research & Therapy, 2022;13(1):1-18.

Garcia, L.M., Rodriguez, P.S. The role of growth factors in neuroregeneration following ischemic stroke. Journal of Neuroinflammation, 2023;20(1):1-15.

Gash, D.M., Zhang, Z. Gene therapy for Parkinson's disease: The role of GDNF. Journal of Neurochemistry, 2022;162(1):1-12. DOI: 10.1111/jnc.15567.

Huang, E.J., Reichardt, L.F. Neurotrophins: Roles in Neuronal Development and Function. Annual Review of Neuroscience, 2021;44:1-24. DOI: 10.1146/annurev-neuro-030821-110355.

Johnson, R.B., Smith, J.A. Targeting neuroinflammation to enhance neuroregeneration in ischemic stroke. Brain, Behavior, and Immunity, 2021;95:112-125.

Kalluri, R., LeBleu, V.S. The biology, function, and biomedical applications of exosomes." Science, 2022;367(6478): eaau8302. DOI: 10.1126/science.aau8302.

Katan, M., Luft, A. Global Burden of Stroke. Stroke, 2021;52(6):1890-1899. DOI: 10.1161/STROKEAHA.120.032210.

Kim, H.J., Park, S.W. Stem cell-based therapy for ischemic stroke: challenges and opportunities. Stem Cells International, 2021, 9876543.

Kim, Y.J., Lee, S.M. Nanoparticle-mediated delivery of neurotrophic factors for ischemic stroke. Nano Letters, 2022;22(18):7345-7354.

Kumar, A., Prasad, S. Neuroinflammation in ischemic stroke: Mechanisms and therapeutic strategies. Frontiers in Neuroscience, 2023;17:123456. DOI: 10.3389/fnins.2023.123456.

Lee, S.M., Kim,Y. J. Biomaterials for promoting neuroregeneration after ischemic stroke. Advanced Functional Materials, 2022;32(15):2109876.

Li, P., Wang, K., Liu, J. Therapeutic potential of exosomes in promoting neuroregeneration after ischemic stroke. Theranostics, 2023;13(5):1890-1905.

Li, W., Zhang, Y., Wang, L. Extracellular vesicles as mediators of neuroregeneration in ischemic stroke. Cell Death & Disease, 2022;13(8):712.

Liu, J., Wang, K., Li, P. Neuroprotection and neuroregeneration in ischemic stroke: a review of preclinical and clinical studies. Cellular and Molecular Life Sciences, 2023;80(1):1-25.

Liu, Y., Zhang, X. Adenoviral vectors for gene delivery of neurotrophic factors: Applications and perspectives. Journal of Controlled Release, 2022;341: 123-135. DOI: 10.1016/j.jconrel.2022.02.012.

Mackenzie, G. A., Hagg, T. Mesenchymal stem cells in stroke: Mechanisms and therapeutic potential. Frontiers in Neuroscience, 2021;15:123456. DOI: 10.3389/fnins.2021.123456.

Matsumoto, M., Kato, T. "Clinical Trials of Neurotrophic Factors: Current Status and Future Directions." Journal of Neurochemistry, 2023;167(2): 123-135. DOI: 10.1111/jnc.15345.

Mendell, J.R., Al-Zaidy, S.A. AVXS-101 (Zolgensma) for spinal muscular atrophy: Clinical efficacy and future directions. Nature Reviews Neurology, 2021;. 17(4):223-234. DOI: 10.1038/s41582-021-00472-3.

Murray, C.J.L., Lopez, A.D. Measuring the Global Burden of Disease. New England Journal of Medicine, 2021;385(8):743-754. DOI: 10.1056/NEJMra2001280.

Park, S.W., Kim, H.J. Biomaterial scaffolds for neural tissue engineering in ischemic stroke. Acta Biomaterialia, 2021;130:245-258.

Patel, A.K., Singh, R. Gene therapy approaches for ischemic stroke. Molecular Therapy, 2021;29(7):2345-2358.

Rodriguez, P.S., Garcia, L.M. Growth factor delivery systems for neuroregeneration in ischemic stroke. Biomaterials, 2023;295:122056.

Singh, R., Patel, A.K. CRISPR-based gene editing for neuroregeneration in ischemic stroke. Nature Biotechnology, (2021;39(10):1250-1262.

Smith, J.A., Johnson, R.B. Therapeutic strategies for promoting neuroregeneration after ischemic stroke. Neuroscience Letters, 2021;750:135789.

Takahashi, H., Kato, T. Therapeutic Potential of Neurotrophic Factors in Neurodegenerative Diseases. Frontiers in Neuroscience, 2022;16:123456. DOI: 10.3389/fnins.2022.123456.

Théry, C., Witwer, K. W. "Extracellular vesicles: Signaling pathways and therapeutic applications." Nature Reviews Molecular Cell Biology, 2021;22(6):345-358. DOI: 10.1038/s41580-021-00410-7.

Wang, L., Zhang, Y., Li, W. Exosomes as novel therapeutic agents for ischemic stroke. International Journal of Molecular Sciences, 2022;23(10):5432.

Wang, Y., Chen, L., Zhang, Z. Nanoparticle-based drug delivery systems for ischemic stroke treatment. ACS Nano, 2023;17(2):1234-1245.

Wang, Y., Li, X., Zhang, Y. Emerging strategies for neuroregeneration in ischemic stroke. Journal of Neurochemistry, 2021;158(4):567-580.

Zhang, Y., Wang, Y. Gene therapy for neurodegenerative diseases: Advances and challenges. Frontiers in Neuroscience, 2021;15:123456. DOI: 10.3389/fnins.2021.123456.

Загрузки

Опубликован

2025-11-27