QAYTALANUVCHI AFTOZ STOMATITNI MAHALLIY DAVOLASHDA ZAMONAVIY QARASHLAR
##article.subject##:
qaytalanuvchi aftoz stomatit, mahalliy davolash, fagoterapiya, bakteriofag, epitelizatsiya.##article.abstract##
Qaytalanuvchi aftoz stomatit (QAS) yuqori tarqalganligi va bemorlarning hayot sifatiga sezilarli ta’siri tufayli stomatologiyaning dolzarb muammolaridan biri bo‘lib qolmoqda. Tadqiqotning maqsadi. QASda mahalliy fagoterapiyaning klinik samaradorligini baholash. Material va metodlar. Tadqiqotga kasallikning o‘rtacha og‘irlikdagi kechishi bilan og‘rigan 23 nafar bemor kiritilgan bo‘lib, ular asosiy guruh (bakteriofag bilan davolash) va taqqoslash guruhiga (standart terapiya) bo‘lindi. Og‘riq sindromi dinamikasi, epitelizatsiya muddatlari va qaytalanish chastotasi baholandi. Natijalar. Asosiy guruhdagi bemorlarda og‘riqning ertaroq pasayishi (2-3 kunga), epitelizatsiyaning tezlashishi (taqqoslash guruhida o‘rtacha 4,1 ± 0,6 kun, 6,3 ± 0,8 kunga qarshi, p<0,05) va 6 oylik kuzatuv davomida retsidivlarning kamroq chastotasi (25% ga qarshi 58,3%) kuzatildi. Xulosalar. Olingan natijalar bakteriofagning yuqori klinik samaradorligidan dalolat beradi va uning QASda mahalliy davolash vositasi sifatida istiqbolliligini tasdiqlaydi.
Библиографические ссылки
Abed J., et al. Phage therapy in inflammatory disorders. World J Gastroenterol. 2017;23(34):6530–6541.
Albanidou-Farmaki E., et al. Psychosocial stress as a trigger of recurrent aphthous stomatitis. Oral Dis. 2008;14:247–252.
Altenburg A., et al. The treatment of recurrent aphthous stomatitis. Dtsch Arztebl Int. 2014;111(40):665–673.
Chiang C.P., et al. Recurrent aphthous stomatitis – etiology, serum autoantibodies, anemia, hematinic deficiencies, and management. J Formos Med Assoc. 2019;118(9):1279–1289.
Kamilov Kh.Sh., Shukurova G.S. Index of severity in chronic recurrent aphthous stomatitis. Stomatology. 2013;4:45–48. (in Russ)
Natah S.S., et al. Recurrent aphthous ulcers today: a review of the growing knowledge. Int J Oral Maxillofac Surg. 2004;33:221–234.
Preeti L., Magesh K.T., Rajkumar K., Karthik R. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 2011;15(3):252–256.
Scully C., Porter S. Recurrent aphthous stomatitis: current concepts of etiology, pathogenesis and management. J Oral Pathol Med. 2008; 37 (5):283–293.
Sun A., et al. Genetics and recurrent aphthous stomatitis: a review. J Oral Pathol Med. 2015;44 (7):475–482.
Rizaev JA, Shodmonov AA Optimizing the Surgical Phase of Dental Implants Optimization of the Surgical Phase of Dental Implantation Based on Computer Modeling //Eurasian Medical Research Periodical. – 2022. – T. 12. – S. 84-87.
Jasim, S. A., Gupta, J., Uthirapathy, S., R., R., Kazmi, S. W., & Rizaev, J. A. (2025). A comprehensive review of immunotherapy in gastrointestinal tumors with a focus on the role of combination therapy with PARP inhibitors. Naunyn-Schmiedeberg’s Archives of Pharmacology, 1–17.
Shakhanova, S. S., & Rakhimov, N. M. (2025). The role of troponin and IL-6 in immunological assessment of sarcopenia in oncological patients. Central Asian Journal of Medical and Natural Science, 6(3), 1229–1233.
