ПАРКИНСОН КАСАЛЛИГИДА ЭНДОКРИН ВА МИКРОБИОТА ОМИЛЛАРИНИНГ КАСАЛЛИК ОҒИРЛИГИ БИЛАН ЎЗАРО БОҒЛИҚЛИГИНИ ТАҲЛИЛ ҚИЛИШ
##article.subject##:
тиреоид гомеостаз, микробиота, имидазолпропионат (ImP).##article.abstract##
Мақсад: Паркинсон касаллигида гипертиреоз ва ичак микробиотаси ўзгаришларининг клиник аҳамиятини баҳолаш ва уларнинг касаллик оғирлиги билан боғлиқлигини аниқлаш. Методлар: Тадқиқотни бажаришда клиник-неврологик, (лаборатор-ТТГ,ТГ,Т3,Т4) микробиота таҳлили (метагеномик ПЦР-Streptococcus mutans, Bacteroides, Firmicutes) микроблар сонини аниқлаш, нейровизуализацион, (Хен-Яр, UPDRS) шкаласи, MMSE (Mini- Mental State Examination) тест, кўп омилли статистик таҳлил усуллардан фойдаланилган. Натижалар: Олинган натижалар гипертиреознинг тиреоид гормонлари орқали дофамин метаболизмига таъсир этиб, ПК патогенезини тезлаштириши мумкинлигини кўрсатди. Ичак микробиотасининг бузилиши, айниқса Streptococcus mutans кўпайиши, ImP орқали митохондриал стресс ва α-синуклеин агрегациясини кучайтиради. Ичак микробиотасидаги Streptococcus mutans кўпайиши ImP даражасини оширади ва дофаминергик нейронларга токсик таъсир кўрсатади. ПК патогенезини баҳолашда эндокрин ва микробиота кўрсаткичларини биргаликда таҳлил қилиш муҳим. Хулоса: Шундай қилиб, I назорат гуруҳда
ПК ва гипотериоз билан оғриган беморларда, II-қиёсий гуруҳ фақат ПК билан касалланган беморларга нисбатан ПК натижасида юзага келган симптомлардан тремор кучайиши ва когнитив фаолиятнинг бузулишининг прогрессив хусусияти билан намоён бўлди. Касалликнинг турли босқичларида ҳаракат ва когнитив бузилишларни динамикада баҳолаш, ўз вақтида ҳаракат бузилишларни эндокринолог ва невролог билан коррекция қилиш ва касалликни стабил ушлаб туриш имконини бериш мумкин. ПК билан касалланган беморларда микробиота кўрсаткичларини, гипотиреоз ва гипертериознинг мавжудлигини текшириш ва аксинча, гипотиреоз хамда, гипертериоз билан касалланганларда ПК текшириш керак.
Библиографические ссылки
Abdullaeva N. N. et al. Pain syndrome in Parkinson's disease // Journal of Neurology and Neurosurgical Research. - 2022. - Vol. 3. - No. 6. (in Uzb).
Artemyev D. V., Age-related aspects of Parkinson's disease. Guide for doctors based on the materials of the II National Congress, M-2022.(in Russ).
Aliev M.A., Mamadaliev A.M., Mamadalieva S.A. Research of essential elements composition in the cerebrospinal fluid in patients with outcomes of traumatic brain injury // International scientific journal, 2020. No. 9. P. (in Uzb).
Aliev M.A., Mamadaliev A.M., Mamadalieva S.A. Research of essential elements composition in the cerebrospinal fluid in patients with outcomes of traumatic brain injury // International scientific journal, 2021. № 9. С. (in Uzb).
Artemyev D. V., Age-related aspects of Parkinson's disease. Guide for doctors based on the materials of the II National Congress, M-2022.(in Russ).
Антонова К.В. Психические расстройства в клинике эндокринных заболеваний. РМЖ.
; 26: 1889. (in Russ).
Bridwell R., Willis G., Gottlieb M., et al. Decompensated hypothyroidism: a review for the emergency clinician. Am. J. Emerg. Med. 2023; 39: 207–212.
Boyzhuraev O. N., Toshtemirov Sh. I., Djurabekova A. T. Results of treatment of patients with vascular parkinsonism with the drug mydocalm // Editor-in-chief: Sukiasyan A. A., PhD, Senior Lecturer, 2025. P. 184. (in Uzb).
Burieva D. M., Khakimova S. Z., Djurabekova A. T. Comparative study of the function of maintaining vertical posture in healthy individuals and patients with parkinsonism // Innovative science, 2023. No. 6-2. (in Uzb).
Bloem BR, Okun MS, Klein C. Parkinson’s disease. Lancet. 2021;397(10291):2284–2303.
Van Boxtel M., Menheere P., Bekers O., et al. Thyroid function, depressed mood, and cognitive performance in older individuals: the Maastricht Aging Study. Psychoneuroendocrinology. 2020; 29 (7): 891–898.
Eshimova Sh.K., Khakimova S.Z., Dzhurabekova A.T. Evaluation of the effectiveness of antitremor drugs in patients with essential tremor // Innovative Science, 2021. No. 1-3 (13). (in Uzb).
Grachev I.S., Fedorova N.V. Drug-induced dyskinesias in Parkinson's disease: classification, impact on quality of life and approaches to treatment. Guide for physicians based on the materials of the 1st National Congress, M-2023.-P. 88-9188.(in Russ).
Kopishinskaya S.V., Gustov A.V., Makushina E.V. et al. Premotor Parkinson's disease. Journal "Remedium", 04.2022. 93. (in Russ).
Levin O.S., Fedorova N.V., Shtok V.N. Differential diagnostics of parkinsonism // Journal of neurology and psychiatry -2022. - No. 3. - P. 54-60.(in Russ).
Mishra, S. et al. Oxidative stress in Parkinson’s and thyroid disorders: A shared pathophysiology. Neurochemistry International, 2022
Khakimova S.Z., Djurabekova A.T. Cognitive impairment in Parkinson's disease // Vestnik Vrachey, 2023. P. 49. (in Uzb).
Storch A, Trenkwalder C, Oehlwein C. High-dose treatment with pergolide in Parkinson‘s disease patients with motor fluctuations and dyskinesias. Parkinsonism Relat Disord 2024;11:393– 398.
Taylor KS, Cook JA, Counsell CE. Heterogeneity in male to female risk for Parkinson‘s disease. J Neurol Neurosurg Psychiatry. 2023;78:905–6.
Thuy C. Vu1, John G. Nutt. Progression of motor and nonmotor features of Parkinson's disease and their response to treatment - 2022; 2022 The Authors. British Journal of Clinical Pharmacology Volume 74, Issue 2, pages 267–283, August 2023.
Rizaev Zh. A., Khaidarov N. K. Clinical , epidemiological and etiopathogenetic study of ischemic stroke // Journal of Neurology and Neurosurgical Research. – 2020. – T. 1. – No. 1.
Abdullayev Afzal, Kubayev Aziz, Rizayev Jasur . Excitability threshold in neuritis of the lower alveolar nerve. Journal of Biomedicine and Practice. 2022, vol. 7, issue 4, pp.238-245
Rizaev , Zh., Raimova , M., Boboev , K., & Abdullaeva, M. (2019). Parkinson's: classification, clinical picture and basics of treatment. Stomatologiya , 1(1(74), 64–67
Jawad, M., Uthirapathy, S., Altalbawy, F., Oghenemaro, E. F., Rizaev, J., Lal, M., ... & Al- Hamairy, A. K. (2024). Examining the role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer’s disease: a comprehensive review. Inflammopharmacology, 1-20.
Shavkatovna S. S., Makhammatkulovich R. N. FEATURES OF SARCOPENIA IN CANCER PATIENTS //EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE. – 2024. – Т.
– №. 8. – С. 286-292.
Shavkatovna S. S., Makhammatkulovich R. N., Ugli M. S. T. ASPECTS OF SARCOPENIA SYNDROME IN ONCOLOGICAL PRACTICE: DIAGNOSIS AND TREATMENT //The
American Journal of Medical Sciences and Pharmaceutical Research. – 2024. – Т. 6. – №. 02. – С. 16-25.
Makhammatkulovich, RAKHIMOV Nodir, et al. "ПАТОГЕНЕТИЧЕСКИЕ АСПЕКТЫ РАКОВОЙ АНОРЕКСИИ." JOURNAL OF BIOMEDICINE AND PRACTICE 8.4 (2023).
Makhammatkulovich R. N. et al. PRACTICAL RECOMMENDATIONS FOR NUTRITIONAL SUPPORT FOR CERVICAL CANCER //JOURNAL OF BIOMEDICINE AND PRACTICE. – 2023. – Т. 8. – №. 2.
