EPIDEMIOLOGICAL ASPECTS OF DEVELOPMENTAL DISORDERS IN CHILDREN BORN FROM CONSANGUINEOUS MARRIAGES
Keywords:
consanguineous marriages, inbreeding, epidemiology, diagnostics, family, children, hereditary diseasesAbstract
The article examines the epidemiological aspects of developmental disorders in children born from consanguineous marriages, with an emphasis on genetic risks and the relevance of the problem in Uzbekistan and worldwide. Particular attention is paid to the priority of children’s health as the foundation of the nation’s future. The paper highlights the progress of Uzbek medicine after independence, including the introduction of modern technologies and state programs aimed at early detection of hereditary diseases. Despite certain social and economic advantages of consanguineous unions, such as strengthening family ties and preserving property, they are associated with a significant medical and social burden. The necessity of further research, preventive strategies, and early diagnostic measures to protect the health of future generations is emphasized.
References
Vogel F, Motulsky A. Human Genetics. Problems and Approaches.Springer Verlag, Berlin—Heidelberg—New York; 1979. https://doi.org/10.1002/bimj.4710230321
Ochilzoda A.A., Karimov T.M., Karimov H.H., Jalilov D.A., Sharipov S.E. Hearing Condition in Children with Deafness Based on Relational Marriage. Bulletin of the Kazakh National Medical University. 2016; 4:124-129. (in Russ).
Murzakhanov Yu.I. Family and Marriage Institute among the Jews of the Nalchik Mountains: Traditions and Modernity. Society: philosophy, history, culture.2016;4:66-68. (in Russ).
Magomedova A.Sh., Omarov S.M. Perinatal aspects of blood marriage. Archives of Internal Medicine.2016;6(1):15-16. (in Russ).
Malikova D.B., Kurbanov D.D. Characteristics of clinical indicators in women with infertility living in the Andijan region. Journal of Theoretical and Clinical Medicine.2014; 4:92-95. (in Russ).
Koc I, Ali Eryurt M. The causal relationship between consanguineous marriages and infant mortality in Turkey. Journal of Biosocial Science. 2017;49(4):536-555.https://doi.org/10.1017/S002193201600033X
Maghsoudlou S, Cnattingius S, Aarabi M, Montgomery SM, Semnani S, Stephansson O, Wikstrom AK, Bahmanyar S. Consanguineous marriage, prepregnancy maternal characteristics and stillbirthrisk: a population-based case—control study. Acta Obstetricia et Gynecologica Scandinavica. 2015;94(10):1095-1101.https://doi.org/10.1111/aogs.12699
Fareed M, Kaisar Ahmad M, Azeem Anwar M, Afzal M. Impact of consanguineous marriages and degrees of inbreeding on fertility, child mortality, secondary sex ratio, selection intensity, and genetic load: a cross-sectional study from Northern India. Pediatric Research. 2017;81(1-1):18-26. https://doi.org/10.1038/pr.2016.177
Khoury SA, Massad DF. Consanguinity, fertility, reproductive wastage, infant mortality and congenital malformations in Jordan. Saudi Medical Journal. 2000;21(2):150-154.https://doi.org/10.1002/ajmg.1320430502
vanov A.G. Medical and social approaches to improving the reproductive potential of modern youth. Russian Medical and Biological Herald named after Acad. I.P. Pavlov.2004;3-4:105-107. (in Russ).
Stoll C, Alembik Y, Dott B, Feingold J. Parental consanguinity as acause of increased incidence of birth defects in a study of 131,760 consecutive births. American Journal of Medical Genetics. 1994;49(1):114-117. https://doi.org/10.1002/ajmg.1320490123.
Jaouad IC. Elalaoui SC, Sbiti A, Elkerh F, Belmahi L, Sefiani A. Consanguineous marriages in Morocco and the consequence for the incidence of autosomal recessive disorders. Journal of Biosocial Science. 2009;41(5):575-581.https://doi.org/10.1017/S0021932009003393
Tunçbílek E., Koç I. Consanguineous marriage in Turkey and its impact on fertility and mortality // Annals of Human Genetics. 1994. Vol. 58, №4. P. 321-329. doi:10.1111/j.1469-1809.1994.tb00729.x
Kaplan S., Pinar G., Kaplan B., et al. The prevalence of consanguineous marriages and affecting factors in Turkey: a national survey // Journal of Biosocial Sci-ence. 2016. Vol. 48, №5. P. 616-630. doi:10.1017/ s0021932016000055
Yamamah G., Abdel-Raouf E.M., Talaat A., et al. Prevalence of consanguineous marriages in South Si-nai, Egypt // Journal of Biosocial Science. 2013. Vol. 45, №1. P. 31-39. doi:10.1017/s002193201200020x
Hosseini-Chavoshi M., Abbasi-Shavazi M.J., Bittles A.H. Consanguineous Marriage, Reproductive Behavior and Postnatal Mortality in Contemporary Iran // Human Heredity. 2014. Vol. 77, №1-4. P. 16-25. doi:10.1159/000358403
Al-Arrayed S., Hamamy H. The changing profile of consanguinity rates in Bahrain, 1990-2009 // Journal of Biosocial Science. 2012. Vol. 44, №3. P. 313-319. doi:10.1017/s0021932011000666
Manglos-Weber N, Weinreb A. Own-Choice Marriage and Fertility in Turkey. Journal of Marriage and Family. 2016;79(2):372-389. https://doi.org/10.1111/jomf.12348.
Zakzouk S. Consanguinity and hearing impairment in developing countries: a custom to be discouraged. The Journal of Laryngology and Otology. 2002;116(10):811-816. https://doi.org/10.1258/00222150260293628
Ochilzoda A. A., Rahmonov Z. P., Ochilzoda S. U. Effectiveness of surdopedagogical classes in ear prosthetics in young children with hearing loss due to kinship marriage // Healthcare of Tajikistan.2002. № 3. С. 123–124. (in Russ).
Nouri N-s., Nouri N-h., Tirgar S., et al. Consanguineous marriages in the genetic counseling centers of Isfahan and the ethical issues of clinical consultations // Journal of Medical Ethics and History of Medicine. 2017. Vol. 10. P. 1-10.
Gunaid A.A., Hummad N.A., Tamim K.A. Consanguineous marriage in the capital city Sana’a, Yemen // Journal of Biosocial Science. 2004. Vol. 36, №1. P. 111-121. doi:10.1017/s0021932003006138.
Tadmouri GO, Nair P, Obeid T, Al Ali MT, Al Khaja N, Hamamy HA. Consanguinity and reproductive health among Arabs. Reproductive Health. 2009;6:17. https://doi.org/10.1186/1742-4755-6-17.
Barbour B., Salameh P. Consanguinity in Lebanon: prevalence, distribution and determinants // Journal of Biosocial Science. 2009. Vol. 41, №4. P. 505-517. doi:10.1017/s0021932009003290
Mahmadjonov D.M., Sultonov Sh.R., Sattorov A.M. Diagnosis of complicated nephrolithiasis in children. Russian Bulletin of Pediatric Surgery, Anesthesiology and Reanimatology.2016; 6(1):47-50. (in Russ).
Kuzibayeva N.K. Risk factors for the formation of congenital heart defects in children in Tajikistan. Avicenna Herald.2013;4:99-103. (in Russ).
Saatova G.M., Furtikova A.B., Zhanturaeva B.T. Risk of congenital heart defects in children in Kyrgyzstan.2016;10:53-56. (in Russ).
Khodjamurodova D.A. The structure of causes and diagnosis of infertile marriage in the population of the Republic of Tajikistan. Avicenna Herald. 2010;4:71-77. (in Russ).
