BIRIKTIRUVCHI TO’QIMA DIFFERENTSIALLASHMAGAN DISPLAZIYASI BOR BEMORLARDA TO’QIMA REMODELLASHTIRISH HOLATINI BAHOLASН
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Biriktiruvchi to'qima differentsiyalanmagan displaziyasi, metalloproteinazlar, metalloproteinazalarning to'qima ingibitorlari, magniy ionlari (Mg 2)##article.abstract##
Biriktiruvchi to'qima differentsiyalanmagan displaziyasi (BTDD) - turli xil klinik ko'rinishlar bilan ajralib turadigan har xil sindromlar va fenotiplarni o'z ichiga oladi. Ushbu ishning maqsadi 2.9 – turdagi matriksli metalloproteinazalarning (MMP-2,-9) ekspressiyasi, matriksli metalloproteinazalarning to'qima ingibitorlari (TIMP) va ularning magniy ionlari (Mg + 2) bilan o'zaro bog'liqligini, BTDD bemorlarning qondagi glikozaminoglikan va glyukuronidaza faolligini aniqlash uchun taqqoslama tekshiruvni o’tkazish. 15 yoshdan 25 yoshgacha (19,9 ± 1,42) bo’lgan 208 ta bemor tekshiruvdan o'tkazildi. Klinik belgilar va rivojlangan asoratlarga qarab, bemorlar 2 guruhga bo'lingan, 1-guruh - 97 BTDD ning tashqi fenotiplar (fenlari) belgilari bo'lgan bemorlar, 2-guruhi - ayrim asoratlari bilan tashqi va ichki fenlarning belgilariga ega bo'lgan 111 ta bemor. Tadqiqotlar shuni ko'rsatdiki, BTDD bilan kasallangan bemorlarning qonida MMP-2 va MMP-9 ning ko'payishi va TIMP-1ning pasayishi qayd etilgan. Kasallikning avj olib borishi bilan MMP-2 va MMP-9 ekspressiyasi kuchayadi va TIMP-1 nazorat ma'lumotlariga nisbatan kamayadi. Shu bilan birga, bemorlarda Mg + 2 ionlarining qonida pasayish kuzatiladi. Shunday qilib, BTDD bilan og'rigan bemorlarda MMP-2 va MMP-9, shuningdek TIMP-1 ekspressiyasidagi o'zgarishlarning dinamikasi patologik jarayonning rivojlanishini va kasallikning prognozini baholash uchun xizmat qilishi mumkin.
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