NOINVAZIV MUSHAK SARATONIDA QOVUQ ICHI KIMYOTERAPIYA BALAN DAVOLASH USULI EFFECTIVLIGI
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siydik pufagi saratoni, intravezikal kimyoterapiya, transuretral rezeksiya##article.abstract##
Quviq saratoni-dunyodagi siydik traktining barcha o’smalari orasida ikkinchi eng ko'p uchraydigan saraton. Eng ko’p uchraydigan gistologil turi urotelial saraton bo’lib barcha qovuq o'smalarini 90-95% gacha hosil qiladi. Ko'p hollarda, qovuq yuzaki saraton davolash transuretral rezektsiya (TUR) bilan boshlanadi. Bemorlarning xarakteristikalariga va kuzatuv davomiyligiga qarab, yuzaki o'smalarning 80% qaytalanadi va 2-50% mushak-invaziv o'simtaga aylanadi. Ko’p o’smani qayta takrorlanishi va oldini olish uchun yuzaki qovuq saratonida intravezikal kimyoterapiya o’tkaziladi. O'simta jarrohlik usulida olib tashlash bilan bir qatorda, uni qaytalanishini oldini olishga qaratilgan boshqa davolash usulini amalga oshirilishi lozim. Shu maqsadda intravezikal kimyoterapiya yoki immunoterapiya qo'llaniladi. Yuzaki qovuq saratonida eng samarali dorilar Adriamisin (doxorubitsine), pharmarubitsine (epirubisin)lardir. Shunday qilib, qovuq ichi kimyoterapiyasi yuzaki QS bo'lgan bemorlarni davolashda keng qo'llaniladi.
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