BOLALARDA O'TKIR PYELONEFRITDA TUBULOINTERSTITSIAL ZARARLANISHLARNI ERTA TASHXIS QILISHNING INNOVATSION USULLARI
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: Acute cholecystitis, navigational surgery, surgical and anesthetic risk, percutaneous transhepatic microcholecystostomy, endoscopic papilosphincterotomy##article.abstract##
COVID-19 pandemiyasi bolalarda yuqumli va yallig'lanishli buyrak kasalliklarining ilgari tan olinmagan klinik xususiyatlarini aniqladi. Maqsad: COVID-19 dan keyin o'tkir pielonefritli bolalarda klinik va laboratoriya diagnostikasida tubuloglomerulyar anomaliyalar biomarkerlarining (γ-GT, β2M, NGAL, KIM-1) ahamiyatini aniqlash. Usullar. Tadqiqotga klinik va laboratoriya tomonidan tasdiqlangan o'tkir pielonefritli 100 bola kiritilgan. Nazorat guruhi yoshi va jinsi bo'yicha mos keladigan 25 nafar sog'lom boladan iborat edi. Natijalar. Tadqiqot natijalari nazorat guruhiga nisbatan siydikdagi γ-GT, KIM-1, NGAL va β₂-mikroglobulin konsentratsiyasining statistik jihatdan sezilarli darajada oshganligini ko'rsatdi. Birinchi guruhdagi bemorlarda γ-GT darajasi nazorat guruhiga qaraganda 4,57 baravar, KIM-1 darajasi 3,77 baravar, NGAL darajasi 25,96 baravar va β₂M darajasi 7,64 baravar yuqori bo'lgan. Xulosa. Ushbu parametrlarning konsentratsiyasini aniqlash bizga tubulointerstisial shikastlanishning dastlabki belgilarini aniqlash, buyrak naychalari apparatida patologik jarayonning faolligini baholash va surunkali pielonefrit uchun xavf guruhlarini aniqlash imkonini beradi.
Библиографические ссылки
Akhmedzhanova N.I., Akhmedzhanov I.A., Ismailova Z.A., Gapparova G.N. Evaluation of the functional state of the kidneys in renal complications in children during the COVID-19 pandemic: an observational cohort retrospective clinical study. Kuban Scientific Medical Bulletin.2023;30(3):25-33. https://doi.org/10.25207/1608-6228-2023-30-3-25-33 , (in Russ).
Axmedjanova NI, Axmedjanov IA, Ismailova ZA, Gapparova GN. Evaluation of Kidney Functioning in Children with Renal Complications During COVID-19 Pandemic: A Retrospective Observational Cohort Clinical Study. Kuban Scientific Medical Bulletin. 2023;30(3):25-33, https://doi.org/10.25207/1608-6228-2023-30-3-25-33
Akhmedzhanova N.I., Akhmedzhanov I.A., Ismailova Z.A., Gapparova G.N. Clinical and laboratory assessment of renal complications in children during the COVID-19 pandemic. Doktor axborotnomasi. 2023;2(110):13-16. https://doi.org/10.38095/2181-466X-20231102-13-16, (in Russ).
Akhmedzhanova NI, Akhmedzhanov IA, Ismailova ZA, Gapparova GN. Clinical and laboratory evaluation of renal complications in children during the COVID-19 pandemic. Doktor axborotnomasi. 2023;2(110):13-16 (In Russ.). https://doi.org/10.38095/2181-466X-20231102-13-16
Bogdanova EO, Galkina OV, Zubina IM, Dobronravov VA. Urine proteins and fibroplastic changes in kidney compartments in immune glomerulopathies. Nephrology. 2017; 21 (6): 54-59. DOI:10.24884/1561-6274-2017- 21-6-54-59, (in Russ).
Trailin AV, Pletn MV, Nikonenko AS, et al. Diagnostic value of beta-2-microglobulin, enzymes, serum and urine interleukins in chronic renal allograft dysfunction // Clinical laboratory diagnostics. 2015;60(11):31–37, (in Russ).
Shamkhalova M.Sh., Mokrysheva N.G., Shestakova M.V. COVID-19 and kidneys. 2020;23(3):235-241. https://doi.org/10.14341/DM12506 (in Russ).
Alvarado А., Franceschi G., Resplandor E., Sumba J., // Orta N. COVID-19 associated with onset nephrotic Syndrome in a pediatric patient: considinse or related conditions? Pediatr Nephrol. 2021; 36(1):205–207. https://doi.org/10.1007/s00467-020-04724-y.
Abbasi A. Discriminatory Precision of Neutrophil Gelatinase-Associated Lipocalin in Detection of Urinary Tract Infection in Children: a Systematic Review and Meta-Analysis [Теxt] / A. Abbasi, F. Nabizadeh, M. Gardeh [et. al] // Arch Acad Emerg Med. – 2020. - V.8(1). – Р. 56.
Gabarre P., Dumas G., Dupont T., Darmon M., Azoulay E., Zafrani L. (2020). Acute kidney injury in critically ill patients with COVID-19. Intensive Care Med, 46, 1339–1348. https://doi.org/10.1007/s00134-020-06153-9
Hee Sun Baek, Min Hyun Cho. // Kidney complications associated with COVID-19 infection and vaccination in children and adolescents: a brief review// Clin.Exp. Pediatr Vol.66/№ 10, С. 424–431, 2023 https: doi. org. 10.3345 /cep. 2023. 00738.
Health RCoPaC. // Guidance: paediatric multisystem inflammatory syndrome temporally associated with COVID-19(PIMS). 2020.
Rizaev JA, Shamsiev JA, Zayniev SS Ways to Optimize Patient Outcomes and Improve the Quality of Medical Care in Surgically Correctable Congenital Malformations in Samarkand //European Journal of Research Development and Sustainability. – 2021. – T. 2. – No. 3. – pp. 45-48.
Alimjanovich, R. J. "MINIMALLY INVASIVE METHODS OF TREATMENT OF UROLITHIASIS IN CHILDREN. REVIEW OF THE CURRENT STATUS OF THE ISSUES." JOURNAL OF BIOMEDICINE AND PRACTICE 8.2 (2023).
