CYP2C19 GENINING G681A ALLEL POLIMORFIZMINING ERKAK TUG'ILISHINING BUZILISHI GENEZISIDAGI AHAMIYATI
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erkaklar bepushtligi, CYP2C19 genining G681A polimorfizmi, allel, genotip##article.abstract##
CYP2C19 genining G681A polimorfizmining erkaklar bepushtligining shakllanishidagi roli tahlil qilindi. Tadqiqot erkaklar bepushtligining turli klinik shakllariga ega bo'lgan 140 nafar bemor va 155 shartli sog'lom fertil erkaklar namunasi bo'yicha o'tkazildi. Ushbu lokusning jinsiy gormonlar, ayniqsa androgenlar sintezini tartibga solishda ishtirok etishiga qaramay, ushbu genning noqulay variantini tashish erkaklarning fertilligining buzilishiga mustaqil fenotipik ta'sir ko'rsatmaydi, bu bizga ushbu genning jinsiy gormonlar, ayniqsa, androgenlar sintezini tartibga solishda ishtirok etmaydi, degan xulosaga kelishimizga imkon beradi. Erkaklarning tug'ilishining buzilishi geneziyasida mustaqil rol o'ynaydi.
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