PGC-1A (G / A) GENINING OSHQOZON VA O’N IKKI BARMOQLI ICHAK YARASI DIAGNOSTIKASIDAGI AHAMIYATI
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molekulyar genetika, oshqozon yarasi va o'n ikki barmoqli ichak yarasi##article.abstract##
Tadqiqot maqsadi: Oshqozon yarasi va o'n ikki barmoqli ichak yarasining patogenezida va kechishida PGC-1A(G/A) yallig'lanish regulyatori gen-determinantining rolini tahlil qilish.
Materiallar va tadqiqot usullari: OYaK va O’BIYK bilan kasallangan 100 nafar bemor tekshirildi, ulardan PCR yordamida PGC-1A(G/A) polimorfik variantlari tahlil qilindi, va shulardan asoratli (n
= 49) hamda asoratsiz (n = 51) guruhlar aniqlandi.
Natijalar: PGC-1A(G/A) oshqozon yarasi va o’n ikki barmoqli ichak yarasi rivojlanishining markeri hisoblanadi.
Xulosa: Oshqozon yarasi va o'n ikki barmoqli ichak yarasi bo'lgan bemorlarda PGC-1A(G/A) gen- sitokinlarining genotipik variantlarining chastotalarini aniqlash, yangi diagnostika mezonlari va boshqarish taktikasini ishlab chiqish va amalga oshirishga yordam beradi.
Библиографические ссылки
Burada F. Angelescu C., Ioana M., Mitrut P., Moraru E., Riza A. et al. IL-10-1082 A/G POLYMORPHISM AND RISK OF THE GASTRIC CANCER. Annals of RSCB. 2010;15(1):93-97. Vol.13 No.2 Spring 2018 IRANIAN JOURNAL OF PATHOLOGY.
Cheng H.H., Chang C.S., Wang H.J., Wang W.C. Interleukin-1beta and -10 polymorphisms influence erosive reflux esophagitis and gastritis in Taiwanese patients J Gastroenterol Hepatol, 25 (2010), pp. 1443-1451.
Kang J.M., Kim N., Lee D.H., Park J.H., Lee M.K., Kim J.S. et al. The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea J Clin Gastroenterol, 43 (2009), pp. . 420-428.
Kavitt RT, Lipowska AM, Anyane-Yeboa A, Gralnek IM. Diagnosis and Treatment of Peptic Ulcer Disease. Am J Med. 2019 Apr;132(4):447-456. doi: 10.1016/j.amjmed.2018.12.009. Epub 2019 Jan 3. PMID: 30611829.
Lehours P, Ferrero RL. Review: Helicobacter: Inflammation, immunology, and vaccines. Helicobacter. 2019 Sep;24 Suppl 1:e12644. doi: 10.1111/hel.12644. PMID: 31486236.
Martínez-Campos, C., Torres-Poveda, K., Camorlinga-Ponce, M. et al. Polymorphisms in IL- 10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population. BMC Cancer 19, 453 (2019). https://doi.org/10.1186/s12885-019-5627-z
Narayanan M, Reddy KM, Marsicano E. Peptic Ulcer Disease and Helicobacter pylori infection. Mo Med. 2018 May-Jun;115(3):219-224. PMID: 30228726; PMCID: PMC6140150.
Rad R., Dossumbekova A., Neu B., Lang R., Bauer S., Saur D. et al. Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection. Gut. 2004;53(8):1082-9. https://doi.org/10.1136/gut.2003.029736 PMID:15247172 PMCID:PMC1774164.
Rezaeishahmirzadi M., Motamedi Rad N., Kalantar M., Ayatollahi H., Shakeri S., Sheikhi M., Shekari M. The Association of Gastritis and Peptic Ulcer With Polymorphisms in the Inflammatory-related Genes IL-4 and in Iranian Population Iran J Pathol.2018; 13(2): 229-236.
Seno H., Satoh K., Tsuji S., Shiratsuchi T., Harada Y., Hamajima N. et al. Novel interleukin‐4 and interleukin‐1 receptor antagonist gene variations associated with non‐cardia gastric cancer in Japan: comprehensive analysis of 207 polymorphisms of 11 cytokine genes. J Gastroenterol Hepatol. 2007;22(5):729-37. https://doi.org/10.1111/j.1440-1746.2007.04934.x PMID:17444864.
Sverdén E, Agréus L, Dunn JM, Lagergren J. Peptic ulcer disease. BMJ. 2019 Oct 2;367:l5495. doi: 10.1136/bmj.l5495. PMID: 31578179.
Tourani M, Habibzadeh M, Karkhah A, Shokri-Shirvani J, Barari L, Nouri HR. Association of TNF-α but not IL-1β levels with the presence of Helicobacter pylori infection increased the risk of peptic ulcer development. Cytokine. 2018 Oct;110:232-236. doi: 10.1016/j.cyto.2018.01.003. Epub 2018 Feb 16. PMID: 29456060.
Xue H., Lin B., An J., Zhu Y., Huang G. Interleukin-10-819 promoter polymorphism in association with gastric cancer risk. BMC Cancer. 2012;12(1):102.https://doi.org/10.1186/1471-2407-12-102 MID:22436502 PMCID:PMC 3384469.
Zambon C.F., Basso D., Navaglia F., Belluco C., Falda A., Fogar P. et al. Pro- and anti- inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome Cytokine, 29 (2005), pp. 141-152.
Бабаев С. и др. Assessment of the state of immunity in patients with tumors //in Library. – 2021. – Т. 21. – №. 2. – С. 218-225.
Ziyadullaev S. et al. Cytogenetic and immunological alterations of recurrent bladder cancer //European Journal of Molecular and Clinical Medicine. – 2020. – Т. 7. – №. 2. – С. 1877-1883.
Yusupov Mashrab, Rizaev Zhasur, Ziyadullaev Shuxrat. The value of cytokines in children with escherichiosis. Journal of Biomedicine and Practice. 2022, vol. 7, issue 4, pp.58-63
