ANGIOPATIYA BILAN ASORATLANGAN 2-TIPI QANDLI DIABETDA GPX4 GENINDAGI C718T (RS713041) POLIMORFIZMINING AHAMIYATI
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GPX4 geni, C718T (RS713041) polimorfizmi, diabetik angiopatiya, oksidlovchi tizim, antioksidant tizim, qon-tomir shikastlanishi##article.abstract##
GPX4 geni (19p13.3 da joylashgan) 3' mintaqada (3'UTR) joylashgan, funktsional jihatdan C718T (rs713041) polimorfizmi qandli diabet kasalligida juda ahamiyatli. Ushbu tartibga soluvchi mintaqadagi mutatsiyalar xabarchi RNK (mRNK) barqarorligiga, tarjima samaradorligiga va oxir-oqibat hujayradagi faol ferment konsentratsiyasiga ta'sir qilishi ma'lum. Sitozinni (C) timin (T) o'rniga almashtirish GPX4 ferment faolligining pasayishi bilan bog'liq. Ushbu maqolada qandli diabetda angiopatiya bilan asoratlangan bemorlarda ushbu genning muhim jihatlari keltirilgan.
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