ODAM PAPILLOMA VIRUSI ASSOSTIYALASHGAN OGIZ-HALQUM YASSI HUJAYRALI KARSINOMASIDA PD-L1 VA P53 OQSILLARINI EKSPRESSIYASINING AHAMIYATI
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Ogiz-halqum yassi hujayrali karsinomasi, odam papilloma virusi, immunogistokimyo, molekulyar marker, oqsil ekspressiyasi, p16INK4a, PD-L1, p53.##article.abstract##
Yuqori xavfdagi odam papilloma virusi (OPV) ogiz-halqum yassi hujayrali karsinomasini (OHYHK) keltirib chiqarib, asosan bodomsimon bezlarning va til asosining limfoid to'qimalaridan kelib chiqadigan o'smalarning taxminan 70% da aniqlanadi. Tadqiqotga 2015-2020-yillarda Respublika ixtisoslashtirilgan onkologiya va radiologiya ilmiy-amaliy tibbiyot markazi va uning Toshkent shahar filialida davolangan T1-4N0-3M0 (AJCC, 7-nashr) OHYHK bilan kasallangan 76 nafar bemor ishtirok etdi. 30ta tanlangan bemorlar gistologik preparatlari uchta molekulyar markerlarning P16INK4a, PD-L1 va p53 ekspressiyasi IGK yordamida baholandi. p16INK4a ning yuqori ekspressiyasi 46% (6/13) da ijobiy PD-L1 reaktsiyasi bilan birga kuzatildi va p53 mutant turining ijobiy ifodasi kuzatilmadi. Shuni ta'kidlash kerakki, p53 tabiy turi p16INK4a ning haddan tashqari ifodalanishi bilan birgalikda faqat 1 holatda (3%) aniqlandi. OHYHK molekulyar profilini aniqlash uning biologik xususiyatlarini yaxshiroq tushunishga yordam beradi, bundan tashqari, u kasalliklarning oldini olish va samarali davolashda muhim rol o'ynaydi.
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