PHARMACOLOGICAL ASSESSMENT OF EFFECT OF NEW DRUG DECOGLITZ ON NERVOUS AND CARDIOVASCULAR SYSTEMS
Keywords:
drugAbstract
Objective: study of the effect of the new anticancer drug on the nervous and cardiovascular systems of experimental animals
Methods: The study used 120 mice and 18 rabbits, used etaminal sodium and chloral hydrate to study hypnotic effects, as well as corazole and strychnine to study convulsive effects, decoglycs were administered orally at doses of 26 and 52 mg/kg. In the study of the effect on blood pressure level, the substance decoglycs were orally administered to rabbits at doses of 5 and 10 mg/kg.
Results: the test substance decoglytz, when administered at doses of 26 and 52 mg/kg, is permissible when used together with sedatives and sleeping pills, does not cause antagonistic action to the agents of this group. Similarly, with convulsive neurotransmitters, a dose of 26 mg/kg led to a reduction in seizures by 10-20%, Decoglitz at a dose of 56 mg/kg did not affect the excitatory processes of the central nervous system. Studies of the drug decoglytz on cardiovascular indicators showed that the use of the drug does not cause even a minor
Conclusion: All the above data make it possible to conclude that the drug does not have a toxic effect on the nervous and cardiovascular systems of animals.
References
Еникеева З.М., Ибрагимов А.А. Новый класс цитостатиков со стимуляцией колониеобразующих единиц на селезенке (КОЕс). Ташкент, из-во «Fan va texnologiya», 2016г, 173с
Еникеева З.М., Агзамова Н.А., Ибрагимов А.А., Саидходжаева С.С., Холтураева Н.Р., Хасанова Д., Туйчиев О.Д., Умаров М.Х. , Зиявиденова С.С. Эффективность препарата дэкоглица на крысах с опухолью яичников и его влияние иммунитет. Вестник медицинской академии, 2021,№3 с. 77-80
Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ». Под общей ред. Миронова. Москва, 2012
Толстиков Г. А., Балтика Л. А., Э. Э. Шульц, А. Г. Покровский. Глицирризиновая кислота // Биоорганическая Химия,1997, том 23, № 9, с. 691-709
Яковишин Л. А . Молекулярные комплексы тритерпеновых гликозидов с биологически активными веществами: получение, химико-фармацевтические свойства и биологическая активность. Автореферат диссертации доктора химических наук, Казань, 2018, 35с
Holikov T.K ., Gafur-Akhunov M.A., Goyibova S., Yenikeeva Z.M.«New antitumour preparation- decocini-for the treatment of skin cancer, and igreasing effect of irradiation to the tumour as well», Journal Avicena- Friburg - Germany, Heft 2, 2011, s. 32-37
Enikeeva Z. M. Ibragimov A. A., Agzamova N.A., Vypova N.L., Saidhodjaeva S.S., Kholturaeva N. R., Abdirova A.Ch., Tuy¬chiev O.D., Polatova J. Sh., Kadirova D. A., Salihov F. S. Study of the Antitumor Activity of the Drug Dekoglitz on Two Tumors and Some Aspects of Its Mechanism of Action . Journal of Oncology Research, Volume 03 | Issue 01 | January 2021, р.11-16
Enikeeva Z. M., Agzamova N. A., Ibragimov A. A., Ziyavidenova S. S., Kholturaeva N. R., Alimkhodjaeva L. T.The Effect of the New Drug Decoglitz on Tumors of Mice and Rats with Oral and Intraperitoneal Use and Its Effect on Immunity. Research In Cancer and Tumor 2021, 9(2): 23-27
Ziyavidenova S. S., Vypova N. L., Enikeeva Z. M., Agzamova N. A.,Nishanov D. A., Madaliev A. A., Alimkhodjaeva L. T. Study of the Toxic Features of the Antitumor Drug Decoglitz. American Journal of Medicine and Medical Sciences 2021, 11(10): 705-710
