ИЗУЧЕНИЕ РАСПРОСТРАНЕННОСТИ АЛЛЕЛЕЙ И ГЕНОТИПОВ ДВУХ ПОЛИМОРФНЫХ МАРКЕРОВ ГЕНА CYP 2С9 И CYP 2С19
Ключевые слова:
полиморфный маркер гена CYP 2С9, полиморфный маркер гена CYP 2С19, генетика, волонтеры, узбекская национальностьАннотация
Наиболее значимыми, в клиническом отношении, полиморфными маркерами гена CYP2C9 являются аминокислотные замены CYP2C9*2 (замена в 144 положении полипептидной цепи, приводящая к замещению аминокислоты аргинина на цистеин; 144Arg) и CYP2C9*3 (замена в 359 положения полипептидной цепи, приводящая к замещению аминокислоты изолейцина на лейцин; 359Leu). Генетический полиморфизм СУР2С19 имеет выраженные межиндивидуальные различия. Значимость генетического полиморфизма определяют при уровне встречаемости вариантных аллелей более 1% в популяции.
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