COVID-19 BEMORLARGA ERTA REABILITASIYA DAVRIDA JIGARNING FUNKSIONAL O'ZGARISHLARI
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koronavirus infeksiyasi, SARS-CoV2, COVID-19, jigar zararlanishi##article.abstract##
Tadqiqot maqsadi: COVID-19 ning erta reabilitatsiya davridagi bemorlarda jigarning strukturaviy va funktsional holatini baholash.
Materiallar va tadqiqot usullari. 18-60 yoshli COVID-19 bilan kasallangan 243 nafar bemor kuzatuv ostida edi. Tadqiqotga mezonlari: COVID-19 tadqiqotiga kirishdan kamida 10 kun oldin o'tkazilgan; tadqiqotga kiritish vaqtida PCR-salbiy COVID-19, salbiy PCR va gepatit viruslari replikatsiyasining markerlari. Nazorat guruhi (NG) 20 nafar sog'lom kishilar.
Tadqiqot natijalari. Tadqiqotga kiritilgan COVID-19 bilan kasallangan bemorlarda qon fermentlarining faolligi NG bilan solishtirganda sezilarli darajada oshdi: ALT KGdagi o'rtacha qiymatlardan deyarli 10 baravar, AST = deyarli 3 baravar, LDG 3 baravar, GGT dan oshdi. va ALP - deyarli bir yarim barobar. NGda bilirubin darajasi NGda qayd etilganidan sezilarli darajada yuqori edi (p<0,001). Bemorlarning periferik qonida albumin kontsentratsiyasi pasaygan (p<0,001, NG dan sezilarli farq). KG ga nisbatan sezilarli darajada yuqori (p<0,01). Ko'pgina bemorlarda elastografiya aniqlanganda, F0 (52,67%), kamroq - F1 (21,16%), F2 (14,81%) va F3 (5,35%) qayd etilgan.
Xulosa. Erta reabilitatsiya davrida COVID-19 dan o'tgan bemorlarda gepatobiliar tizimda sitolitik, xolestatik sindrom, jigarning oqsil sintez qilish funktsiyasining pasayishi, shuningdek, o'sish bilan tavsiflangan tarkibiy va funktsional o'zgarishlar qayd etilgan. jigar kattaligi, darvoza va taloq venalarining diametrlari va jigar parenximasining qattiqligining oshishi.
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