HOMILA ICHI INFEKTSIYASIDA IMMUN KOMPLEKSLARINING PATOGENETIK QIYMATLARI
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aylanma immun komplekslar, komplement, immunoglobulinlar, yangi tug'ilgan chaqaloqlar##article.abstract##
Ushbu tadqiqotda neonatal patologiyasi bo'lgan 140 nafar yangi tug'ilgan chaqaloqni qon zardobidagi aylanma immun komplekslar (AIK) va immunoglobulinlarning (A, M, G) uchta sinfini tekshirish natijalari keltirilgan. AIKning eng yuqori ko'rsatkichlari homila ichi pnevmoniyasi (HIP) bo'lgan yangi tug'ilgan chaqaloqlarda qayd etilgan bo’lib, bu 153,4± 0,93shart. birliklarga teng. AIKning xuddi shu ko'rsatkichlari yangi tug'ilgan chaqaloqlarning neonatal pnevmoniya (NP) va (157,3± 0,
91shart. ) yiringli-yallig'lanish kasalliklarida (YYK) (141,2± 0,84) ham ko’rsatilgan. AIKning yuqori ko'rsatkichlari yangi tug'ilgan chaqaloqlarning homila ichi davrida ularning organizmiga kirgan antigenlarning ko’pligini isbotlaydi. AIKning yuqori darajasiga teskari proportsional ravishda komplement kontsentratsiyasi (CH50) kamayadi (45,1birlik - HIP, 44,3 birlik – NP, 41,2 birlik – YYK,
normal – 50,4birlik), bu AIKning shakllanishida antigen – antitelo reaktsiyasida komplementni iste'mol qilinishi bilan izohlanishi mumkin. Yangi tug'ilgan chaqaloqlar neonatal pnevmoniyasi (5,0±0,32) va yiringli-yallig'lanish kasalliklarida (3,8 ± 0,32) Ig G ning me'yorga nisbatan past ko'rsatkichlari, hamda homila ichi pnevmoniyasida (5,0 ± 0,34) Ig G ning yuqori ko’rsatkichlari, Ig
G ning yo’ldosh orqali o’tishiga va homila ichi infektsiyalanishida yetakchi omil ekanligini ko’rsatadi.
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