MDR GEN POLIMORFIZMLARI - SARATON KASALLIGIDA KIMYOTERAPIYA CHIDAMLILIGI MARKERLARI
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DNA, polimorfizm, MDR1, C3435T, SBS, NHL, Saraton##article.abstract##
Maqsad: kimyoterapiya individual rejimini bashorat qilish polimorfik marker C3435T MDR1 gen tomonidan saraton bemorlarning shaxsiy genotip dori qarshilik aniqlash.
Material va Metodlar: tadqiqotlarni amalga oshirish paytida, Sut bezlari saratoni (SBS) (80 nafar bemor) va Nexodjkin limfoma (NHL) (75 bemor) periferik qonli leykotsitlardan olingan DNK namunalari ishlatilgan.
Natijalar: MDR1 genining C3435T polimorf markeridagi bemorlarda genetik xususiyatlarni aniqlash farmakologik javobning xususiyatini taxmin qilish imkonini beradi, bu esa dori vositalarining samaradorligi va xavfsizligini oshirish imkonini beradi - doza, qo'llanilishning ko'pligi, administratsiya yo'li, dori vositalarini almashtirish va turli xil onkologik kasalliklar uchun farmakoterapiyani individuallashtirishning haqiqiy imkoniyati. Ko'krak bezi saratoni va Nexodjkin limfoma bilan kasallangan sog'lom donorlar va onkologik bemorlar orasida genotiplarning paydo bo'lish chastotasini aniqlash o'tkazildi
Xulosa: Ko'krak bezi saratoni va Hodgkin bo'lmagan limfoma uchun TT homozigot genotipining chastotasi CC va CT genotiplarining paydo bo'lishidan yuqori ekanligini ko'rsatadi.
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