KO’P O’CHOQLI SUT BEZI SARATONIDA ASOSIY VA IKKILAMCHI O’SMA TUGUNIDA GORMON RETSEPTORLARI HOLATIDAGI FARQLAR
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multisentrik, ko’p o’choqli, sut bezi saratoni, gistologik tekshiruv, immunogistokimyo, gormon retseptorlari##article.abstract##
Tadqiqotning maqsadi: Ko‘krak bezi saratoni (KBS) bilan og‘rigan bemorlarda katta va kichik o‘smalarning molekulyar-biologik xususiyatlarini tahlil qilishdan iborat. Material va metod: Respublika ixtisoslashtirilgan onkologiya va radiologiya ilmiy-amaliy markazi va uning filiallarida 2018-2023-yillar davomida davolangan 133 nafar bemor ma’lumotlari retrospektiv tahlil qilingan. Gistologik, immunogistokimyoviy tahlillar o’tkazilgan. Natijalar: Asosiy va ikkinchi o‘sma tugunlarida IGH tahlili o’tkazilganda, asosiy tugunda ER va PR retseptorlari aniqlanmagan taqdirda, ikkinchi tugunda gormon retseptorlarining musbat holati aniqlandi. (p-0.05) Xulosa: Asosiy tugunda gormon retseptorlari manfiy bo’lgan taqdirda, ikkinchi tugunda IGH tahlili o’tkazish tavsiya etiladi. Bu davolash dasturlariga gormonoterapiya qo’shish mumkinligini belgilab beruvchi omil hisoblanadi.
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